Objective Hypervalent iodine reagents allow transformations under very mild reaction conditions. They are not only environmentally friendly oxidizing agents used in a wide range of transformations, but can also serve in highly selective asymmetric transformations which can be easily achieved using these reagents. The development of novel asymmetric metal-free transformations will lead to novel and powerful stereoselective protocols. Such advancements are still very much sought after for many transformations in organic synthesis and will be used by the fine chemical and pharmaceutical industries. The challenge of developing new metal-free approaches with chiral hypervalent iodine reagents is considerable as efficient procedures of this type are still in their infancy. We will develop novel and efficient enantiomerically pure hypervalent reagents/catalysts for such reactions. Iodonium ylide chemistry and utilization of suitable chiral iodonium ylides will be developed for the metal-free carbene transfer from iodonium ylides to carbon – nitrogen double bonds. Along with the successful development and application in asymmetric transformations, we will focus on the continuous-flow synthesis of complex molecules in which iodine reagent oxidation is one of the key steps. Self-optimization of reaction conditions through incorporation of analytical methods will be pursued. Fields of science natural scienceschemical scienceselectrochemistryelectrolysisnatural scienceschemical sciencesinorganic chemistryhalogensnatural scienceschemical sciencescatalysis Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2013-IIF - Marie Curie Action: "International Incoming Fellowships" Call for proposal FP7-PEOPLE-2013-IIF See other projects for this call Funding Scheme MC-IIF - International Incoming Fellowships (IIF) Coordinator CARDIFF UNIVERSITY EU contribution € 309 235,20 Address NEWPORT ROAD 30 36 CF24 0DE Cardiff United Kingdom See on map Region Wales East Wales Cardiff and Vale of Glamorgan Activity type Higher or Secondary Education Establishments Administrative Contact Debbie Taylor (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data