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VTA-specific noradrenergic regulation of motivational control

Objective

"Motivational control is crucial for adaptive behaviors. Conversely, disruption of motivational control leads to maladaptive behaviors and is one of the core symptoms of addiction. Noradrenaline (NA) system, encompassing NA neurons in locus coeruleus and nucleus tractus solitiarius is well positioned to regulate motivational control; however its exact contribution is not fully understood. Here we aim to evaluate the role of NA system activity in the ventral tegmental area (VTA) in motivational control in both opiate-naive and opiate-exposed mice. Using behavioral model of motivational control in combination with real-time, dynamic optical stimulation of NA neurons terminals in the VTA we plan to provide unprecedented data on NA mechanisms of motivational control and identify specific brain locus within the NA system responsible for specific type of motivational control. In addition, proposed project aims at transfering optogenetics ""know how"" to the host Institution."

Call for proposal

FP7-PEOPLE-2013-IIF
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Funding Scheme

MC-IIF - International Incoming Fellowships (IIF)
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Coordinator

INSTYTUT FARMAKOLOGII POLSKIEJ AKADEMII NAUK
Address
Smetna 12
31-343 Krakow
Poland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 140 863,80
Administrative Contact
Ryszard Przewlocki (Prof.)