Proof Of Concept Use of MTH1 Inhibitors as New Treatments for cancer

Información del proyecto

POCUMINT

Identificador del acuerdo de subvención: 620297

Proyecto cerrado

Fecha de inicio 1 Mayo 2014

Fecha de finalización 30 Abril 2015

Financiado con arreglo a

• Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Coste total € 164 795,60

Aportación de la UE € 150 000,00

Coordinado por

KAROLINSKA INSTITUTET
Sweden

Objetivo

"In our ERC grant GEnetic NEtworks as a tool for anti-CAncer Drug Development we used phenotypic screening and genetic networks to identify the DNA repair protein MTH1 as a critical component for cancer cell survival and we developed selective sub nM inhibitors to MTH1, which specifically kill cancer cells and tumours, whilst being less toxic to primary cells. Our approach provides a novel concept for treating cancer. Here, we want to explore the commercial potential of the MTH1 inhibitors identified in the ERC grant."

Ámbito científico

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• natural sciences › biological sciences › genetics › DNA
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• medical and health sciences › clinical medicine › oncology

Programa(s)

• FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Tema(s)

• ERC-OA-2013-PoC - European Research Council ERC Proof of Concept

Convocatoria de propuestas

ERC-2013-PoC
Consulte otros proyectos de esta convocatoria

Régimen de financiación

CSA-SA(POC) - Supporting action (Proof of Concept)

Institución de acogida

KAROLINSKA INSTITUTET

Contacto administrativo

Jill Blomstrand (Mrs.)

• Aportación de la UE: € 105 990,00
• Dirección: Nobels Vag 5 ; 17177 Stockholm ; Suecia
• Región: Östra Sverige › Stockholm › Stockholms län
• Tipo de actividad: Higher or Secondary Education Establishments
• Coste total: Sin datos

Beneficiarios (2)

KAROLINSKA INSTITUTET

Suecia

Contacto administrativo

Jill Blomstrand (Mrs.)

• Aportación de la UE: € 105 990,00
• Dirección: Nobels Vag 5 ; 17177 Stockholm
• Región: Östra Sverige › Stockholm › Stockholms län
• Tipo de actividad: Higher or Secondary Education Establishments
• Coste total: Sin datos

KAROLINSKA INSTITUTET INNOVATIONS AB

Suecia

Contacto administrativo

Christian Krog-Jensen (Dr.)

• Aportación de la UE: € 44 010,00
• Dirección: NANNA SVARTZ VAG 6A ; 171 65 Solna
• Región: Östra Sverige › Stockholm › Stockholms län
• Tipo de actividad: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Coste total: Sin datos