Objetivo Diabetes is caused by insufficient or lack of insulin secretion by the specialized B cells of the pancreas and, if not treated adequately evolves into in complications which alter patients integrity and wellness. Treatment is based on lifetime drugs administration for blood glucose control or parenteral infusion of insulin to better control glucose levels and glycosylation of hemoglobin. Artificial pancreases are in development but still dependent by external energy sources and need permanent transcutaneous access to release the hormone. Pancreatic whole organ transplantation is a major intervention requiring selected recipient and matched cadaveric donor which keep numbers down. Islet of Langerhans transplantation is a non-invasive method for the treatment of type 1 diabetes but several questions remain and several issues have to be addressed in order to improve the method since islet engraftment is clearly suboptimal, as a result of pro-apoptotic and pro-inflammatory stimuli sustained during islet isolation and at the site of implantation, the long-term islet graft function drops to 15% with time, and the current systemic immunosuppressive regimen has several drawbacks in terms of side effects. Solution should be find to increase transplantation efficiency with an higher number of islet, eventually from animals, induce tolerance toward the graft, avoiding systemic, lifetime immunosuppression and, lowering a specific inflammatory reaction and enhancing graft micro vasculogenesis to improve islet nesting. NEXT provides a 360° solution to the pitfalls of current methodology for pancreatic islet transplantation: i) Nano technologies, to engineer donor cell surfaces in order to derange recognition and suppress their rejection; ii) Advanced tissue engineering methods, to assemble bio synthetic islet, enriched by chimeric microvasculature; iii) Innovative double immune-suppressive strategy by graft - bound immunosuppressive nano peptides and shielded by self- vasculature Ámbito científico natural sciencesbiological sciencesbiochemistrybiomoleculesmedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesmedical biotechnologytissue engineeringartificial pancreasmedical and health sciencesclinical medicinetransplantation Programa(s) FP7-HEALTH - Specific Programme "Cooperation": Health Tema(s) HEALTH.2013.1.3-2 - Innovative approaches to address adverse immune reactions to biomedical devices, implants and transplant tissues Convocatoria de propuestas FP7-HEALTH-2013-INNOVATION-1 Consulte otros proyectos de esta convocatoria Régimen de financiación CP-FP - Small or medium-scale focused research project Coordinador UNIVERSITY OF BRIGHTON Aportación de la UE € 670 581,20 Dirección LEWES ROAD MITHRAS HOUSE BN2 4AT Brighton Reino Unido Ver en el mapa Región South East (England) Surrey, East and West Sussex Brighton and Hove Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Matteo Santin (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (5) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo EXPLORA SRL Italia Aportación de la UE € 1 125 385,40 Dirección Via Giacomo Peroni 386 00131 Roma Ver en el mapa Región Centro (IT) Lazio Roma Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Federica Marotti (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos CELLON SA Luxemburgo Aportación de la UE € 450 875,00 Dirección RUE HEIERCHEN 16 ZAE ROBERT STEICHEN 4940 BASCHARAGE Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Richard Fry (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos UNIVERSITE DE GENEVE Suiza Aportación de la UE € 764 208,40 Dirección RUE DU GENERAL DUFOUR 24 1211 Geneve Ver en el mapa Región Schweiz/Suisse/Svizzera Région lémanique Genève Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Thierry Berney (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos AvantiCell Science Ltd Reino Unido Aportación de la UE € 875 023,40 Dirección GIBBSYARD BUILDING KA6 5HW Ayr Ver en el mapa Región Scotland Southern Scotland South Ayrshire Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Joanna Oliver (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos ISTITUTO MEDITERRANEO PER I TRAPIANTI E TERAPIE AD ALTA SPECIALIZZAZIONE SRL - ISMETT SRL Italia Aportación de la UE € 855 653,00 Dirección DISCESA DEI GIUDICI 4 90133 Palermo Ver en el mapa Región Isole Sicilia Palermo Tipo de actividad Other Contacto administrativo Fabrizio Campisi (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos