Skip to main content

Multimodal Imaging of Neurological Disorders

Objective

The key concept behind this proposal is the development of a very high resolution and high efficiency brain dedicated Positron Emission Tomograph (PET) imager that can visualize neurotransmitter pathways and their disruptions in the quest to better diagnose and consequently to better treat schizophrenia. In addition, the plan is for this compact PET imager to be integrated with a Magnetic Resonance Imager Radio Frequency (MRI RF) system to be able to operate as a brain insert in a hybrid imaging setup with practically any MRI scanner.
From the technical point of view, we propose to optimize the PET technology for imaging of the human brain with the accuracy typically achieved for small animal brain imaging. To achieve this, we will incorporate the solid state based MRI-compatible PET modules that will be designed to achieve below systemic 1mm spatial resolution in a tomographic reconstruction of the human brain.
We aim to achieve the level of PET-MRI compatibility allowing for simultaneous PET and MRI imaging.
By combining PET measurements of neurotransmission with fMRI (functional MRI) measurements of Blood Oxygen Level Detection (BOLD) signal changes we will advance to a position where it is possible to learn more about the neurochemical determination of neural activity reflected in BOLD signal changes.
The novelty is that both the PET and RF coil systems are integrated into a portable and compact design dedicated to brain examination. This will allow current MR equipment to be easily upgraded into PET/MR systems.
To achieve its diagnostic goal, MINDView will be paired with the set of dedicated specific PET imaging agents and endogenous compounds that will be labeled with short-lived positron isotopes. The goal is that dopaminergic, glutamatergic and other pathways will be able to be studied with the new high performance imaging tool. Innovative paradigms such as activation and perturbation and their impact on brain function will be in focus.

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Address
Calle Serrano 117
28006 Madrid
Spain
Activity type
Research Organisations
EU contribution
€ 597 487
Administrative Contact
Guillermo Sanjuanbenito (Mr.)

Participants (9)

KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 468 784
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ylva Hultman (Ms.)
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Germany
EU contribution
€ 324 200
Address
Ismaninger Strasse 22
81675 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Renate Rädlein (Ms.)
BENCAR AB
Sweden
EU contribution
€ 417 300
Address
Dag Hammarkjold Vag 52B
75183 Uppsala
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Raymond Josephsson (Dr.)
GENERAL EQUIPMENT FOR MEDICAL IMAGING SA
Spain
EU contribution
€ 1 949 980
Address
Calle Jeronimo De Monsoriu, Num. 92 Planta Bj, Puerta Izq
46022 Valencia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marta Sáiz (Ms.)
SENSL TECHNOLOGIES LIMITED
Ireland
EU contribution
€ 483 800
Address
Building 6800 Avenue 6000 Cork Airport Business Park
- Cork
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
John Murphy (Dr.)
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 536 000
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lena Karlsson (Mrs.)
UNIVERSITE DE BRETAGNE OCCIDENTALE
France
EU contribution
€ 136 251
Address
Rue Des Archives 3
29238 Brest
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nathalie Queffelec (Mrs.)
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Italy
EU contribution
€ 136 250
Address
Piazzale Aldo Moro 5
00185 Roma
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Giancarlo Bertea (Mr.)
NORAS MRI PRODUCTS GMBH
Germany
EU contribution
€ 331 820
Address
Leibnizstrasse 4
97204 Hochberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Daniel Gareis (Mr.)