Development of novel biomimetic engineered dental implants for periodontal ligament regeneration

Project Information

BEDIMPLANTS

Grant agreement ID: 622280

Project closed

Start date 1 May 2014

End date 30 April 2016

Funded under

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Total cost € 309 235,20

EU contribution € 309 235,20

Coordinated by

KING'S COLLEGE LONDON
United Kingdom

Objective

BEDimplants project represents an innovative concept in oral implantology based on a multidisciplinary approach in periodontal regenerative medicine and tissue engineering that has the potential to significantly influence the outcome of medical and dental therapies. The project aims to develop novel biomimetic engineered dental implants (BEDimplants) that self-promote the regeneration of periodontal ligament (PDL) and provide in a single implant therapy the adequate environment to promote specific cell lineages, such as primary human gingival fibroblast (hGF) and dental pulp stem cells (hDPSC), to integrate, differentiate and proliferate within an artificial biomimetic extracellular matrix (aECM). The utilization of natural products and biomolecules present in the native periodontal ECM such as collagen, hyaluronic acid and cell signaling molecules, BMPs and TGFbs, to be grafted onto titanium surfaces is presented as a promising approach to the development of novelty implantable devices that mimic the complexity of ECM which can be reabsorbed or degraded by the organism after their implantation. Furthermore, self-crosslinkable bioactive peptide sequences (RGD and DGEA) can be synthesized and chemically linked to those biomolecules tailoring their biofunctionality and providing a biomimetic three-dimensional aECM-g-Ti scaffold that can be implanted in the presence of the appropriate cell cocktail that fulfill all the requirements of PDL tissue engineering.

Fields of science

Not validated

• medical and health sciences › clinical medicine › odontology › dental implantology
• natural sciences › biological sciences › biochemistry › biomolecules
• medical and health sciences › medical biotechnology › tissue engineering
• medical and health sciences › medical biotechnology › cells technologies › stem cells
• medical and health sciences › medical biotechnology › implants

Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Topic(s)

• FP7-PEOPLE-2013-IEF - Marie-Curie Action: "Intra-European fellowships for career development"

Call for proposal

FP7-PEOPLE-2013-IEF
See other projects for this call

Funding Scheme

MC-IEF - Intra-European Fellowships (IEF)

Coordinator

KING'S COLLEGE LONDON

• EU contribution: € 309 235,20
• Address: STRAND ; WC2R 2LS London ; United Kingdom
• Region: London › Inner London — West › Camden and City of London
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Paul Labbett (Mr.)
• Total cost: No data