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The development of a novel therapeutic vaccine for the selective treatment of the autoimmune disorder, Graves’ disease

Objective

This aim of the DAVIAD proposal is to develop a therapeutic vaccine for Graves’ disease (GD) that has a better safety and efficacy profile than current treatments. There is a high level of unmet need in the treatment of Graves’ disease especially in patients with Graves orbitopathy and children and adolescents (who generally suffer from the most chronic form of the disease). Autoimmune diseases arise as a consequence of a hypersensitive response to self antigens. This proposal focuses on the development of an antigen specific vaccine therapy to reinstate immune tolerance to Graves’ disease. The selected peptides behave as apitopes (antigen processing independent epitopes) and bind to MHC class II molecules in the correct confirmation to induce tolerance. In the first instance DAVIAD will further characterise antigen specific peptides (based on the autoantigen associated with the disease) already selected using a validated discovery platform. DAVIAD will generate translational data to support a clinical trial application, conduct disease model studies and prepare the clinical trial application. DAVIAD will design and conduct a phase I/IIa trial in GD patients to show that efficacy and safety compare favourably with current treatments and those in development. The consortium has the expertise required to effectively and efficiently take the proposed vaccine through clinical development and eventual commercialisation. A disease modifying vaccine for GD will address a serious unmet need and potentially offer a therapy that can change the way this disease is treated, offering better quality of life for sufferers and reducing burden on health services.

Field of science

  • /social sciences/sociology/governance/public services

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

APITOPE INTERNATIONAL NV
Address
Agoralaan A Bis
3590 Diepenbeek
Belgium
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 3 539 839,50
Administrative Contact
Luc Lammens (Mr.)

Participants (3)

QUINTILES BENEFIT FRANCE INC
France
EU contribution
€ 885 609
Address
Rue Maurice Ravel 3/5
92594 Levallois Perret Cedex
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gary Johnson (Mr.)
KWS BIOTEST LIMITED
United Kingdom
EU contribution
€ 1 484 683,50
Address
Medical Sciences Building University Walk
BS8 1TD Bristol
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Neil Williams (Prof.)
GLAXOSMITHKLINE BIOLOGICALS SA

Participation ended

Belgium
EU contribution
€ 14 761
Address
Rue De L Institut 89
1330 Rixensart
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Philippe Denoel (Dr.)