Objective
The dynamics of biomembrane lipid organisation and its physiological role is a rapidly developing interdisciplinary field. Membrane dynamics is largely controlled by lipid transporters also known as flippases, which play a pivotal role in cell homeostasis. Putative flippases belong to various subfamilies of the P-type ATPases and ATP-binding cassette (ABC) transporters. These proteins are involved in regulating lipid asymmetry, cellular signalling, in the budding of transport vesicles and protein synthesis. Dysfunction of flippases causes severe diseases like cholestasis, atherosclerosis, visual impairment, what emphasises their crucial physiological function. Although these proteins have been connected with the translocation of various classes of membrane lipids across cellular membranes, biochemical and genetic proof of their function and the key features of their activity remain to be elucidated. The network teaming 12 groups is aimed at undertaking an interdisciplinary effort to reveal the molecular identity and cellular localisation of flippases, their three-dimensional structure, substrate specificity, the molecular mechanism, energetics and regulation of their functioning, as well as unraveling the consequences of their action for cell and body physiology. Biophysical approaches will be used to address lipid transport energetics and its role in membrane budding, fission and fusion. The teams have complementary expertise at the highest standard in all required techniques of molecular and cell biology, biochemistry, proteomics, structural biology including X-ray crystal analysis and cryoelectron microscopy, and theoretical and experimental biophysics. In addition to providing novel applicative insights into flippase-related diseases, this project will identify potential targets for designed drug development in pharmaceutics, and will offer new biotechnological tools to use cellular model systems in production of e.g. lipophilic drugs and probiotic food.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences cell biology
- natural sciences physical sciences optics microscopy
- natural sciences biological sciences biochemistry biomolecules lipids
- natural sciences biological sciences molecular biology structural biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-1
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BERLIN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.