The role of neuronal compartmentalization in generating specific behavioural responses in C. elegans

Projektinformationen

KEBUSCH

ID Finanzhilfevereinbarung: 518504

Startdatum 1 Dezember 2005

Enddatum 30 November 2007

Finanziert unter

• Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Gesamtkosten € 0,00

EU-Beitrag € 159 046,00

Koordiniert durch

MEDICAL RESEARCH COUNCIL
United Kingdom

Ziel

A fundamental question in neurobiology is how specific behaviours are controlled at the level of molecules, cells, and neuralcircuits. In this proposal I aim to investigate how different synapses within the same neuron are specialized, how thisspecializati on contributes to, information processing in the neuron and, ultimately, to specific behavioural responses. Toinvestigate this problem I will study feeding behaviour in the nematode C. elegans. Different wild strains of C. elegans exhibitdifferent feeding strategies, which can be causally linked to the specific action of receptors, sensory neurons, andinterneurons. I will combine genome-wide RNAi screening with forward genetic approaches to identify new molecules thatcontrol how C. elegans respond to food. The function of these genes will be tested using 1. Behavioural assays, 2. Newlydeveloped labels for different post-synaptic elements in the same interneuron, and 3. Genetically encoded indicators of neuralactivity. Ultimately, I hope to understand how inf ormation received at distinct post-synaptic elements from different pre-synaptic partners sculpts neuronal output and behavioural response.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › neurobiology
• natural sciences › chemical sciences › inorganic chemistry › alkaline earth metals
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• agricultural sciences › agriculture, forestry, and fisheries › agriculture › industrial crops › fodder
• natural sciences › computer and information sciences › data science › data processing

Schlüsselbegriffe

• Feeding behaviour
• RNAi genome-wide screening
• neural circuits
• neural imaging
• neuronal compartmentalization

Programm/Programme

• FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Thema/Themen

• MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF)

Aufforderung zur Vorschlagseinreichung

FP6-2004-MOBILITY-5
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

EIF - Marie Curie actions-Intra-European Fellowships

Koordinator

MEDICAL RESEARCH COUNCIL

• EU-Beitrag: Keine Daten
• Adresse: 20 Park Crescent ; CAMBRIDGE ; Vereinigtes Königreich
• Gesamtkosten: Keine Daten