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Control of metabolic and inflammatory pathways by nuclear receptors

Objective

NR-NET is a multidisciplinary consortium, whose activities are directed towards the understanding of the role of Nuclear Receptors (NRs) and coregulators in metaflammatory disease. Metaflammation - metabolic disorders linked to chronic inflammation – is an emerging concept explaining the pathogenesis of a wide-spectrum of diseases. Since several nuclear receptors can directly sense metabolic alterations, we propose that they could be considered as important endogenous modulators of metaflammatory pathways further expanding the repertoire of diseases that can be intervened by NR-modulating drugs.
NR-NET is expected to deliver important new knowledge on the basic biological processes involved in the mechanism of epigenetic control of gene expression by nuclear receptors, on structural and functional aspects of nuclear receptor action with an ultimate goal of better understanding the pathogenesis of metabolic disorders and inflammation.
The composition of the network was designed to contain a balanced mix of labs with experience and skills in academic and industry based research, so that it can provide young researchers the opportunity to acquire skills and expertise in:
a. Structural and functional aspects of NR-regulated gene expression
b. Genomics and proteomics approaches to analyze complex regulatory networks
c. Systems biology approaches and bioinformatics tools to define composite regulatory modules
d. Studying metabolic and inflammatory pathways in model organisms
The research will be conducted under the framework of a structured training program, which includes a myriad of Individual and Network-wide training activities. Apart from training in academic and industry-based research projects, specific emphasis will be given to training in transferable skills and the stimulation of creativity and entrepreneurial mindset of researchers.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics

Call for proposal

FP7-PEOPLE-2013-ITN
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)

Coordinator

BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING
Address
Fleming Street 34
16672 Vari-athens
Greece
Activity type
Research Organisations
EU contribution
€ 757 301,02
Administrative Contact
Iannis Talianidis (Dr.)

Participants (9)

UNIVERSITY OF LEICESTER
United Kingdom
EU contribution
€ 481 694,40
Address
University Road
LE1 7RH Leicester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marie Adams (Mrs.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 504 297,20
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Tinglöv (Mr.)
UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
Italy
EU contribution
€ 407 996,60
Address
Piazza Umberto I 1
70121 Bari
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Francesca Vadacca (Dr.)
UNIVERSITE DE LAUSANNE
Switzerland
EU contribution
€ 540 631,52
Address
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Beatrice Desvergne (Prof.)
DEBRECENI EGYETEM
Hungary
EU contribution
€ 390 193,76
Address
Egyetem Ter 1
4032 Debrecen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Laszlo Nagy (Prof.)
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
France
EU contribution
€ 262 548,66
Address
Rue Laurent Fries 1
67404 Illkirch Graffenstaden
Activity type
Research Organisations
Administrative Contact
Steve Brooks (Dr.)
UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 247 437,96
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sergio Longo (Mr.)
DIAGENODE
Belgium
EU contribution
€ 205 260
Address
Rue Du Bois Saint Jean 3 Liege Park Science
4102 Seraing
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Helene Pendeville (Dr.)
UD-GENOMED MEDICAL GENOMIC TECHNOLOGIES KUTATAS-FEJLESZTESI ES SZOLGALTATO KFT
Hungary
EU contribution
€ 173 822,88
Address
Nagyerdei Krt 98
4032 Debrecen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gabor Zahuczky (Dr.)