Objective
The DLK1-GTL2 domain is a recently discovered,evolutionary served,H 1 Mb cluster of imprinted genes mapping to 14q32 in man,distal 12 in the mouse and distal 18q in sheep.It tains at least four protein encoding genes expressed from the paternal allele (DLK1,RTL1,DIO3 and BEGAIN),as well as a series of non coding RNA genes expressed from the maternal allele (e.g. GTL2, MEG8, MIRG).It was recently demonstrated that the DLK1-GTL2 domain tains multiple small non coding RNA genes.More specifically,it includes (i) a pair of miRNA genes (miR-127 and miR-136) antisense to RTL1, (ii) a clusters of H C/D snoRNA genes thought to be processed from the introns of the non coding MEG8 gene,and (iii) a cluster of H 40 miRNA genes thought to be processed from a large precursor transcript referred to as MIRG. Elucidating the biological function and mode of action of the miRNA genes in the DLK1-GTL2 domain is the topic of this proposal.More precisely,the objectives of the Callimir proposal are:(i) to study the role of the miR-127 and miR-136 genes in development and in regulating the expression of the RTL1 gene and (ii) to study the role of the MIRG cluster of miRNA genes in development and in mediating the trans effect underlying polar overdominance.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences genetics genomes
- natural sciences computer and information sciences internet world wide web
- natural sciences biological sciences molecular biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-LIFESCIHEALTH-I
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LIÈGE
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.