Conservative iron chelation as a disease-modifying strategy in Parkinson’s disease: a multicentric, parallel-group, placebo-controlled, randomized clinical trial of deferiprone

Informazioni relative al progetto

FAIR-PARK-II

ID dell’accordo di sovvenzione: 633190

DOI

10.3030/633190

Progetto chiuso

Data della firma CE 14 Aprile 2015

Data di avvio 1 Maggio 2015

Data di completamento 31 Ottobre 2021

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 8 263 202,50

Contributo UE

€ 5 998 994,00

Coordinato da

CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE
France

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (1)

Report on status of posting results in the study registry

Report on the status of the result posting including timelines when final posting of results is scheduled after end of funding period

Websites, patent fillings, videos etc. (1)

Communication and Dissemination tools including website

Graphic standards (M1), presentation leaflet and poster (M3), FAIR-PARK-II PowerPoint presentation (M3), provisional public website goes live (M1), FAIR-PARK-II website fully functional, including the secure area (M4), and a press release at the time of the kick-off meeting (M1)

Pubblicazioni

Peer reviewed articles (13)

Data driven diagnostic classification in Alzheimer's disease based on different reference regions for normalization of PiB-PET images and correlation with CSF concentrations of Aβ species

Autori: Francisco Oliveira, Antoine Leuzy, João Castelhano, Konstantinos Chiotis, Steen Gregers Hasselbalch, Juha Rinne, Alexandre Mendonça, Markus Otto, Alberto LleógIsabe, Santanah Jarkko Johansson, Sarah Anderl-Straub, Christine Arnim, Ambros Beer, Rafael Blesa, Juan Fortea, Herukka Sanna-Kaisa, Erik Porteliusl, Josef Panneel, Henrik Zetterberglmn, Kaj Blennowl, Ana P.Moreira, Antero Abrunhosa, Agne
Pubblicato in: NeuroImage: Clinical, Numero Volume 20, 2018, Pagina/e 603-610, ISSN 2213-1582
Editore: Elsevier BV
DOI: 10.1016/j.nicl.2018.08.023

Mobility Deficits Assessed With Mobile Technology: What Can We Learn From Brain Iron-Altered Animal Models?

Autori: Franziska Hopfner, Markus A. Hobert, Corina Maetzler, Clint Hansen, Minh Hoang Pham, Caroline Moreau, Daniela Berg, David Devos, Walter Maetzler
Pubblicato in: Frontiers in Neurology, Numero 10, 2019, Pagina/e article 833, ISSN 1664-2295
Editore: Frontiers Research Foundation
DOI: 10.3389/fneur.2019.00833

Ferroptosis and its potential role in the physiopathology of Parkinson’s Disease

Autori: Laura Mahoney-Sánchez, Hind Bouchaoui, Scott Ayton, David Devos, James A. Duce, Jean-Christophe Devedjian
Pubblicato in: Progress in Neurobiology, Numero 196, 2021, Pagina/e 101890, ISSN 0301-0082
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.pneurobio.2020.101890

Comparison of Internal Standard Approaches for SRM Analysis of Alpha-Synuclein in Cerebrospinal Fluid

Autori: Patrick Oeckl, Petra Steinacker, and Markus Otto
Pubblicato in: Journal of Proteome Research, Numero 17(1), 2018, Pagina/e 516-523, ISSN 1535-3893
Editore: American Chemical Society
DOI: 10.1021/acs.jproteome.7b00660

Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia

Autori: Anja Hviid Simonsena Sanna Kaisa Herukkab Niels AndreasencInesBaldeirasdMariaBjerkeeKajBlennowfSebastiaanEngelborghsegGiovanni B.Frisonihi, Tomasz Gabryelewiczj Samantha Galluzzi Ron Handelsk Milica G. Krambergerl Agnieszka Kulczyńskam Jose Luis Molinuevono Barbara Mroczkomp Agneta Nordbergq Catarina ResendeOliveirad Markus Otto, Juha O.RinnesUrošRotlEsenSakatHilkkaSoininenbHanneStruyfseSilviaSu
Pubblicato in: Alzheimer's & Dementia, Numero Volume 13, Numero 3, 2017, Pagina/e 274-284, ISSN 1552-5260
Editore: Elsevier BV
DOI: 10.1016/j.jalz.2016.09.008

Poly-GP in cerebrospinal fluid links C9orf72-associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD

Autori: Carina Lehmer Patrick Oeckl Jochen H Weishaupt Alexander E Volk Janine Diehl-Schmid Matthias L Schroeter Martin Lauer Johannes Kornhuber Johannes Levin Klaus Fassbender Bernhard Landwehrmeyer German Consortium for Frontotemporal Lobar Degeneration Martin H Schludi Thomas Arzberger Elisabeth Kremmer Andrew Flatley Regina Feederle Petra Steinacker Patrick Weydt Albert C Ludolph Dieter Edbauer Markus
Pubblicato in: EMBO Molecular Medicine Journal, 2017, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201607486

Iron as a therapeutic target for Parkinson's disease

Autori: Caroline Moreau, James A. Duce, Olivier Rascol, Jean-Christophe Devedjian, Daniela Berg, David Dexter, Z. Ioav Cabantchik, Ashley I. Bush, David Devos
Pubblicato in: Movement Disorders, Numero 33/4, 2018, Pagina/e 568-574, ISSN 0885-3185
Editore: John Wiley & Sons Inc.
DOI: 10.1002/mds.27275

Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration

Autori: Shashank Masaldan, Ashley I. Bush, David Devos, Anne Sophie Rolland, Caroline Moreau
Pubblicato in: Free Radical Biology and Medicine, Numero 133, 2019, Pagina/e 221-233, ISSN 0891-5849
Editore: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2018.09.033

Bioavailable Trace Metals in Neurological Diseases

Autori: Aurélia Poujois, Jean-Christophe Devedjian, Caroline Moreau, David Devos, Pascal Chaine, France Woimant, James A. Duce
Pubblicato in: Current Treatment Options in Neurology, Numero 18/10, 2016, ISSN 1092-8480
Editore: Current Science Inc.
DOI: 10.1007/s11940-016-0426-1

Validation of a Lower Back “Wearable”-Based Sit-to-Stand and Stand-to-Sit Algorithm for Patients With Parkinson's Disease and Older Adults in a Home-Like Environment

Autori: Minh H. Pham, Elke Warmerdam, Morad Elshehabi, Christian Schlenstedt, Lu-Marie Bergeest, Maren Heller, Linda Haertner, Joaquim J. Ferreira, Daniela Berg, Gerhard Schmidt, Clint Hansen, Walter Maetzler
Pubblicato in: Frontiers in Neurology, Numero 9, 2018, ISSN 1664-2295
Editore: Frontiers Research Foundation
DOI: 10.3389/fneur.2018.00652

Validation of a Step Detection Algorithm during Straight Walking and Turning in Patients with Parkinson’s Disease and Older Adults Using an Inertial Measurement Unit at the Lower Back

Autori: Minh H. Pham, Morad Elshehabi, Linda Haertner, Silvia Del Din, Karin Srulijes, Tanja Heger, Matthis Synofzik, Markus A. Hobert, Gert S. Faber, Clint Hansen, Dina Salkovic, Joaquim J. Ferreira, Daniela Berg, Álvaro Sanchez-Ferro, Jaap H. van Dieën, Clemens Becker, Lynn Rochester, Gerhard Schmidt, Walter Maetzler
Pubblicato in: Frontiers in Neurology, Numero 8, 2017, ISSN 1664-2295
Editore: Frontiers Research Foundation
DOI: 10.3389/fneur.2017.00457

Development and Validation of an Ultrasensitive Procalcitonin Sandwich Immunoassay

Autori: Viviana A. Carcamo Yañez, Jens C. Göpfert , Markus Otto, Hayrettin Tumani, Andreas Peter, Thomas O. Joos
Pubblicato in: High-Throughput, 2017, ISSN 2571-5135
Editore: MDPI
DOI: 10.3390/ht6040018

Conservative iron chelation for neurodegenerative diseases such as Parkinson’s disease and amyotrophic lateral sclerosis

Autori: David Devos, Z. Ioav Cabantchik, Caroline Moreau, Véronique Danel, Laura Mahoney-Sanchez, Hind Bouchaoui, Flore Gouel, Anne-Sophie Rolland, James A. Duce, Jean-Christophe Devedjian
Pubblicato in: Journal of Neural Transmission, Numero 127/2, 2020, Pagina/e 189-203, ISSN 0300-9564
Editore: Springer Verlag
DOI: 10.1007/s00702-019-02138-1