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Biomarker Development for Postoperative Cognitive Impairment in the Elderly

Objective

Postoperative delirium (POD) is characterized by the progressive deterioration of sensory/cognitive function after surgery with incidences of up to 30-80%. It is frequently followed by postoperative cognitive dysfunction (POCD) which tends to persist over time. In elderly patients, POCD resembles chronic dementia and appears to accelerate the cognitive decline in Alzheimer dementia. POD is strongly associated with subsequent dementia after 3.2 and 5.0 years of follow-up: odds ratio = 12.52 [95% CI, 1.86-84.21] corrected for baseline dementia, severity of illness, age. In an aging society like the EU, the socioeconomic implications of POD/POCD are therefore profound. At present no treatment exists and there are no established molecular or imaging biomarkers that allow risk and clinical outcome prediction. We will establish valid biomarkers panels for risk and clinical outcome prediction of POD/POCD in N=1200 surgical patients according to the regulatory requirements of the European Medicines Agency. Thus, a valuable database will be created not yet existing worldwide. Neuroimaging investigations, which directly provide information on brain structure/function, will include structural magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), arterial spin labelling (ASL), functional magnetic resonance imaging with simultaneous electrophysiology (fMRI/EEG) and glutamate MR-spectroscopy (MRS). These investigations will be complemented by genetic/gene expression analyses (sequencing of cholinergic candidate genes/corresponding transcripts) and analyses of plasma and cerebrospinal fluid markers (inflammatory/metabolic). Supported by bioinformatics approaches, integration of neuroimaging data with knowledge from molecular biomarkers (multivariate expert system) is expected to allow patient stratification. This will greatly support decision-making before surgical intervention (balancing benefits and risks) as well as the development of novel therapies in POD/POCD.

Field of science

  • /medical and health sciences/clinical medicine/surgery
  • /medical and health sciences/clinical medicine/radiology/medical imaging/magnetic resonance imaging
  • /medical and health sciences/basic medicine/neurology/alzheimer

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Address
Chariteplatz 1
10117 Berlin
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 276 800
Administrative Contact
Mara-Theresa Klein (Ms.)

Participants (11)

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 886 600
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marieke Krispijn (Dr.)
Cambridge University Hospitals NHS Foundation Trust
United Kingdom
EU contribution
€ 150 000
Address
Hills Road Addenbrookes Hospital
CB2 0QQ Cambridge
Activity type
Other
Administrative Contact
Evgeny Dmitriev (Mr.)
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
Germany
EU contribution
€ 988 400
Address
Robert Rossle Strasse 10
13125 Berlin
Activity type
Research Organisations
Administrative Contact
Ioannis Legouras (Dr.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 264 000
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
Administrative Contact
Diana Boraschi (Dr.)
UNIVERSITE DU LUXEMBOURG
Luxembourg
EU contribution
€ 390 300
Address
2 Avenue De L'universite
4365 Esch-sur-alzette
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rudi Balling (Prof.)
ATLAS BIOLABS GMBH
Germany
EU contribution
€ 625 500
Address
Kerpener Strasse 61-69
50937 Koln
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Peter Nürnberg (Prof.)
PHARMAIMAGE BIOMAKER SOLUTIONS GmbH
Germany
EU contribution
€ 830 800
Address
Milanstrasse 3
40882 Ratingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Georg Winterer (Prof.)
IMMUNDIAGNOSTIK AG
Germany
EU contribution
€ 300 000
Address
Stubenwald Allee 8 A
64625 Bensheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nicole Pohl (Dr.)
ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU
Italy
EU contribution
€ 150 000
Address
Via Fiorentina 151
53100 Siena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Cristiana Tozzi (Dr.)
CELLOGIC GMBH
Germany
EU contribution
€ 50 000
Address
Niedstrasse 21
12159 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Malte Pietzsch (Dr.)
PHYSIKALISCH-TECHNISCHE BUNDESANSTALT
Germany
EU contribution
€ 70 000
Address
Bundesallee 100
38116 Braunschweig
Activity type
Research Organisations
Administrative Contact
Maren Jachmann (Dr.)