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Contenuto archiviato il 2024-05-29

VTA-specific noradrenergic regulation of motivational control

Obiettivo

"Motivational control is crucial for adaptive behaviors. Conversely, disruption of motivational control leads to maladaptive behaviors and is one of the core symptoms of addiction. Noradrenaline (NA) system, encompassing NA neurons in locus coeruleus and nucleus tractus solitiarius is well positioned to regulate motivational control; however its exact contribution is not fully understood. Here we aim to evaluate the role of NA system activity in the ventral tegmental area (VTA) in motivational control in both opiate-naive and opiate-exposed mice. Using behavioral model of motivational control in combination with real-time, dynamic optical stimulation of NA neurons terminals in the VTA we plan to provide unprecedented data on NA mechanisms of motivational control and identify specific brain locus within the NA system responsible for specific type of motivational control. In addition, proposed project aims at transfering optogenetics ""know how"" to the host Institution."

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Argomento(i)

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FP7-PEOPLE-2013-IIF
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Meccanismo di finanziamento

MC-IIF - International Incoming Fellowships (IIF)

Coordinatore

INSTYTUT FARMAKOLOGII IM. JERZEGO MAJA POLSKIEJ AKADEMII NAUK
Contributo UE
€ 140 863,80
Indirizzo
UL. SMETNA 12
31 343 KRAKOW
Polonia
Regione
Makroregion województwo mazowieckie Warszawski stołeczny Miasto Warszawa
Tipo di attività
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Collegamenti
Costo totale
Nessun dato