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Radiation Response Models for Personalised Radiation Oncology

Objective

Clinical radiotherapy for cancer has seen dramatic improvements in recent years, driven by developments in imaging and delivery techniques. However, the ability to deliver radiation is now out-stripping radiotherapy planning techniques. Despite the goal of radiotherapy – tumour control – being primarily biological, radiotherapy planning tools focus on a purely physical metric: dose. This has significantly hampered the translation of knowledge gained from laboratory radiobiology to clinical settings. This project will lay the foundation for a unified model of therapeutic in vivo radiation responses by developing a computational model to describe these systems in a bottom-up fashion, integrating not only macroscopic parameters such as tumour size and dose, but also microscopic parameters such as radiation track structure and the cellular micro-environment.
As part of this project, collaboration will be developed between the radiation biology group in the Centre for Cancer Research and Cell Biology, Queen's University Belfast, and Massachusetts General Hospital. The applicant will take advantage of time spent in MGH to gain skills and experience in the delivery of proton therapy, broadening his technical background and placing him in a strong position to contribute to the development of this increasingly important treatment modality upon his return to the EU.
These models will enable a more natural integration of physical and biological parameters into radiation response models, facilitating improved knowledge transfer from laboratory to clinical practice. Through this, they can be used to address outstanding questions in modern radiotherapy, such as identifying the optimum dose distribution and delivery schedule for individual patients, and understanding the differences in biological responses to different types of radiation.

Call for proposal

FP7-PEOPLE-2013-IOF
See other projects for this call

Coordinator

THE QUEEN'S UNIVERSITY OF BELFAST
Address
University Road Lanyon Building
BT7 1NN Belfast
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 294 219,60
Administrative Contact
Aveen Lavery (Ms.)