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Personalised Prognostic Tools for Early Psychosis Management

Objectif

Affective and non-affective psychoses have a major negative impact on human society. They account for 6.3% of the global burden of disease and cost €207 billion per year in Europe alone, making them the most expensive brain-related disorders and even more expensive than cardiovascular diseases. This socioeconomic burden is largely caused by two core disease features: onset in adolescence and early adulthood and long-term disabling disease courses. Both factors lead to enduring social and vocational exclusion and contribute to 8-20 times higher suicide rates in affected patients.
Reliable and accessible prognostic tools will alleviate this burden by enabling individualised risk prediction, thus facilitating the targeted prevention of psychoses. Thus, we will first use routine brain imaging and complementary data to optimise our candidate biomarkers for the prediction and staging of psychoses and generate a prognostic system that generalises well across mental health services. Secondly, we will implement new multi-modal risk quantification tools to predict mental health-related disability in young help-seekers. The fusion of these tools with clinical knowledge will produce cybernetic prognostic services that accurately identify help-seekers at the highest risk of psychosis, poor functioning and suicide-related mortality.
During this project we will secure our intellectual property rights and transform into a European company to commercially exploit these prognostic services through internet-based telemedicine applications. This will provide psychosis risk profiling tools to diverse target groups in the healthcare markets, including care-givers, the pharmaceutical industry and research institutions. By disseminating objective risk quantification, these products will provide firm diagnostic grounds for preventive therapy, improving outcomes and reducing costs. Thus, they will offer a unique selling proposition to the mental health sectors in Europe and beyond.

Appel à propositions

FP7-HEALTH-2013-INNOVATION-1
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Coordinateur

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Adresse
Geschwister Scholl Platz 1
80539 Muenchen
Allemagne

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Nikolaos Koutsouleris (Dr.)
Contribution de l’UE
€ 840 628

Participants (17)

UNIVERSITAT BASEL
Suisse
Contribution de l’UE
€ 615 808
Adresse
Petersplatz 1
4051 Basel

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Stefan Borgwardt (Prof.)
KLINIKUM DER UNIVERSITAET ZU KOELN
Allemagne
Contribution de l’UE
€ 637 700
Adresse
Kerpener Strasse 62
50937 Koeln

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Petra Schreiner-Kaub (Mrs.)
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
Contribution de l’UE
€ 677 265
Adresse
Edgbaston
B15 2TT Birmingham

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
May Chung (Ms.)
TURUN YLIOPISTO
Finlande
Contribution de l’UE
€ 672 919
Adresse
Yliopistonmaki
20014 Turku

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Mari Riipinen (Dr.)
UNIVERSITA DEGLI STUDI DI UDINE
Italie
Contribution de l’UE
€ 338 151
Adresse
Via Palladio 8
33100 Udine

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Marina Dorligh
UNIVERSITY OF MELBOURNE
Australie
Adresse
Parkvilleoffice Of The Vice Chancellor
3010 Melbourne

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Melinda Heron (Ms.)
DYNAMIC EVOLUTION GMBH
Allemagne
Contribution de l’UE
€ 833 220
Adresse
Lichtenbergstrasse 8
85748 Garching

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Michael Jovicevic (Mr.)
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG

Participation terminée

Allemagne
Contribution de l’UE
€ 188 997
Adresse
Oskar Von Miller Ring 29
80333 Muenchen

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Birgit Fuchs (Ms.)
GENERAL ELECTRIC DEUTSCHLAND HOLDING GMBH
Allemagne
Contribution de l’UE
€ 545 444
Adresse
Bleichstrasse 64-66
60313 Frankfurt Am Main

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Manuela Abraham
GE HEALTHCARE GMBH - GEHC
Allemagne
Contribution de l’UE
€ 21 425
Adresse
Beethovenstrasse 239
42655 Solingen

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Timo Schirmer (Dr.)
UNIVERSITA DEGLI STUDI DI MILANO
Italie
Contribution de l’UE
€ 335 744
Adresse
Via Festa Del Perdono 7
20122 Milano

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Maria Antonia Giofrè (Dr.)
ARTTIC
France
Contribution de l’UE
€ 125 639
Adresse
39 Rue Des Mathurins
75008 Paris

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Martin Dietz (Dr.)
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Allemagne
Contribution de l’UE
€ 35 850
Adresse
Schlossplatz 2
48149 Muenster

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Katharina Steinberg (Dr.)
UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
Italie
Contribution de l’UE
€ 35 850
Adresse
Piazza Umberto I 1
70121 Bari

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Riccarda Lomuscio
HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Allemagne
Contribution de l’UE
€ 35 360
Adresse
Universitaetsstrasse 1
40225 Dusseldorf

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Eftimia Latrovali
UNIVERSITATSKLINIKUM BONN
Allemagne
Contribution de l’UE
€ 60 000
Adresse
Venusberg-campus 1
53127 Bonn

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Beate Becker (Mrs.)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Allemagne
Adresse
Hofgartenstrasse 8
80539 Munchen

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Type d’activité
Research Organisations
Contact administratif
Ralf Tatzel (Dr.)