Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope

Project Information

EU-CERT-ICD

Grant agreement ID: 602299

Project closed

Start date 1 October 2013

End date 30 September 2018

Funded under

• Specific Programme "Cooperation": Health

Total cost € 7 674 687,79

EU contribution € 5 999 562,00

Coordinated by

UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Germany

Objective

An estimated 500.000 sudden cardiac deaths (SCD) occur each year in the European Union. Patients at risk for SCD may benefit from prophylactic treatment with an implantable cardioverter-defibrillator (ICD). ICD implantations have dramatically increased in recent years leading to multi-billion Euros of costs with significant regional disparities across Europe. Information on risks, benefits and costs supporting current guideline recommendations may be outdated, and the influence of gender remains unclear.
EU-CERT-ICD (Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in Europe) aims to generate contemporary clinical outcome data on ICD effectiveness in Europe. Clinical outcomes including all-cause mortality, appropriate and inappropriate ICD shocks, and quality of life (QoL) are assessed by:
- a prospective study of patients undergoing indicated ICD treatment for primary SCD prevention, with a control group of patients not undergoing ICD treatment
- a large European registry collecting available data on prophylactic ICD treatment
- meta-analyses of available and emerging ICD outcome studies
QoL-adjusted cost-effectiveness will be estimated from actual cost comparisons and Markov decision models with attention to sub-groups, regional, and sex comparisons. Outcomes in patients receiving ICDs for primary SCD prevention will be compared in sub-strata, and with patients fulfilling guideline criteria but not undergoing therapy as per prior decision of treating physicians. Sub-groups with particularly large or small benefit from ICD implantation will be identified using risk markers and clinical characteristics with specific emphasis on gender. EU-CERT-ICD is expected to provide important novel information to validate or challenge current guideline indications for primary prophylactic ICD treatment.

Fields of science

Not validated

• social sciences › sociology › demography › mortality

Programme(s)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Topic(s)

• HEALTH.2013.2.4.2-2 - Comparative effectiveness research of existing technologies for prevention, diagnosis and treatment of cardiovascular diseases

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS

• EU contribution: € 2 290 586,24
• Address: Robert-Koch-Strasse 40 ; 37075 Goettingen ; Germany
• Region: Niedersachsen › Braunschweig › Göttingen
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Christiane Hennecke (Mrs.)
• Total cost: No data

Participants (25)

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands

• EU contribution: € 345 613,20
• Address: HEIDELBERGLAAN 100 ; 3584 CX Utrecht
• Region: West-Nederland › Utrecht › Utrecht
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Karin Krol-Simons (Mrs.)
• Total cost: No data

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Germany

• EU contribution: € 70 440,00
• Address: GESCHWISTER-SCHOLL-PLATZ ; 72074 Tuebingen
• Region: Baden-Württemberg › Tübingen › Tübingen, Landkreis
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Axel Bauer (Prof.)
• Total cost: No data

KAROLINSKA INSTITUTET

Sweden

• EU contribution: € 44 763,60
• Address: Nobels Vag 5 ; 17177 Stockholm
• Region: Östra Sverige › Stockholm › Stockholms län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Caroline Hamilton (Ms.)
• Total cost: No data

CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER

Spain

• EU contribution: € 144 100,80
• Address: CALLE ROSSELLO 149 PUERTA BJS ; 08036 Barcelona
• Region: Este › Cataluña › Barcelona
• Activity type: Other
• Administrative Contact: Pastora Martinez Samper (Dr.)
• Total cost: No data

PANEPISTIMIAKO GENIKO NOSOKOMEIO ATTIKON

Greece

• EU contribution: € 106 778,40
• Address: ODOS RIMINI 1 ; 12462 Athina Chaidari
• Region: Αττική › Aττική › Δυτικός Τομέας Αθηνών
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Administrative Contact: Panagiota Lazarou (Ms.)
• Total cost: No data

SLOVENSKA ZDRAVOTNICKA UNIVERZITA V BRATISLAVE

Slovakia

• EU contribution: € 73 416,00
• Address: LIMBOVA 12 ; 833 03 Bratislava
• Region: Slovensko › Bratislavský kraj › Bratislavský kraj
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Robert Hatala (Prof.)
• Total cost: No data

OULUN YLIOPISTO

Finland

• EU contribution: € 225 723,60
• Address: PENTTI KAITERAN KATU 1 ; 90014 Oulu
• Region: Manner-Suomi › Länsi-Suomi › Pohjanmaa
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Hanna Honkamakila (Mrs.)
• Total cost: No data

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

• EU contribution: € 263 338,80
• Address: GESCHWISTER SCHOLL PLATZ 1 ; 80539 MUNCHEN
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Moritz Sinner (Dr.)
• Total cost: No data

UNIVERSYTET MEDYCZNY W LODZI.

Poland

• EU contribution: € 228 649,20
• Address: Al. Kosciuszki, 4 ; 90419 Lodz
• Region: Makroregion centralny › Łódzkie › Łódzki
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Andrzej Lubinski (Prof.)
• Total cost: No data

ST. PAUL'S CARDIAC ELECTROPHYSIOLOGY LLP

United Kingdom

• EU contribution: € 139 814,40
• Address: VERULAM AVENUE 16 ; CR8 3NQ PURLEY
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Katerina Hnatkova (Dr.)
• Total cost: No data

SEMMELWEIS EGYETEM

Hungary

• EU contribution: € 269 733,60
• Address: ULLOI UTCA 26 ; 1085 Budapest
• Region: Közép-Magyarország › Budapest › Budapest
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Bela Merkely (Prof.)
• Total cost: No data

KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN

Germany

• EU contribution: € 314 916,00
• Address: ISMANINGER STRASSE 22 ; 81675 Muenchen
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Beate Schaulin (Ms.)
• Total cost: No data

UNIVERSITATSSPITAL BASEL

Switzerland

• EU contribution: € 256 549,20
• Address: HEBELSTRASSE 32 ; 4031 Basel
• Region: Schweiz/Suisse/Svizzera › Nordwestschweiz › Basel-Stadt
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Administrative Contact: Thilo Wieczorek (Mr.)
• Total cost: No data

REGION HOVEDSTADEN

Denmark

• EU contribution: € 249 133,20
• Address: KONGENS VAENGE 2 ; 3400 Hillerod
• Region: Danmark › Hovedstaden › Nordsjælland
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Administrative Contact: Christine Nuding (Ms.)
• Total cost: No data

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

• EU contribution: € 169 838,40
• Address: OUDE MARKT 13 ; 3000 Leuven
• Region: Vlaams Gewest › Prov. Vlaams-Brabant › Arr. Leuven
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Karolien Mariën (Ms.)
• Total cost: No data

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Germany

• EU contribution: € 478 800,00
• Address: Chariteplatz 1 ; 10117 Berlin
• Region: Berlin › Berlin › Berlin
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Eveline Fräßdorf (Ms.)
• Total cost: No data

GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG

Participation ended

Germany

• EU contribution: € 160 889,36
• Address: OSKAR VON MILLER RING 29 ; 80333 Muenchen
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Birgit Fuchs (Ms.)
• Total cost: No data

MAGDALENA - KLINIKA ZA KARDIOVASKULARNE BOLESTI MEDICINSKOG FAKULTETASVEUCILISTA J.J. STROSSMAYERA U OSIJEKU USTANOVA

Croatia

• EU contribution: € 67 778,00
• Address: LJUDEVITA GAJA 2 ; 49000 KRAPINSKE TOPLICE
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Petar Cota (Mr.)
• Total cost: No data

KLINIKEN LUDWIGSBURG-BIETIGHEIM GGMBH

Germany

• EU contribution: € 12 300,00
• Address: POSILIPOSTRASSE 4 ; 71640 LUDWIGSBURG
• Activity type: Other
• Administrative Contact: Pia Rey-Hinterkopf
• Total cost: No data

FAKULTNI NEMOCNICE BRNO

Czechia

• EU contribution: € 26 400,00
• Address: JIHLAVSKA 20 ; 625 00 Brno
• Region: Česko › Jihovýchod › Jihomoravský kraj
• Activity type: Research Organisations
• Administrative Contact: Marie Hrdinkova
• Total cost: No data

REGION SKANE

Participation ended

Sweden

• EU contribution: No data
• Address: REGION SKANE ; 291 89 Kristianstad
• Region: Södra Sverige › Sydsverige › Skåne län
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Administrative Contact: Pyotr G Platonov (Prof.)
• Total cost: No data

STREDOSLOVENSKY USTAV SRDCOVYCH A CIEVNYCH CHOROB AS

Slovakia

• EU contribution: € 16 800,00
• Address: CESTA K NEMOCNICI 1 ; 97401 Banská Bystrica
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Renáta Capeková (Dr.)
• Total cost: No data

SZPITAL KLINICZNY IM HELIODORA SWIECICKIEGO UNIWERSYTETU MEDYCZNEGO IMKAROLA MARCINKOWSKIEGO W POZNANIU

Poland

• EU contribution: € 16 200,00
• Address: UL. PRZYBYSZEWSKIEGO 49 ; 60 355 POZNAN
• Activity type: Research Organisations
• Administrative Contact: Stanislaw Szczepaniak (Mr.)
• Total cost: No data

UNIVERZITA PALACKEHO V OLOMOUCI

Czechia

• EU contribution: € 21 600,00
• Address: KRIZKOVSKEHO 8 ; 771 47 Olomouc
• Region: Česko › Střední Morava › Olomoucký kraj
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Eva Strakova (Ms.)
• Total cost: No data

NARODOWY INSTYTUT KARDIOLOGII STEFANA KARDYNALA WYSZYNSKIEGO - PANSTWOWY INSTYTUT BADAWCZY

Poland

• EU contribution: € 5 400,00
• Address: UL. ALPEJSKA 42 ; 04 628 Warszawa
• Region: Makroregion województwo mazowieckie › Warszawski stołeczny › Miasto Warszawa
• Activity type: Research Organisations
• Administrative Contact: Maciej Miłkowski (Mr.)
• Total cost: No data