Skip to main content

Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope

Objective

An estimated 500.000 sudden cardiac deaths (SCD) occur each year in the European Union. Patients at risk for SCD may benefit from prophylactic treatment with an implantable cardioverter-defibrillator (ICD). ICD implantations have dramatically increased in recent years leading to multi-billion Euros of costs with significant regional disparities across Europe. Information on risks, benefits and costs supporting current guideline recommendations may be outdated, and the influence of gender remains unclear.
EU-CERT-ICD (Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in Europe) aims to generate contemporary clinical outcome data on ICD effectiveness in Europe. Clinical outcomes including all-cause mortality, appropriate and inappropriate ICD shocks, and quality of life (QoL) are assessed by:
- a prospective study of patients undergoing indicated ICD treatment for primary SCD prevention, with a control group of patients not undergoing ICD treatment
- a large European registry collecting available data on prophylactic ICD treatment
- meta-analyses of available and emerging ICD outcome studies
QoL-adjusted cost-effectiveness will be estimated from actual cost comparisons and Markov decision models with attention to sub-groups, regional, and sex comparisons. Outcomes in patients receiving ICDs for primary SCD prevention will be compared in sub-strata, and with patients fulfilling guideline criteria but not undergoing therapy as per prior decision of treating physicians. Sub-groups with particularly large or small benefit from ICD implantation will be identified using risk markers and clinical characteristics with specific emphasis on gender. EU-CERT-ICD is expected to provide important novel information to validate or challenge current guideline indications for primary prophylactic ICD treatment.

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Address
Robert-koch-strasse 40
37075 Goettingen
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 290 586,24
Administrative Contact
Christiane Hennecke (Mrs.)

Participants (25)

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 345 613,20
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Karin Krol-Simons (Mrs.)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 70 440
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Axel Bauer (Prof.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 44 763,60
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Caroline Hamilton (Ms.)
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain
EU contribution
€ 144 100,80
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Activity type
Other
Administrative Contact
Pastora Martinez Samper (Dr.)
PANEPISTIMIAKO GENIKO NOSOKOMEIO ATTIKON
Greece
EU contribution
€ 106 778,40
Address
Odos Rimini 1
12462 Athina Chaidari
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Panagiota Lazarou (Ms.)
SLOVENSKA ZDRAVOTNICKA UNIVERZITA V BRATISLAVE
Slovakia
EU contribution
€ 73 416
Address
Limbova 12
83303 Bratislava
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Robert Hatala (Prof.)
OULUN YLIOPISTO
Finland
EU contribution
€ 225 723,60
Address
Pentti Kaiteran Katu 1
90014 Oulu
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Hanna Honkamakila (Mrs.)
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 263 338,80
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Moritz Sinner (Dr.)
UNIVERSYTET MEDYCZNY W LODZI.
Poland
EU contribution
€ 228 649,20
Address
Al. Kosciuszki, 4
90419 Lodz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andrzej Lubinski (Prof.)
ST. PAUL'S CARDIAC ELECTROPHYSIOLOGY LLP
United Kingdom
EU contribution
€ 139 814,40
Address
Verulam Avenue 16
CR8 3NQ Purley
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Katerina Hnatkova (Dr.)
SEMMELWEIS EGYETEM
Hungary
EU contribution
€ 269 733,60
Address
Ulloi Utca 26
1085 Budapest
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Bela Merkely (Prof.)
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Germany
EU contribution
€ 314 916
Address
Ismaninger Strasse 22
81675 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Beate Schaulin (Ms.)
UNIVERSITATSSPITAL BASEL
Switzerland
EU contribution
€ 256 549,20
Address
Hebelstrasse 32
4031 Basel
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Thilo Wieczorek (Mr.)
REGION HOVEDSTADEN
Denmark
EU contribution
€ 249 133,20
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Christine Nuding (Ms.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 169 838,40
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Karolien Mariën (Ms.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 478 800
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Fräßdorf (Ms.)
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG

Participation ended

Germany
EU contribution
€ 160 889,36
Address
Oskar Von Miller Ring 29
80333 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Fuchs (Ms.)
MAGDALENA - KLINIKA ZA KARDIOVASKULARNE BOLESTI MEDICINSKOG FAKULTETASVEUCILISTA J.J. STROSSMAYERA U OSIJEKU USTANOVA
Croatia
EU contribution
€ 67 778
Address
Ljudevita Gaja 2
49000 Krapinske Toplice
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Petar Cota (Mr.)
KLINIKEN LUDWIGSBURG-BIETIGHEIM GGMBH
Germany
EU contribution
€ 12 300
Address
Posilipostrasse 4
71640 Ludwigsburg
Activity type
Other
Administrative Contact
Pia Rey-Hinterkopf
FAKULTNI NEMOCNICE BRNO
Czechia
EU contribution
€ 26 400
Address
Jihlavska 20
625 00 Brno
Activity type
Research Organisations
Administrative Contact
Marie Hrdinkova
SKANE LANS LANDSTING

Participation ended

Sweden
Address
.
291 89 Kristianstad
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Pyotr G Platonov (Prof.)
STREDOSLOVENSKY USTAV SRDCOVYCH A CIEVNYCH CHOROB AS
Slovakia
EU contribution
€ 16 800
Address
Cesta K Nemocnici 1
97401 Banská Bystrica
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Renáta Capeková (Dr.)
SZPITAL KLINICZNY IM HELIODORA SWIECICKIEGO UNIWERSYTETU MEDYCZNEGO IMKAROLA MARCINKOWSKIEGO W POZNANIU
Poland
EU contribution
€ 16 200
Address
Ul. Przybyszewskiego 49
60 355 Poznan
Activity type
Research Organisations
Administrative Contact
Stanislaw Szczepaniak (Mr.)
UNIVERZITA PALACKEHO V OLOMOUCI
Czechia
EU contribution
€ 21 600
Address
Krizkovskeho 8
771 47 Olomouc
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eva Strakova (Ms.)
INSTYTUT KARDIOLOGII IM. PRYMASA TYSIACLECIA STEFANA KARDYNALA WYSZYNSKIEGO
Poland
EU contribution
€ 5 400
Address
Ul. Alpejska 42
04628 Warszawa
Activity type
Research Organisations
Administrative Contact
Maciej Miłkowski (Mr.)