Objective The INDOX proposal on industrial oxidoreductases aims to provide relevant industrial case stories to demonstrate the efficacy of optimized biocatalysts on targeted reactions, and to establish the processes scalability, sustainability and cost-efficiency versus chemical conversion processes. The chemical industry (specialties excluded) is not yet embracing enzymatic oxidation reactions to a significant extent primarily due to lack of biocatalysts with the required selectivity, availability and compatibility with the rigorous process conditions. Selected industrial oxidation and oxyfunctionalization target reactions form the basis for the INDOX screening and optimization of new biocatalysts, including: i) Intermediates for agrochemicals/APIs; ii) Polymer precursors and functionalized polymers; and iii) Intermediates for dye-stuffs. The project flow comprises: i) Recovery of selective biocatalysts from the groups of heme-peroxidases/peroxygenases, flavo-oxidases and copper-oxidoreductases from fungal genomes and other sources; ii) Improvement of their oxidative activity and stability by protein engineering (using rational design, directed evolution and hybrid approaches combined with computational calculations) to fulfill the operational and catalytic conditions required by the chemical industry; and iii) Optimization of reaction conditions and reactor configurations (including immobilization technologies and new enzymatic cascade reactions). Finally the cost efficiency compared to chemical processing will be evaluated. The INDOX approach is supported by a highly-specialized consortium of SMEs, large companies and research/academic institutions. Production of the new optimized biocatalysts and their introduction into the chemical market will take advantage from the participation of the world-leading company in the sector of industrial enzymes, together with several chemical companies willing to implement the new medium- and large-scale biotransformation processes. Fields of science natural scienceschemical scienceselectrochemistryelectrolysisnatural scienceschemical sciencespolymer sciencesnatural scienceschemical sciencescatalysisbiocatalysisnatural sciencesbiological sciencesgeneticsgenomesnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) FP7-KBBE - Specific Programme "Cooperation": Food, Agriculture and Biotechnology Topic(s) KBBE.2013.3.3-04 - Optimal and cost-effective industrial biocatalysts Call for proposal FP7-KBBE-2013-7-single-stage See other projects for this call Funding Scheme CP-TP - Collaborative Project targeted to a special group (such as SMEs) Coordinator AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Address Calle serrano 117 28006 Madrid Spain See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact María ángeles López Vázquez (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 2 097 078,00 Participants (15) Sort alphabetically Sort by EU Contribution Expand all Collapse all NOVOZYMES A/S Denmark EU contribution € 545 921,00 Address Krogshoejvej 36 2880 Bagsvaerd See on map Region Danmark Hovedstaden Københavns omegn Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Henrik Lund (Dr.) Links Contact the organisation Opens in new window Website Opens in new window TECHNISCHE UNIVERSITAET DRESDEN Germany EU contribution € 590 700,00 Address Helmholtzstrasse 10 01069 Dresden See on map Region Sachsen Dresden Dresden, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Sven Kreigenfeld (Mr.) Links Contact the organisation Opens in new window Website Opens in new window JENABIOS GMBH Germany EU contribution € 348 600,00 Address Lobstedter strasse 80 07749 Jena See on map Region Thüringen Thüringen Jena, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Katrin Scheibner (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II Italy EU contribution € 333 600,00 Address Corso umberto i, 40 80138 Napoli See on map Region Sud Campania Napoli Activity type Higher or Secondary Education Establishments Administrative Contact Giovanni Sannia (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Setas Kimya Sanayi AS Türkiye EU contribution € 333 265,00 Address Karanfil sok 1.levent 18 34330 Istanbul See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Rezzan Karaaslan (Dr.) Links Contact the organisation Opens in new window Website Opens in new window WAGENINGEN UNIVERSITY Netherlands EU contribution € 589 934,00 Address Droevendaalsesteeg 4 6708 PB Wageningen See on map Region Oost-Nederland Gelderland Veluwe Activity type Higher or Secondary Education Establishments Administrative Contact Tom Bessems (Mr.) Links Contact the organisation Opens in new window Website Opens in new window ANAXOMICS BIOTECH SL Spain EU contribution € 349 200,00 Address Calle diputacio 237, p 1 pta 1 08007 Barcelona See on map Region Este Cataluña Barcelona Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Vesna Radovanovic (Ms.) Links Contact the organisation Opens in new window Website Opens in new window CHIRACON GMBH Germany EU contribution € 319 000,00 Address Biotechnologiepark tgz 1 14943 Luckenwalde See on map Region Brandenburg Brandenburg Teltow-Fläming Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ralf Zuhse (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITAET FUER BODENKULTUR WIEN Austria EU contribution € 481 582,00 Address Gregor mendel strasse 33 1180 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Administrative Contact Roland Ludwig (Dr.) Links Contact the organisation Opens in new window Website Opens in new window TECHNISCHE UNIVERSITEIT DELFT Netherlands EU contribution € 592 075,00 Address Stevinweg 1 2628 CN Delft See on map Region West-Nederland Zuid-Holland Delft en Westland Activity type Higher or Secondary Education Establishments Administrative Contact Frank Hollmann (Dr.) Links Contact the organisation Opens in new window Website Opens in new window INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT France EU contribution € 525 662,70 Address 147 rue de l'universite 75007 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Sylvie Modeste (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window BIOPOLIS SL Spain EU contribution € 407 404,00 Address Calle catedratico agustin escardino benlloch 9 parque cientifico de la universidad de valencia 46980 Paterna valencia See on map Region Este Comunitat Valenciana Valencia/València Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Marta Tortajada (Dr.) Links Contact the organisation Opens in new window Website Opens in new window CHEMINOVA AS Participation ended Denmark EU contribution € 31 086,30 Address Harboorevej 78 7673 Harboore See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ib Winckelmann (Mr.) Links Contact the organisation Opens in new window Website Opens in new window CLEA TECHNOLOGIES BV Netherlands EU contribution € 250 536,00 Address Delftechpark 34 2628 XH Delft See on map Region West-Nederland Zuid-Holland Delft en Westland Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ivo Van Der Laan (Mr.) Links Contact the organisation Opens in new window Website Opens in new window RHODIA OPERATIONS France EU contribution € 30 180,00 Address 9 rue des cuirassiers, immeuble silex 2 solvay 69003 Lyon See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Talia Brun Links Contact the organisation Opens in new window Website Opens in new window
