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Targeting cardiac fibrosis for heart failure treatment

Objective

The Fibro-Targets project is a multi-disciplinary 4 years program involving 10 partners ambitioning “the identification, characterisation and validation of in vitro and in vivo models of novel therapeutically relevant targets” for myocardial interstitial fibrosis (MIF) in heart failure. The project is based on the hypothesis that the intervention on novel fibrosis-related targets involved in the processes of fibroblast differentiation to myofibroblasts, the predominance of collagen synthesis over degradation and/or collagen maturation may allow for interstitial repair, thus providing a new strategy for the prevention and treatment of adverse cardiac remodeling involved in the transition to and the progression of heart failure. From a large body of existing multi-omics, literature data and previous hypothesis-driven research conducted by members of the consortium, a number of specific extracellular and intracellular targets have been identified whose involvement in MIF is beginning to be understood and that may be targeted by specific therapies.
The specific aims of the Fibro-Targets are:
(i) To provide further evidence on the mechanisms of action of the above targets
(ii) To validate experimentally that new anti-fibrotic strategies can be developed based on the above targets
(iii) To approach the potential clinical scenario of the above targets for HF therapy
To reach these aims the following studies will be performed:
(i) Observational and interventional experimental studies in already existing and/or de novo generated appropriate in vitro and in vivo models.
(ii) Clinical studies, stratifying large scale populations of patients available to the consortium, at risk to develop HF and likely to be responsive to specific novel and/or exiting anti-fibrotic therapies. The stratification will be based on specific “fibrogenetic” phenotypic profiles using multi-panel imaging and circulating markers descriptive of mechanisms involving the proposed novel targets.

Field of science

  • /humanities/languages and literature/literature - general

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
EU contribution
€ 1 050 010
Administrative Contact
Marie-Ange Luc (Ms.)

Participants (10)

INSERM TRANSFERT SA
France
EU contribution
€ 400 000
Address
Rue Watt 7
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Louis Jammayrac (Mr.)
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA
Spain
EU contribution
€ 600 000
Address
Avenida De Pio Xii 55
31008 Pamplona
Activity type
Research Organisations
Administrative Contact
Andrew Solomon (Dr.)
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
EU contribution
€ 200 000
Address
Belfield
4 Dublin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Donal Doolan (Mr.)
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 500 000
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rob Van Der Zander (Mr.)
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 500 000
Address
Carl-neuberg-strasse 1
30625 Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Dittrich (Mr.)
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 680 000
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gerald Maurer (Prof.)
GREENPHARMA S.A.
France
EU contribution
€ 390 000
Address
Allée Du Titane 3
45100 Orléans
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Quoc Tuan Do (Dr.)
FIRALIS
France
EU contribution
€ 960 000
Address
Rue Du Fort 35
68330 Huningue
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Regine Will (Ms.)
Innovative Technologies in Biological Systems
Spain
EU contribution
€ 450 000
Address
Parque Tecnologico De Bizkaia 502-1
48160 Derio
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Isbaal Ramos (Prof.)
FUNDACION PUBLICA MIGUEL SERVET
Spain
EU contribution
€ 269 990
Address
Calle Irunlarrea 3 Centro Investigacion Biomedica Recinto Complejo Hospitalario De Navarra
31008 Pamplona
Activity type
Research Organisations
Administrative Contact
Maria Soledad Fragoso (Ms.)