Obiettivo In situ tissue engineering using a biodegradable synthetic scaffold that recruits endogenous cells from the bloodstream is emerging as a promising technology to create living heart valves inside the human body having the potential to last a life-time: one valve for life. Compared to classical tissue engineered heart valves this new technology demonstrates off-the-shelf availability at substantially reduced cost. The current proposal aims to further develop the synthetic biomaterials needed for the in situ tissue engineering of heart valves, to process these materials into a functional heart valve scaffold, and to perform all the necessary pre-clinical experiments to enable first-in-man clinical application. A novel approach to the biodegradable scaffold will be developed, that combines a relatively slowly degrading (months) elastomeric material with a fast degrading (weeks) bioactive hydrogel material. These materials will be processed into a fibrous heart valve scaffold by means of electrospinning. The elastomeric material ensure long term functionality of the valve while supporting in-vivo mature tissue formation, while the fast eroding hydrogel material controls the early inflammatory response and creates the necessary void space between the elastomeric fibers. A minimally invasive, transapical, implantation technique will be used for the placement of the heart valve scaffold at the aortic position, following our recent results. For this purpose, tailor-made stents will be developed. Campo scientifico engineering and technologymaterials engineeringfibersmedical and health sciencesmedical biotechnologytissue engineeringengineering and technologyindustrial biotechnologybiomaterials Programma(i) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Argomento(i) NMP.2013.2.2-1 - Biomaterials for Advanced Therapies and Medical Devices in the neurological/neuromuscular or cardiovascular fields Invito a presentare proposte FP7-NMP-2013-SME-7 Vedi altri progetti per questo bando Meccanismo di finanziamento CP-TP - Collaborative Project targeted to a special group (such as SMEs) Coordinatore TECHNISCHE UNIVERSITEIT EINDHOVEN Contributo UE € 1 440 313,00 Indirizzo GROENE LOPER 3 5612 AE Eindhoven Paesi Bassi Mostra sulla mappa Regione Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Leon Luwijs (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (6) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto SUPRAPOLIX BV Paesi Bassi Contributo UE € 763 800,00 Indirizzo HORSTEN 1 MMP 1.29 5612 AX Eindhoven Mostra sulla mappa Regione Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Anton Bosman (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITAT ZURICH Svizzera Contributo UE € 1 451 404,00 Indirizzo RAMISTRASSE 71 8006 Zurich Mostra sulla mappa Regione Schweiz/Suisse/Svizzera Zürich Zürich Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Simon Philipp Hoerstrup (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato JENAVALVE TECHNOLOGY GMBH Partecipazione conclusa Germania Contributo UE € 51 291,43 Indirizzo GUERICKESTRASSE 25 80805 MUNCHEN BAYERN Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Martin Schlun (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato MEDICUT STENT TECHNOLOGY GMBH Germania Contributo UE € 823 080,00 Indirizzo WILHELM BECKER STRASSE 11A 75179 PFORZHEIM Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Christian Herzog (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato APPLETREE CI GROUP AG Svizzera Contributo UE € 314 292,00 Indirizzo RUDOLF DIESEL STRASSE 3 8404 WINTERTHUR Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Rubén Ibáñez (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato XELTIS BV Paesi Bassi Contributo UE € 807 952,57 Indirizzo DE LISMORTEL 31 R2 06 CAT BUILD 5612 AR Eindhoven Mostra sulla mappa Regione Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Martijn Cox (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
