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NanoBioEngineering of BioInspired BioPolymers

Objective

The Nano3Bio project convenes a consortium of world renowned experts from 8 EU universities, 1 large company, and 14 SME, to develop biotechnological production systems for nanoformulated chitosans. Chitosans, chitin-derived polysaccharides varying in their degree of polymerisation (DP), degree of acetylation (DA), and pattern of acetylation (PA), are among the most versatile and most promising biopolymers, with excellent physico-chemical and material properties, and a wide range of biological functionalities, but their economic potential is far from being exploited due to i) problems with reproducibility of biological activities as today’s chitosans are rather poorly defined mixtures, and ii) the threat of allergen contamination from their typical animal origin. The Nano3Bio project will overcome these hurdles to market entry and penetration by producing in vitro and in vivo defined oligo- and polymers with controlled, tailor-made DP, DA, and PA. Genes for chitin synthases, chitin deacetylases, and transglycosylating chitinases/chitosanases will be mined from different (meta)genomic sources and heterologously expressed, the recombinant enzymes characterized and optimized by protein engineering through rational design and molecular evolution, e.g. targeting engineered glycosynthases. These enzymes and genes will be used for in vitro and in vivo biosynthesis in microbial and microalgal systems, focusing on bacteria and diatoms. The bioinspired chitosans will be formulated into biomineralised hydrogels, nanoparticles, nanoscaffolds, etc., to impart novel properties, including by surface nano-imprinting, and will be bench-marked against their conventional counterparts in a variety of cell based assays and routine industrial tests for e.g. cosmetics and pharma markets. The process will be accompanied by comprehensive life cycle assessments including thorough legal landscaping, and by dissemination activities targeted to the scientific community and the general public.

Call for proposal

FP7-KBBE-2013-7-single-stage
See other projects for this call

Coordinator

Westfälische Wilhelms-Universität Münster
Address
Schlossplatz 2
48149 Muenster
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 654 200
Administrative Contact
Bruno Moerschbacher (Prof.)

Participants (21)

UNIVERSITEIT GENT
Belgium
EU contribution
€ 1 280 150
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Evelien Vandevelde (Ms.)
INSTITUT QUIMIC DE SARRIA
Spain
EU contribution
€ 480 938
Address
Calle Via Augusta 384-394
08017 Barcelona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joedmi Pereira (Dr.)
KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden
EU contribution
€ 783 810
Address
Brinellvagen 8
100 44 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marianne Fridborn (Mrs.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 389 480
Address
Rue Michel Ange 3
75794 Paris
Activity type
Other
Administrative Contact
Louis Avigdor (Mr.)
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 491 111
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ioannis S. Chronakis (Prof.)
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany
EU contribution
€ 410 539
Address
Seminarstrasse 2
69117 Heidelberg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stefan Schneider (Prof.)
UNIVERSITY OF HYDERABAD
India
EU contribution
€ 139 600
Address
Central University P.o Gachibowli
500046 Hyderabad
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Appa Rao Podile (Prof.)
GENEART AG
Germany
EU contribution
€ 373 200
Address
Josef-engert-strasse 9
93053 Regensburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Liss (Dr.)
GILLET CHITOSAN EURL
France
EU contribution
€ 137 040
Address
Laurent Bonnevay 17
54100 Nancy
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Dominique Gillet (Dr.)
COSPHATEC GMBH
Germany
EU contribution
€ 200 824
Address
Drehbahn 7
20354 Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Felipe Mahling (Mr.)
BIO BASE EUROPE PILOT PLANT VZW
Belgium
EU contribution
€ 377 600
Address
Rodenhuizekaai 1
9042 Desteldonk Gent
Activity type
Other
Administrative Contact
Lieve Hoflack (Dr.)
GREENALTECH SL
Spain
EU contribution
€ 435 600
Address
Calle Baldiri Reixac 4-10
08028 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Olga Durany (Dr.)
GREENDELTA GMBH
Germany
EU contribution
€ 87 120
Address
Kaiserdamm 13
14059 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Andreas Ciroth (Dr.)
2.-O LCA CONSULTANTS APS
Denmark
EU contribution
€ 114 580
Address
Rendsburggarde 14 4 315B
9000 Aalborg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Randi Lundshoej Dalgaard (Dr.)
ARTES BIOTECHNOLOGY GmbH
Germany
EU contribution
€ 202 368
Address
Elisabeth-selbert-str. 9
40764 Langenfeld
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Melanie Piontek (Dr.)
LYON INGENIERIE PROJETS
France
EU contribution
€ 384 000
Address
Bd Du 11 Novembre 1918 43 L Atrium
69616 Villeurbanne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Javier Olaiz (Dr.)
PETRA TEWES-SCHWARZER - CARE SENSE CONSULTING
Germany
EU contribution
€ 76 100
Address
Merschwiese 2A
48308 Senden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Petra Tewes-Schwarzer (Mrs.)
BEEMO GmbH
Germany
EU contribution
€ 399 220
Address
Soester Strasse 13
48155 Muenster
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gernot Bauer (Prof.)
HEPPE MEDICAL CHITOSAN GMBH
Germany
EU contribution
€ 213 644
Address
Heinrich Damerow Strasse 1
06120 Halle
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Katja Richter (Mrs.)
ENANTIA SL
Spain
EU contribution
€ 282 600
Address
Calle Baldiri Reixac 10
08028 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Carme Cantos (Dr.)
PERSEUS BVBA
Belgium
EU contribution
€ 75 600
Address
Technologiepark 4
9052 Zwijnaarde
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Patrick Rüdelsheim (Dr.)