Skip to main content

Human cystic Echinococcosis ReseArch in CentraL and Eastern Societies

Objective

Human cystic echinococcosis (CE), one of the most widespread helminthic zoonoses, is a chronic disease caused by infection with the larval stage of the tapeworm Echinococcus granulosus. This disease is highly endemic in some southern (Spain and Italy), eastern (Bulgaria and Romania) European countries and associated (Turkey) countries, where it still represents a major health and economic problem. In endemic areas the annual incidence of CE ranges from 1 to 200 per 100,000 inhabitants and 2-3 million cases are globally estimated. Case series and small clinical trials show a mortality rate of 2-4% for CE, but this increases markedly with substandard treatment and care. The diagnosis of human CE is mainly based on imaging techniques and serological confirmation. Clinical decision making is difficult and the natural history of the cyst is still poorly known. CE is chronic, complex and still neglected. For these reasons the main objectives of HERACLES are:

• Identify by ultrasound screening the population affected by CE in endemic rural areas of CEE countries;
• Create CEE national registries for surveillance of CE;
• Establish a representative bio-bank of genetic Egc isolates and blood/serum/plasma samples;
• Validate new molecular-based POC-LOC kits for immunological surveillance, diagnosis and follow-up;
• Identify factor/s associated with CE response to therapy or lack thereof through investigation of host-parasite interplay (parasite virulence vs human immunity);
• Increase drug bioavailability in an in vivo model, decreasing the length of antiparasitic (ABZ based) treatment of CE and synthesize a new enantiomeric drug based on ABZ.

The project stakeholders, especially the rural populations in which CE is endemic, as well as SMEs, will be engaged as an integral part of the project. Special events to increase general awareness of CE and training activities for local health care providers will be organized.

Field of science

  • /medical and health sciences/health sciences/epidemiology/zoonosis

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

ISTITUTO SUPERIORE DI SANITA
Address
Viale Regina Elena 299
00161 Roma
Italy
Activity type
Research Organisations
EU contribution
€ 752 208
Administrative Contact
Rosa Martoccia (Dr.)

Participants (9)

UNIVERSITA DEGLI STUDI DI PAVIA
Italy
EU contribution
€ 421 230
Address
Strada Nuova 65
27100 Pavia
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sofia Baggini (Dr.)
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 483 092
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
María ángeles López Vázquez (Ms.)
SPITATUL CLINIC COLENTINA BUCURESTI
Romania
EU contribution
€ 335 000
Address
Soseaua Stefan Cel Mare 19-21
020125 Bucuresti
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Maria Dinescu (Dr.)
HACETTEPE UNIVERSITESI
Turkey
EU contribution
€ 350 000
Address
Hacettepe Universitesi Beytepe Kampusu Rektorluk Binasi
06800 Cankaya Ankara
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Serpil Sevtap Benli (Dr.)
"SPECIALIZED HOSPITAL FOR ACTIVE TREATMENT OF INFECTIOUS AND PARASITIC DISEASES ""PROF. I. KIROV'"
Bulgaria
EU contribution
€ 180 000
Address
Acad. Ivan Geshov Blvd 17
1606 Sofia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Kamenna Marinova Vutova (Prof.)
MINISTRY OF AGRICULTURE AND FORESTRY

Participation ended

Turkey
Address
Eskişehir Yolu 9. Km
06000 Ankara
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Alparslan Temucin (Dr.)
ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU
Italy
EU contribution
€ 125 000
Address
Via Fiorentina 151
53100 Siena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Cristiana Tozzi (Dr.)
VIRCELL SL
Spain
EU contribution
€ 119 970
Address
P.i Dos De Octubre Pza Dominguez Ortiz 1
18320 Santa Fe Granada
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Arantxa Cortés (Dr.)
TEKIRDAG NAMIK KEMAL UNIVERSITESI
Turkey
EU contribution
€ 95 000
Address
Namik Kemal University Campus
59030 Tekirdağ
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mustafa Durgut (Mr.)