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Proof Of Concept Use of MTH1 Inhibitors as New Treatments for cancer

Objective

"In our ERC grant GEnetic NEtworks as a tool for anti-CAncer Drug Development we used phenotypic screening and genetic networks to identify the DNA repair protein MTH1 as a critical component for cancer cell survival and we developed selective sub nM inhibitors to MTH1, which specifically kill cancer cells and tumours, whilst being less toxic to primary cells. Our approach provides a novel concept for treating cancer. Here, we want to explore the commercial potential of the MTH1 inhibitors identified in the ERC grant."

Field of science

  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

ERC-2013-PoC
See other projects for this call

Funding Scheme

CSA-SA(POC) - Supporting action (Proof of Concept)

Host institution

KAROLINSKA INSTITUTET
Address
Nobels Vag 5
17177 Stockholm
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 105 990
Administrative Contact
Jill Blomstrand (Mrs.)

Beneficiaries (2)

KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 105 990
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jill Blomstrand (Mrs.)
KAROLINSKA INSTITUTET INNOVATIONS AB
Sweden
EU contribution
€ 44 010
Address
Nanna Svartz Vag 6A
171 65 Solna
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Christian Krog-Jensen (Dr.)