Conservative iron chelation as a disease-modifying strategy in Parkinson’s disease: a multicentric, parallel-group, placebo-controlled, randomized clinical trial of deferiprone

Project Information

FAIR-PARK-II

Grant agreement ID: 633190

DOI 10.3030/633190

Project closed

EC signature date 14 April 2015

Start date 1 May 2015

End date 31 October 2021

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 8 263 202,50

EU contribution € 5 998 994,00

Coordinated by

CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE
France

Deliverables

Documents, reports (1)

Report on status of posting results in the study registry

Report on the status of the result posting including timelines when final posting of results is scheduled after end of funding period

Websites, patent fillings, videos etc. (1)

Communication and Dissemination tools including website

Graphic standards (M1), presentation leaflet and poster (M3), FAIR-PARK-II PowerPoint presentation (M3), provisional public website goes live (M1), FAIR-PARK-II website fully functional, including the secure area (M4), and a press release at the time of the kick-off meeting (M1)

Publications

Peer reviewed articles (13)

Data driven diagnostic classification in Alzheimer's disease based on different reference regions for normalization of PiB-PET images and correlation with CSF concentrations of Aβ species

Author(s): Francisco Oliveira, Antoine Leuzy, João Castelhano, Konstantinos Chiotis, Steen Gregers Hasselbalch, Juha Rinne, Alexandre Mendonça, Markus Otto, Alberto LleógIsabe, Santanah Jarkko Johansson, Sarah Anderl-Straub, Christine Arnim, Ambros Beer, Rafael Blesa, Juan Fortea, Herukka Sanna-Kaisa, Erik Porteliusl, Josef Panneel, Henrik Zetterberglmn, Kaj Blennowl, Ana P.Moreira, Antero Abrunhosa, Agne
Published in: NeuroImage: Clinical, Issue Volume 20, 2018, Page(s) 603-610, ISSN 2213-1582
Publisher: Elsevier BV
DOI: 10.1016/j.nicl.2018.08.023

Mobility Deficits Assessed With Mobile Technology: What Can We Learn From Brain Iron-Altered Animal Models?

Author(s): Franziska Hopfner, Markus A. Hobert, Corina Maetzler, Clint Hansen, Minh Hoang Pham, Caroline Moreau, Daniela Berg, David Devos, Walter Maetzler
Published in: Frontiers in Neurology, Issue 10, 2019, Page(s) article 833, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2019.00833

Ferroptosis and its potential role in the physiopathology of Parkinson’s Disease

Author(s): Laura Mahoney-Sánchez, Hind Bouchaoui, Scott Ayton, David Devos, James A. Duce, Jean-Christophe Devedjian
Published in: Progress in Neurobiology, Issue 196, 2021, Page(s) 101890, ISSN 0301-0082
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.pneurobio.2020.101890

Comparison of Internal Standard Approaches for SRM Analysis of Alpha-Synuclein in Cerebrospinal Fluid

Author(s): Patrick Oeckl, Petra Steinacker, and Markus Otto
Published in: Journal of Proteome Research, Issue 17(1), 2018, Page(s) 516-523, ISSN 1535-3893
Publisher: American Chemical Society
DOI: 10.1021/acs.jproteome.7b00660

Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia

Author(s): Anja Hviid Simonsena Sanna Kaisa Herukkab Niels AndreasencInesBaldeirasdMariaBjerkeeKajBlennowfSebastiaanEngelborghsegGiovanni B.Frisonihi, Tomasz Gabryelewiczj Samantha Galluzzi Ron Handelsk Milica G. Krambergerl Agnieszka Kulczyńskam Jose Luis Molinuevono Barbara Mroczkomp Agneta Nordbergq Catarina ResendeOliveirad Markus Otto, Juha O.RinnesUrošRotlEsenSakatHilkkaSoininenbHanneStruyfseSilviaSu
Published in: Alzheimer's & Dementia, Issue Volume 13, Issue 3, 2017, Page(s) 274-284, ISSN 1552-5260
Publisher: Elsevier BV
DOI: 10.1016/j.jalz.2016.09.008

Poly-GP in cerebrospinal fluid links C9orf72-associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD

Author(s): Carina Lehmer Patrick Oeckl Jochen H Weishaupt Alexander E Volk Janine Diehl-Schmid Matthias L Schroeter Martin Lauer Johannes Kornhuber Johannes Levin Klaus Fassbender Bernhard Landwehrmeyer German Consortium for Frontotemporal Lobar Degeneration Martin H Schludi Thomas Arzberger Elisabeth Kremmer Andrew Flatley Regina Feederle Petra Steinacker Patrick Weydt Albert C Ludolph Dieter Edbauer Markus
Published in: EMBO Molecular Medicine Journal, 2017, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201607486

Iron as a therapeutic target for Parkinson's disease

Author(s): Caroline Moreau, James A. Duce, Olivier Rascol, Jean-Christophe Devedjian, Daniela Berg, David Dexter, Z. Ioav Cabantchik, Ashley I. Bush, David Devos
Published in: Movement Disorders, Issue 33/4, 2018, Page(s) 568-574, ISSN 0885-3185
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mds.27275

Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration

Author(s): Shashank Masaldan, Ashley I. Bush, David Devos, Anne Sophie Rolland, Caroline Moreau
Published in: Free Radical Biology and Medicine, Issue 133, 2019, Page(s) 221-233, ISSN 0891-5849
Publisher: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2018.09.033

Bioavailable Trace Metals in Neurological Diseases

Author(s): Aurélia Poujois, Jean-Christophe Devedjian, Caroline Moreau, David Devos, Pascal Chaine, France Woimant, James A. Duce
Published in: Current Treatment Options in Neurology, Issue 18/10, 2016, ISSN 1092-8480
Publisher: Current Science Inc.
DOI: 10.1007/s11940-016-0426-1

Validation of a Lower Back “Wearable”-Based Sit-to-Stand and Stand-to-Sit Algorithm for Patients With Parkinson's Disease and Older Adults in a Home-Like Environment

Author(s): Minh H. Pham, Elke Warmerdam, Morad Elshehabi, Christian Schlenstedt, Lu-Marie Bergeest, Maren Heller, Linda Haertner, Joaquim J. Ferreira, Daniela Berg, Gerhard Schmidt, Clint Hansen, Walter Maetzler
Published in: Frontiers in Neurology, Issue 9, 2018, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2018.00652

Validation of a Step Detection Algorithm during Straight Walking and Turning in Patients with Parkinson’s Disease and Older Adults Using an Inertial Measurement Unit at the Lower Back

Author(s): Minh H. Pham, Morad Elshehabi, Linda Haertner, Silvia Del Din, Karin Srulijes, Tanja Heger, Matthis Synofzik, Markus A. Hobert, Gert S. Faber, Clint Hansen, Dina Salkovic, Joaquim J. Ferreira, Daniela Berg, Álvaro Sanchez-Ferro, Jaap H. van Dieën, Clemens Becker, Lynn Rochester, Gerhard Schmidt, Walter Maetzler
Published in: Frontiers in Neurology, Issue 8, 2017, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2017.00457

Development and Validation of an Ultrasensitive Procalcitonin Sandwich Immunoassay

Author(s): Viviana A. Carcamo Yañez, Jens C. Göpfert , Markus Otto, Hayrettin Tumani, Andreas Peter, Thomas O. Joos
Published in: High-Throughput, 2017, ISSN 2571-5135
Publisher: MDPI
DOI: 10.3390/ht6040018

Conservative iron chelation for neurodegenerative diseases such as Parkinson’s disease and amyotrophic lateral sclerosis

Author(s): David Devos, Z. Ioav Cabantchik, Caroline Moreau, Véronique Danel, Laura Mahoney-Sanchez, Hind Bouchaoui, Flore Gouel, Anne-Sophie Rolland, James A. Duce, Jean-Christophe Devedjian
Published in: Journal of Neural Transmission, Issue 127/2, 2020, Page(s) 189-203, ISSN 0300-9564
Publisher: Springer Verlag
DOI: 10.1007/s00702-019-02138-1