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Systems biology for the functional validation of genetic determinants of skeletal diseases

Objective

"The aim of SYBIL is to carry out extensive functional validation of the genetic determinants of rare and common skeletal diseases and the age related factors contributing to these painful conditions. To achieve this goal SYBIL will gather complementary translational and transnational scientists, systems biologists, disease modellers, leading SMEs and industrialists that will perform in-depth characterisation (complete molecular phenotyping) of pre-clinical models (cellular and animal) for a variety of common and rare skeletal diseases. SYBIL will establish a systematic pipeline of in vitro, ex vivo and in vivo models of increasing complexity and will also make use of novel technologies such as iPS cells and exclusive ‘Virtual Patient’ software to identify potential therapeutic targets for further validation through simultaneous modelling of fundamental and complex physiological pathways. SYBIL will rely on i) an ‘Omics Knowledge Factory’ for systematically generating new knowledge on skeletal disease pathophysiology and to generate the relevant Omics profiles necessary to detect and validate new disease determinants, biomarkers and therapeutic targets for future clinical developments, and ii) a “Systems Biology Hub” to integrate the high-throughput and data-dense information, to gain a global understanding of pathophysiological commonalities between different skeletal diseases and recognize predominant shared pathways and mechanisms that may represent new targeted routes to treatment. SYBIL will also identify potential modifier genes and study the epigenome that will ultimately influence the timing and efficacy of new personalised treatments. Overall SYBIL achievements will tremendously boost the efficient pre-clinical assessment and development of therapeutics against skeletal diseases and thus indirectly reduce their social and healthcare burden."

Field of science

  • /medical and health sciences/basic medicine/physiology/pathophysiology
  • /natural sciences/computer and information sciences/software

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSITY OF NEWCASTLE UPON TYNE
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 324 244
Administrative Contact
Rory Deane (Mr.)

Participants (17)

UNIVERSITA DEGLI STUDI DELL'AQUILA
Italy
EU contribution
€ 638 400
Address
Piazza Santa Margherita 2
67100 L Aquila
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anna Maria Teti (Prof.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 1 183 954
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Claire Faichnie (Ms.)
ALACRIS THERANOSTICS GMBH
Germany
EU contribution
€ 666 516
Address
Max Planck Strasse 3
12489 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Hildrun Plaetschke (Ms.)
UNIVERSITA DEGLI STUDI DI PAVIA
Italy
EU contribution
€ 576 100
Address
Strada Nuova 65
27100 Pavia
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sofia Baggini (Dr.)
POLYGENE AG
Switzerland
EU contribution
€ 832 400
Address
Riedmattstrasse 9
8153 Rümlang
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Doron Shmerling (Dr.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 469 800
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
Administrative Contact
Federica Rapposelli (Dr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 892 918
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Céline Gaborit (Mrs.)
CERTUS TECHNOLOGY ASSOCIATES LIMITED
United Kingdom
EU contribution
€ 477 660
Address
Abbey Road 9 Mount Pleasant
EX4 7BG Exeter
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ian Bamsey (Mr.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 576 000
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Frässdorf (Mrs.)
Eurofins Genomics Europe Sequencing GmbH
Germany
EU contribution
€ 849 780
Address
Jakob Stadler Platz 7
78467 Konstanz
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Natascha Ostrowski (Mrs.)
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
EU contribution
€ 479 100
Address
Martinistrasse 52
20251 Hamburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael Amling (Prof.)
EVERCYTE GMBH
Austria
EU contribution
€ 430 598,40
Address
Muthgasse 18
1190 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Regina Grillari (Dr.)
KLINIKUM DER UNIVERSITAET ZU KOELN
Germany
EU contribution
€ 480 000
Address
Kerpener Strasse 62
50937 Koeln
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Petra Schreiner-Kaub (Mrs.)
PRIMM SRL
Italy
EU contribution
€ 699 200
Address
Via Olgettina 58
20132 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Paolo Sarmientos (Dr.)
UNIVERSITAETSKLINIKUM FREIBURG
Germany
EU contribution
€ 554 300,40
Address
Hugstetter Strasse 49
79106 Freiburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gerhard Henninger (Mr.)
UNIVERSITEIT ANTWERPEN
Belgium
EU contribution
€ 498 000
Address
Prinsstraat 13
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Adams (Mrs.)
FINOVATIS
France
EU contribution
€ 339 598,20
Address
Cours Lafayette 68
69003 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
David Koubi (Dr.)