Objetivo
Asymptomatic vascular damage accumulates for years before patients are identified and subjected to therapeutic measures. The limited knowledge on early vascular disease pathophysiology is reflected in the lack of therapeutic options. SysVasc aims to overcome this limitation by mounting a comprehensive systems medicine approach to elucidate pathological mechanisms, which will yield molecular targets for therapeutic intervention.
The consortium is based on established multidisciplinary European research networks, including specialists in pre-clinical and clinical research, omics technologies, and systems biology from research intensive SMEs and academia; partners synergistically provide access to an extensive number of selected population-based cohorts and associated datasets, cutting edge modeling and simulation methods, and established cardiovascular disease (CVD) animal models and patient cohorts. The coordinated application of these tools and know-how will identify pathophysiological mechanisms and key molecules responsible for onset and progression of CVD and validate their potential to serve as molecular targets for therapeutic intervention. To this end, the consortium will also use unique resources to evaluate molecular homology between the available model systems and human disease, which will yield reliable essential preclinical research tools to explore proof of concepts for therapeutic intervention studies and ultimately translate relevant results into novel therapeutic approaches.
Collectively, SysVasc will identify and validate novel biology-driven key molecular targets for CVD treatment. Major scientific, societal and economic impact is expected including, but not limited to, providing a valuable resource to further CVD research, and enhance competitiveness of participating SMEs and European health industry in general by translating knowledge into “innovative services” in therapeutic target and drug research.
Ámbito científico
Convocatoria de propuestas
FP7-HEALTH-2013-INNOVATION-1
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Régimen de financiación
CP-FP - Small or medium-scale focused research projectCoordinador
8010 Graz
Austria
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Participantes (18)
30659 Hannover
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85764 Neuherberg
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G12 8QQ Glasgow
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75654 Paris
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3104 Melbourne
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M13 9PL Manchester
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4 Dublin
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115 27 Athina
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72074 Tuebingen
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1206 Geneve
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V6T1Z1 Vancouver
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6020 Innsbruck
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CB10 1DR Cambridge
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2333 BZ LEIDEN
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1030 Wien
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PL4 8AA Plymouth
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10117 Berlin
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2333 BZ Leiden
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