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Aggression in Children: Unraveling gene-environment interplay to inform Treatment and InterventiON strateg

Objective

Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. Despite large scientific, preventive, and treatment investments, no decrease in aggressive behavior is seen. This calls for a shift to new approaches. By capitalising on comprehensive longitudinal cohorts, recent advances in genetic, biological, epidemiological, and clinical fields, and combining such interdisciplinary expertise the ACTION consortium will dissect the etiology and pathogenesis of aggression. Based on new insights, ACTION will inform the development of novel diagnostic tools and causative targets and guide the development of treatment and prevention strategies. ACTION is built on interrelated work packages with a focus on a) clinical epidemiology and current classification and treatment problems; b) genetic epidemiology, including Genome Wide Association studies and epigenetics; c) gene-environment correlation and interaction; d) biomarkers and metabolomics. ACTION will deliver an overarching framework that combines a thorough understanding of pathways leading to aggression with a map of current gaps, best practices on clinical, ethical, legal, and social issues. Based on this framework, ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.

Field of science

  • /social sciences/sociology/social problems
  • /natural sciences/biological sciences/genetics and heredity/genome
  • /medical and health sciences/health sciences/epidemiology

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

STICHTING VU
Address
De Boelelaan 1105
1081 HV Amsterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 697 458,65
Administrative Contact
Martin Van Aken (Mr.)

Participants (11)

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 392 100
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Robert Vermeiren (Prof.)
QUEENSLAND INSTITUTE OF MEDICAL RESEARCH
Australia
Address
Herston Road, 300
QLD 4006 Herston
Activity type
Research Organisations
Administrative Contact
Nick Martin (Prof.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 501 280
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Agneta Häggström (Ms.)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 496 720,40
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kaisa Ainala (Ms.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 550 182,80
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labbett (Mr.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 278 700
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jip Chong (Mr.)
University of Notre Dame du Lac
United States
EU contribution
€ 270 009
Address
Main Building 511
46556 Notre Dame
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gitta Lubke (Dr.)
UNIVERSITA DEGLI STUDI DI CAGLIARI
Italy
EU contribution
€ 475 946,60
Address
Via Universita 40
09124 Cagliari
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Vassilios Fanos (Prof.)
DIAGENODE

Participation ended

Belgium
EU contribution
€ 22 266,75
Address
Rue Du Bois Saint Jean 3 Liege Park Science
4102 Seraing
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Helene Pendeville (Dr.)
GOOD BIOMARKER SCIENCES BV
Netherlands
EU contribution
€ 894 963,20
Address
Teijlingerlaan 59
2171 CD Sassenheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Cornelis Kluft (Prof.)
UNIVERSITEIT LEIDEN
Netherlands
EU contribution
€ 419 452
Address
Rapenburg 70
2311 EZ Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ton Brouwer (Mr.)