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EuroMix

Objective

Euromix aim to develop an experimentally verified, tiered strategy for the risk assessment of mixtures of multiple chemicals derived from multiple sources across different life stages. The project takes account of the gender dimension and balances the risk of chemicals present in foods against the benefits of those foods.
Important concepts for this new strategy are prioritisation criteria for chemicals based on their exposure and hazard characteristics and evaluation of the role of mode of action in grouping chemicals into cumulative assessment groups. In-silico and in-vitro tools will be developed and verified against in-vivo experiments, with focus on four selected endpoints (liver, hormones, development and immunology) to provide a full proof-of-principle. The EuroMix project will result in an innovative platform of bioassays for mixture testing and refined categorisation of chemicals in cumulative assessment groups.
New hazard and exposure models will be embedded in a model toolbox, made available for stakeholders through an openly accessible web-based platform. Access to the web-based tools will be facilitated by training. Criteria will be set and guidance will be written on how to use and implement the tiered test strategy. Dissemination and harmonisation of the approach within EU, Codex Alimentarius, and WHO will be achieved by involving a.o. WHO and US-EPA in the project and by the participation of experts playing a key role in helping establish international food safety policies.
It is expected that the new mechanism-based strategy, the bioassay platform, the openly accessible web-based model toolbox, and clear guidance on a tiered hazard and exposure test and risk assessment strategy will boost innovation in the public and private sector, provide a sound scientific basis for managing risks to public health from chemical mixtures, ultimately reduce the use of laboratory animals, and support the global discussion of risk assessment policies for mixtures.

Field of science

  • /medical and health sciences/health sciences/public and environmental health
  • /medical and health sciences/basic medicine/immunology
  • /engineering and technology/other engineering and technologies/food and beverages/food safety

Call for proposal

H2020-SFS-2014-2
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Address
Antonie Van Leeuwenhoeklaan 9
3721 MA Bilthoven
Netherlands
Activity type
Research Organisations
EU contribution
€ 1 024 699,68

Participants (22)

STICHTING WAGENINGEN RESEARCH
Netherlands
EU contribution
€ 1 186 874
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Research Organisations
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 297 500
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
AGENCE NATIONALE DE LA SECURITE SANITAIRE DE L ALIMENTATION DE L ENVIRONNEMENT ET DU TRAVAIL
France
EU contribution
€ 449 286
Address
14 Rue Pierre Et Marie Curie
94700 Maisons Alfort
Activity type
Research Organisations
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
EU contribution
€ 348 341
Address
Rue De L'universite 147
75338 Paris Cedex 07
Activity type
Research Organisations
INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS
France
EU contribution
€ 298 144
Address
Parc Technologique Alata
60550 Verneuil En Halatte
Activity type
Research Organisations
UNIVERSITEIT GENT
Belgium
EU contribution
€ 348 958
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
EUROPEAN FRESH PRODUCE ASSOCIATION AISBL
Belgium
EU contribution
€ 48 750
Address
Rue De Treves 49-51
1040 Bruxelles
Activity type
Other
BUNDESINSTITUT FUER RISIKOBEWERTUNG
Germany
EU contribution
€ 797 875
Address
Max Dohrn Strasse 8-10
10589 Berlin
Activity type
Research Organisations
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 484 702
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
MATIS OHF
Iceland
EU contribution
€ 313 681
Address
Vinlandsleid 12
113 Reykjavik
Activity type
Research Organisations
Ministry of Health of the Republic of Cyprus
Cyprus
EU contribution
€ 50 000
Address
1 Prodromou Street & 17 Chilonos Street 1 & 17
1448 Nicosia
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
NACIONALNI INSTITUT ZA JAVNO ZDRAVJE
Slovenia
EU contribution
€ 50 313
Address
Trubarjeva Cesta 2
1000 Ljubljana
Activity type
Research Organisations
STATNI ZDRAVOTNI USTAV
Czechia
EU contribution
€ 75 093
Address
Srobarova 48
10042 Praha 10
Activity type
Research Organisations
FOLKEHELSEINSTITUTTET
Norway
EU contribution
€ 497 738
Address
Lovisenberggata 8
0456 Oslo
Activity type
Research Organisations
UNIVERSITAT ROVIRA I VIRGILI
Spain
EU contribution
€ 425 720
Address
Carrer De Escorxador
43003 Tarragona
Activity type
Higher or Secondary Education Establishments
BENAKI PHYTOPATHOLOGICAL INSTITUTE
Greece
EU contribution
€ 249 633
Address
Stefanou Delta Street 8
14561 Athina
Activity type
Research Organisations
UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 592 538,81
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 74 982
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
HEALTH AND SAFETY EXECUTIVE
United Kingdom
EU contribution
€ 13 229,16
Address
Merton Road, Redgrave Court
L20 7HS Bootle Merseyside
Activity type
Research Organisations
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 0
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS

Participation ended

United Kingdom
EU contribution
€ 0
Address
Area 1A, Nobel House, Smith Square 17
SW1P 3JR London
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
FERA SCIENCE LIMITED
United Kingdom
EU contribution
€ 371 039,35
Address
30 Berners Street
W1T 3LR London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)