Cel Diabetes is caused by insufficient or lack of insulin secretion by the specialized B cells of the pancreas and, if not treated adequately evolves into in complications which alter patients integrity and wellness. Treatment is based on lifetime drugs administration for blood glucose control or parenteral infusion of insulin to better control glucose levels and glycosylation of hemoglobin. Artificial pancreases are in development but still dependent by external energy sources and need permanent transcutaneous access to release the hormone. Pancreatic whole organ transplantation is a major intervention requiring selected recipient and matched cadaveric donor which keep numbers down. Islet of Langerhans transplantation is a non-invasive method for the treatment of type 1 diabetes but several questions remain and several issues have to be addressed in order to improve the method since islet engraftment is clearly suboptimal, as a result of pro-apoptotic and pro-inflammatory stimuli sustained during islet isolation and at the site of implantation, the long-term islet graft function drops to 15% with time, and the current systemic immunosuppressive regimen has several drawbacks in terms of side effects. Solution should be find to increase transplantation efficiency with an higher number of islet, eventually from animals, induce tolerance toward the graft, avoiding systemic, lifetime immunosuppression and, lowering a specific inflammatory reaction and enhancing graft micro vasculogenesis to improve islet nesting. NEXT provides a 360° solution to the pitfalls of current methodology for pancreatic islet transplantation: i) Nano technologies, to engineer donor cell surfaces in order to derange recognition and suppress their rejection; ii) Advanced tissue engineering methods, to assemble bio synthetic islet, enriched by chimeric microvasculature; iii) Innovative double immune-suppressive strategy by graft - bound immunosuppressive nano peptides and shielded by self- vasculature Dziedzina nauki natural sciencesbiological sciencesbiochemistrybiomoleculesmedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesmedical biotechnologytissue engineeringartificial pancreasmedical and health sciencesclinical medicinetransplantation Program(-y) FP7-HEALTH - Specific Programme "Cooperation": Health Temat(-y) HEALTH.2013.1.3-2 - Innovative approaches to address adverse immune reactions to biomedical devices, implants and transplant tissues Zaproszenie do składania wniosków FP7-HEALTH-2013-INNOVATION-1 Zobacz inne projekty w ramach tego zaproszenia System finansowania CP-FP - Small or medium-scale focused research project Koordynator UNIVERSITY OF BRIGHTON Wkład UE € 670 581,20 Adres LEWES ROAD MITHRAS HOUSE BN2 4AT Brighton Zjednoczone Królestwo Zobacz na mapie Region South East (England) Surrey, East and West Sussex Brighton and Hove Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Matteo Santin (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (5) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko EXPLORA SRL Włochy Wkład UE € 1 125 385,40 Adres Via Giacomo Peroni 386 00131 Roma Zobacz na mapie Region Centro (IT) Lazio Roma Rodzaj działalności Private for-profit entities (excluding Higher or Secondary Education Establishments) Kontakt administracyjny Federica Marotti (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych CELLON SA Luksemburg Wkład UE € 450 875,00 Adres RUE HEIERCHEN 16 ZAE ROBERT STEICHEN 4940 BASCHARAGE Zobacz na mapie Rodzaj działalności Private for-profit entities (excluding Higher or Secondary Education Establishments) Kontakt administracyjny Richard Fry (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITE DE GENEVE Szwajcaria Wkład UE € 764 208,40 Adres RUE DU GENERAL DUFOUR 24 1211 Geneve Zobacz na mapie Region Schweiz/Suisse/Svizzera Région lémanique Genève Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Thierry Berney (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych AvantiCell Science Ltd Zjednoczone Królestwo Wkład UE € 875 023,40 Adres GIBBSYARD BUILDING KA6 5HW Ayr Zobacz na mapie Region Scotland Southern Scotland South Ayrshire Rodzaj działalności Private for-profit entities (excluding Higher or Secondary Education Establishments) Kontakt administracyjny Joanna Oliver (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych ISTITUTO MEDITERRANEO PER I TRAPIANTI E TERAPIE AD ALTA SPECIALIZZAZIONE SRL - ISMETT SRL Włochy Wkład UE € 855 653,00 Adres DISCESA DEI GIUDICI 4 90133 Palermo Zobacz na mapie Region Isole Sicilia Palermo Rodzaj działalności Other Kontakt administracyjny Fabrizio Campisi (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych