Objective
Bacterial protein secretion is a fundamental biological process of the utmost relevance to human health. On one hand, this process can be exploited successfully to the benefit of human health through the biotechnological production of biopharmaceuticals. On the other hand, secreted bacterial toxins and virulence factors represent a major threat to human health. The Twin-arginine translocation (Tat) machinery represents a recently discovered, but widely conserved system for bacterial protein secretion. This multi-subunit nanomachine can transport fully folded proteins and thus has a huge potential for biopharmaceutical production in bacterial species that are already used for this purpose, including Bacillus, Escherichia coli and Streptomyces. It has furthermore been demonstrated that critical virulence factors are secreted via Tat in important pathogens, such as Pseudomonas aeruginosa and E. coli O157.
The Tat machine programme aims at the multidisciplinary functional genomic characterisation of the Tat nanomachine for both biotechnological and biomedical purposes. We will: (A) eliminate the current bottlenecks in the Tat nanomachine that limit biopharmaceutical production in Bacillus, E. coli and Streptomyces; and (B) characterise the structure and function of Tat nanomachines from a few selected Gram-positive and Gram-negative bacteria, including major pathogens. To reach these goals, the full potential of bioinformatics, comparative and structural genomics, and proteomics will be exploited. The Tat machine partnership has a proven track record in the application of these cutting-edge technologies and includes Europe's leading groups in the field of Tat machinery analysis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- natural sciences biological sciences zoology mammalogy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-LIFESCIHEALTH-I
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
GRONINGEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.