Proof Of Concept Use of MTH1 Inhibitors as New Treatments for cancer

Objective

"In our ERC grant GEnetic NEtworks as a tool for anti-CAncer Drug Development we used phenotypic screening and genetic networks to identify the DNA repair protein MTH1 as a critical component for cancer cell survival and we developed selective sub nM inhibitors to MTH1, which specifically kill cancer cells and tumours, whilst being less toxic to primary cells. Our approach provides a novel concept for treating cancer. Here, we want to explore the commercial potential of the MTH1 inhibitors identified in the ERC grant."

Fields of science

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• natural sciences › biological sciences › genetics › DNA
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• medical and health sciences › clinical medicine › oncology

Programme(s)

• FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Topic(s)

• ERC-OA-2013-PoC - European Research Council ERC Proof of Concept

Call for proposal

ERC-2013-PoC
See other projects for this call

Funding Scheme

CSA-SA(POC) - Supporting action (Proof of Concept)

Host institution

KAROLINSKA INSTITUTET

Address

Nobels Vag 5
17177 Stockholm
Sweden

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Jill Blomstrand (Mrs.)

Links

EU contribution

€ 105 990

Beneficiaries (2)

KAROLINSKA INSTITUTET

Sweden

EU contribution

€ 105 990

Address

Nobels Vag 5
17177 Stockholm

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Jill Blomstrand (Mrs.)

Links

KAROLINSKA INSTITUTET INNOVATIONS AB

Sweden

EU contribution

€ 44 010

Address

Nanna Svartz Vag 6a
171 65 Solna

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Administrative Contact

Christian Krog-Jensen (Dr.)

Links