Skip to main content

Defining the role of xeno-directed and autoimmune events in patients receiving animal-derived bioprosthetic heart valves

Objective

TRANSLINK is a project devoted to assessing the mid-to long-term risk factors and improve the outcome of animal (bovine/porcine)-derived Bioprosthetic Heart Valve (BHV) implants. 300,000 patients/year benefit from BHV, a major healthcare problem (second most frequent cardiac surgery). BHV clinical outcome suffers from late dysfunctions restricting their application to older recipients. Based on a retrospective (already computerised) and prospective cohort of approximately 3,000 BHV recipients and control patients from 3 large EU cardiac surgery groups, TRANSLINK aims primarily to establish the possible role of recipients' immune response (IR) against BHV as a major cause to mid- to-long term clinical dysfunction. Precise molecular analysis of preimplantation BVH sugar moieties will be performed. Possible indirect side-effects on BHV endocarditis and host vessels inflammation are secondary end points. Serial and trans-sectional blood samples will be dispatched to a battery of highly specialised partner groups for testing anti-Gal, -Neu5Gc and -hyaluronic acid antibodies (Ig) using both validated and newly designed screening tools, glycan array patterns, and macrophages/NK responses. Data will be crossed with clinical outcome scores. Project design aims at delivering comprehensive recommendations in the time-frame of the grant. Fundamental basic science progress in the field of carbohydrate antigens is also expected. Furthermore, prevention (BHV from engineered animal source lacking major antigens) and treatment (bioabsorbants of deleterious Ig) oriented remedies as well as prospective biomarkers of longterm BHV deterioration will be set up by three first-class SMEs. TRANSLINK may strongly impact the treatment of heart valve diseases by improving morbid-mortality in patients with heart valves diseases and increasing the indication of BHV to younger patients.

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Coordinator

AZIENDA OSPEDALE UNIVERSITA PADOVA
Address
Via Nicolo Giustiniani 1
35128 Padova
Italy

See on map

Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Emanuele Cozzi (Dr.)
EU contribution
€ 531 176,53

Participants (13)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 161 137,39
Address
Rue De Tolbiac 101
75654 Paris

See on map

Activity type
Research Organisations
Administrative Contact
Gaëlle Baud (Ms.)
CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
France
EU contribution
€ 787 215,80
Address
Allee De L'ile Gloriette 5
44093 Nantes

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Brethet (Ms.)
INSTITUT CATALA DE LA SALUT
Spain
EU contribution
€ 588 619,65
Address
Gran Via De Les Corts Catalanes 587
08007 Barcelona

See on map

Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Laia Lagunas (Mrs.)
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
Spain
EU contribution
€ 282 021,99
Address
Avenida Gran Via Hospitalet 199-203
08908 L'hospitalet De Llobregat

See on map

Activity type
Research Organisations
Administrative Contact
Laia Lagunas (Mrs.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU contribution
€ 335 433,41
Address
Gower Street
WC1E 6BT London

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Malgorzata Kielbasa (Ms.)
TEL AVIV UNIVERSITY
Israel
EU contribution
€ 505 461,60
Address
Ramat Aviv
69978 Tel Aviv

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lea Pais (Ms.)
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 473 274,68
Address
Vasaparken
405 30 Goeteborg

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ellen Rydberg (Dr.)
AVANTEA srl
Italy
EU contribution
€ 1 054 789,22
Address
Via Cabrini 12
26100 Cremona

See on map

Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Giovanna Lazzari (Dr.)
INSTITUT UNIV DE CIENCIA I TECNOLOGIA SA
Spain
EU contribution
€ 704 052
Address
Calle Alvarez De Castro 63
08100 Mollet Del Valles

See on map

Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Roberto Horcajada Navas (Dr.)
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
EU contribution
€ 241 571,13
Address
Via 8 Febbraio 2
35122 Padova

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lorena Brogin (Ms.)
MIND THE BYTE SL
Spain
EU contribution
€ 131 484,60
Address
Calle Manso 76 Principal 1
08015 Barcelona

See on map

Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alfons Nonell-Canals (Dr.)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
EU contribution
€ 200 733
Address
Franklin Street 1111 12 Floor
94607 Oakland Ca

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ahmad Hakim-Elahi (Mr.)
UNIVERSITY OF MANITOBA
Canada
Address
Administration Building Room 202
R3T 2N2 Manitoba

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Colin Nicolson (Mr.)