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Mechanisms and Treatment of Migraine and its Chronification

Objective

Migraine is a common brain disorder, typically characterised by recurring, incapacitating attacks of 1-3 days of severe headache, autonomic dysfunction, and sometimes aura symptoms. The disease affects 15% of all European citizens including children, ranks among the WHO top 12 of most disabling and undertreated disorders, and is responsible for the highest socio-economic burden of any brain ailment in Europe.

Migraine attacks typically strike bi-monthly, and in 25% of patients once a week or more. Many patients may progress to “chronic migraine” with near-daily headaches and high disability (chronification). There is desperate need of effective prophylactic treatments to prevent attacks and chronification. Current medications are only moderately effective and often poorly tolerated, mainly due to lack of understanding of how attacks are triggered and why their frequency may increase so dramatically. Overuse of painkillers and triptans, are recognised risk factors for chronification, as are comorbid depression, stress, and obesity. Central sensitisation of pain signalling pathways appears to be pivotal to the chronification proces.

EUROHEADPAIN will use established and evolving human and translational animal models to: (a) identify pathways and biomarkers for the triggering and chronification of migraine attacks; (b) decipher the modulatory effects of (hypothalamic) brain circuitries on trigeminal processing, sensitisation, and chronification; (c) assess the effects and mode of action of migraine-provoking molecules; and (d) evaluate the efficacy and mode of action of neuromodulation (in collaboration with an SME) and second messenger-blocking drugs in the treatment of chronic migraine. We expect important spin-offs to the understanding of other chronic pain disorders. The pharmaceutical industry will be engaged once treatable targets have been identified to develop novel treatments to reduce the disability and socio-economic burden due to migraine.

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

ACADEMISCH ZIEKENHUIS LEIDEN
Address
Albinusdreef 2
2333 ZA Leiden
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 511 738
Administrative Contact
Linda Ouwerkerk (Mrs.)

Participants (13)

UNIVERSITE DE LIEGE
Belgium
EU contribution
€ 592 544
Address
Place Du 20 Aout 7
4000 Liege
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Isabelle Halleux (Mrs.)
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
EU contribution
€ 468 440
Address
Martinistrasse 52
20251 Hamburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Arne May (Prof.)
GENOME RESEARCH LIMITED

Participation ended

United Kingdom
Address
The Gibbs Building, Euston Road 215
NW1 2BE London
Activity type
Research Organisations
Administrative Contact
David Davison (Mr.)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 1 039 364
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mika Frederiksen (Mr.)
QUEENSLAND INSTITUTE OF MEDICAL RESEARCH

Participation ended

Australia
Address
Herston Road, 300
QLD 4006 Herston
Activity type
Research Organisations
Administrative Contact
Lee Casey (Ms.)
SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE
Italy
EU contribution
€ 333 680
Address
Via Bonomea 265
34136 Trieste
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gabriele Rizzetto (Mr.)
FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG
Germany
EU contribution
€ 552 680
Address
Schlossplatz 4
91054 Erlangen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Franziska Müller (Ms.)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Participation ended

United States
Address
Franklin Street 1111, 12 Floor
94607 Oakland Ca
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michelle Mcginley (Ms.)
REGION HOVEDSTADEN
Denmark
EU contribution
€ 711 320
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Kirsten Hjelm (Ms.)
CEFALY TECHNOLOGY
Belgium
EU contribution
€ 121 640
Address
Zi Des Hauts Sarts 4E Avenue 5
4040 Herstal
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Pierre Rigaux (Mr.)
SZEGEDI TUDOMANYEGYETEM
Hungary
EU contribution
€ 170 960
Address
Dugonics Ter 13
6720 Szeged
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gabor Antal (Mr.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 494 360
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labbett (Mr.)
QUEENSLAND UNIVERSITY OF TECHNOLOGY - QLD QUT
Australia
Address
George Street 2
4001 Brisbane
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Vanessa Scott (Mrs.)