Final Report Summary - BEDIMPLANTS (Development of novel biomimetic engineered dental implants for periodontal ligament regeneration) Bioengineered dental implant for periodontal ligament regenerationThis is an innovative concept in oral implantology based on a multidisciplinary approach in periodontal regenerative medicine and tissue engineering, which has the potential to significantly affect medical and dental therapies. Whether the implants need a proper interfacial connection with alveolar bone to promote osseointegration and bone cells needs an extracellular matrix attached to the implant surface, current available metal implants lack in the mimicking of the correct milieu for cell interactions and functionality to speed up the natural bone regeneration around the implant and provide a predictable regeneration of lost periodontal structures.This research has permit to graft a biomimetic extracellular matrix onto titanium implant surfaces that can be implanted in the presence of the appropriate cell cocktail resulting in a complete and predictable regeneration of hard (bone) and soft (periodontal ligament) tissues. This new approach represents a formidable challenge due to the fact of bone regeneration is largely dependent upon the proper interfacial connection of this multi-tissue complex and the availability of inductive and differentiation factors that determine its function and stability in health. Moreover, our research can be also translated to other metal based implant therapies such as craneofacial plates, fixation screws and hip replacement implants, among others. Our biomimetic implants have been designed to provide bioactive surface made by grafted bioactive self-assembled monolayers of currently used osteoinductive drugs and biomimetic extracellular matrix based on natural body existing cell signaling molecules and polysaccharides.Thus, this surface modification has permit to provide in a single therapy the adequate environment to promote the capacity of stem cells to integrate, differentiate and proliferate within a three-dimensional biohybrid milieu that mimic the proper interfacial connection of the multi-tissue triad of implant- PDL-alveolar bone. Moreover the methodology proposed avoid the use of harmful solvents or chemicals and thus can be can be easily scaled up leading to high interesting developments in a field of high social and economic impact with a high potential to impact in the industry. Documents connexes final1-publishable-summary-final.pdf
