Objective
Our genetic material is constantly exposed to mutagenic factors. DNA double-strand breaks (DSBs) represent one of the most dangerous forms of DNA damage and cells utilise two major pathways for their repair: error-prone non-homologous end-joining (NHEJ) and error-free homologous recombination (HR). The breast cancer susceptibility protein BRCA2 is a central player in HR that cooperates with its partner PALB2 in promoting the recruitment of RAD51 recombinase to the site of DNA damage. BRCA2 function is essential for the maintenance of genome integrity and mutations in the BRCA2 gene have been linked to breast and ovarian cancer, and to the cancer-prone syndrome Fanconi anemia.
To obtain new insights into how various aspects of homology-directed repair are coordinated by BRCA2 and its cofactors I intend to:
1. Characterize the structural properties of BRCA2 together with its partners RAD51 and PALB2, in order to identify important interaction regions.
2. Define the functional relevance of these interaction sites using a combination of biochemical and in vivo techniques to uncover the molecular mechanism of BRCA2-mediated DNA repair and to address the specific roles of its partner proteins RAD51 and PALB2.
The results will be important for understanding the molecular basis of BRCA2-associated pathogenesis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology breast cancer
- natural sciences biological sciences genetics mutation
- medical and health sciences clinical medicine hematology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
E20 1JQ LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.