Objectif Drug delivery transport across the cell membrane involves many biological processes. It is complex and dynamic in nature. In this regard, model lipid membranes which mimic many aspects of cell membrane lipids, are a very useful membrane model. It has been shown that physical characteristics of drug delivery nanoparticles such as polarity and surface charge can significantly influence their interactions with lipids. A clear understanding of the interactions of lipids with drug delivery systems and their transport mechanisms is required to enable the design of an efficient and biologically compatible drug delivery vehicle.The aim of this project is to focus on the physico-chemical understanding of the relationships between the structure of the nanoparticles and their penetration and efficiency as a drug delivery vehicle. In this research, we wish to clarify the mechanisms involved in the interactions between nanogels and dermal membranes and find out how these are influenced by physico-chemical conditions and the morphology of the nanogels. The outcome of this research would aid the design of the next generation of dermal delivery systems and also contribute to the risk assessment of skin exposure to nanoparticles.The scientific challenges to be investigated in this project will focus on the understanding of the molecular mechanisms of interaction between organic nanomaterials and biological barriers, in particular skin. The project will benefit from the combination of high level experimental facilities available in the Host Institute and the longstanding expertise of the group in the development of novel functional nanomaterials for drug delivery applications as well as experience in the area of understanding the biological processes and potential drug targets (by means of e.g. neutron scattering and reflectivity) with the knowledge and experience acquired by the applicant on nanoparticle synthesis, their physico-chemical characterization and interactions. Champ scientifique natural sciencesbiological sciencesbiochemistrybiomoleculeslipidsengineering and technologynanotechnologynano-materials Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2013-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Appel à propositions FP7-PEOPLE-2013-IEF Voir d’autres projets de cet appel Régime de financement MC-IEF - Intra-European Fellowships (IEF) Coordinateur QUEEN MARY UNIVERSITY OF LONDON Contribution de l’UE € 231 283,20 Adresse 327 MILE END ROAD E1 4NS London Royaume-Uni Voir sur la carte Région London Inner London — East Tower Hamlets Type d’activité Higher or Secondary Education Establishments Contact administratif Marina Resmini (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée