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Intelligent materials for in-situ heart Valve tissue engineering

Obiettivo

In situ tissue engineering using a biodegradable synthetic scaffold that recruits endogenous cells from the bloodstream is emerging as a promising technology to create living heart valves inside the human body having the potential to last a life-time: one valve for life. Compared to classical tissue engineered heart valves this new technology demonstrates off-the-shelf availability at substantially reduced cost. The current proposal aims to further develop the synthetic biomaterials needed for the in situ tissue engineering of heart valves, to process these materials into a functional heart valve scaffold, and to perform all the necessary pre-clinical experiments to enable first-in-man clinical application. A novel approach to the biodegradable scaffold will be developed, that combines a relatively slowly degrading (months) elastomeric material with a fast degrading (weeks) bioactive hydrogel material. These materials will be processed into a fibrous heart valve scaffold by means of electrospinning. The elastomeric material ensure long term functionality of the valve while supporting in-vivo mature tissue formation, while the fast eroding hydrogel material controls the early inflammatory response and creates the necessary void space between the elastomeric fibers. A minimally invasive, transapical, implantation technique will be used for the placement of the heart valve scaffold at the aortic position, following our recent results. For this purpose, tailor-made stents will be developed.

Invito a presentare proposte

FP7-NMP-2013-SME-7
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Coordinatore

TECHNISCHE UNIVERSITEIT EINDHOVEN
Indirizzo
Groene Loper 3
5612 AE Eindhoven
Paesi Bassi

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Leon Luwijs (Mr.)
Contributo UE
€ 1 440 313

Partecipanti (6)

SUPRAPOLIX BV
Paesi Bassi
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€ 763 800
Indirizzo
Horsten 1 Mmp 1.29
5612 AX Eindhoven

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Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Anton Bosman (Dr.)
UNIVERSITAT ZURICH
Svizzera
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€ 1 451 404
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Ramistrasse 71
8006 Zurich

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Simon Philipp Hoerstrup (Prof.)
JENAVALVE TECHNOLOGY GMBH

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Germania
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€ 51 291,43
Indirizzo
Guerickestrasse 25
80805 Munchen Bayern
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Martin Schlun (Mr.)
MEDICUT STENT TECHNOLOGY GMBH
Germania
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€ 823 080
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Wilhelm Becker Strasse 11a
75179 Pforzheim

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Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Christian Herzog (Mr.)
APPLETREE CI GROUP AG
Svizzera
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€ 314 292
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Rudolf Diesel Strasse 3
8404 Winterthur

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Rubén Ibáñez (Mr.)
XELTIS BV
Paesi Bassi
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€ 807 952,57
Indirizzo
De Lismortel 31 R2 06 Cat Build
5612 AR Eindhoven

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Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Martijn Cox (Dr.)