Efficacy and safety of low-dose IL-2 (ld-IL-2) as a Treg enhancer for anti-neuroinflammatory therapy in newly diagnosed Amyotrophic Lateral Sclerosis (ALS) patients

Deliverables

Documents, reports (1)

Approval from IRBs and Regulatory Agencies

All approval documents to start patient recruitment.

Demonstrators, pilots, prototypes (1)

Corporate communication tools provided

Logo, brochure, public website

Publications

Peer reviewed articles (13)

The genetics of amyotrophic lateral sclerosis: current insights

Author(s): Janine Kirby, Afnan Al Sultan, Rachel Waller, Paul Heath
Published in: Degenerative Neurological and Neuromuscular Disease, 2016, Page(s) 49, ISSN 1179-9900
DOI: 10.2147/dnnd.s84956

A comprehensive analysis of rare genetic variation in amyotrophic lateral sclerosis in the UK

Author(s): Sarah Morgan, Aleksey Shatunov, William Sproviero, Ashley R. Jones, Maryam Shoai, Deborah Hughes, Ahmad Al Khleifat, Andrea Malaspina, Karen E. Morrison, Pamela J. Shaw, Christopher E. Shaw, Katie Sidle, Richard W. Orrell, Pietro Fratta, John Hardy, Alan Pittman, Ammar Al-Chalabi
Published in: Brain, Issue 140/6, 2017, Page(s) 1611-1618, ISSN 0006-8950
DOI: 10.1093/brain/awx082

Genetic testing in ALS

Author(s): Alice Vajda, Russell L. McLaughlin, Mark Heverin, Owen Thorpe, Sharon Abrahams, Ammar Al-Chalabi, Orla Hardiman
Published in: Neurology, Issue 88/10, 2017, Page(s) 991-999, ISSN 0028-3878
DOI: 10.1212/WNL.0000000000003686

Detection of long repeat expansions from PCR-free whole-genome sequence data

Author(s): Egor Dolzhenko, Joke J.F.A. van Vugt, Richard J. Shaw, Mitchell A. Bekritsky, Marka van Blitterswijk, Giuseppe Narzisi, Subramanian S. Ajay, Vani Rajan, Bryan R. Lajoie, Nathan H. Johnson, Zoya Kingsbury, Sean J. Humphray, Raymond D. Schellevis, William J. Brands, Matt Baker, Rosa Rademakers, Maarten Kooyman, Gijs H.P. Tazelaar, Michael A. van Es, Russell McLaughlin, William Sproviero, Aleksey Sha
Published in: Genome Research, Issue 27/11, 2017, Page(s) 1895-1903, ISSN 1088-9051
DOI: 10.1101/gr.225672.117

Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging study

Author(s): Ton Fang, Ahmad Al Khleifat, Jacques-Henri Meurgey, Ashley Jones, P Nigel Leigh, Gilbert Bensimon, Ammar Al-Chalabi
Published in: The Lancet Neurology, Issue 17/5, 2018, Page(s) 416-422, ISSN 1474-4422
DOI: 10.1016/S1474-4422(18)30054-1

Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases

Author(s): Jason A. Chen, Zhongbo Chen, Hyejung Won, Alden Y. Huang, Jennifer K. Lowe, Kevin Wojta, Jennifer S. Yokoyama, Gilbert Bensimon, P. Nigel Leigh, Christine Payan, Aleksey Shatunov, Ashley R. Jones, Cathryn M. Lewis, Panagiotis Deloukas, Philippe Amouyel, Christophe Tzourio, Jean-Francois Dartigues, Albert Ludolph, Adam L. Boxer, Jeff M. Bronstein, Ammar Al-Chalabi, Daniel H. Geschwind, Giovanni Cop
Published in: Molecular Neurodegeneration, Issue 13/1, 2018, ISSN 1750-1326
DOI: 10.1186/s13024-018-0270-8

The benefit of evolving multidisciplinary care in ALS: a diagnostic cohort survival comparison

Author(s): Sarah Martin, Emma Trevor-Jones, Sabyha Khan, Keelan Shaw, Deepti Marchment, Anna Kulka, Catherine E Ellis, Rachel Burman, Martin R. Turner, Liam Carroll, Leah Mursaleen, P. Nigel Leigh, Christopher E. Shaw, Neil Pearce, Daniel Stahl, Ammar Al-Chalabi
Published in: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Issue 18/7-8, 2017, Page(s) 569-575, ISSN 2167-8421
DOI: 10.1080/21678421.2017.1349151

Proposed association between the hexanucleotide repeat of C9orf72 and opposability index of the thumb

Author(s): Zhongbo Chen, Kuang Lin, Jeffrey D. Macklis, Ammar Al-Chalabi
Published in: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Issue 18/3-4, 2017, Page(s) 175-181, ISSN 2167-8421
DOI: 10.1080/21678421.2016.1257024

ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function

Author(s): Martina de Majo, Simon D. Topp, Bradley N. Smith, Agnes L. Nishimura, Han-Jou Chen, Athina Soragia Gkazi, Jack Miller, Chun Hao Wong, Caroline Vance, Frank Baas, Anneloor L.M.A. ten Asbroek, Kevin P. Kenna, Nicola Ticozzi, Alberto Garcia Redondo, Jesús Esteban-Pérez, Cinzia Tiloca, Federico Verde, Stefano Duga, Karen E. Morrison, Pamela J. Shaw, Janine Kirby, Martin R. Turner, Kevin Talbot, Orla
Published in: Neurobiology of Aging, Issue 71, 2018, Page(s) 266.e1-266.e10, ISSN 0197-4580
DOI: 10.1016/j.neurobiolaging.2018.06.015

Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis

Author(s): Jeremy A. Garson, Louise Usher, Ammar Al-Chalabi, Jim Huggett, Edmund F. Day, Adele L. McCormick
Published in: Acta Neuropathologica Communications, Issue 7/1, 2019, ISSN 2051-5960
DOI: 10.1186/s40478-019-0698-2

Telomere length is greater in ALS than in controls: a whole genome sequencing study

Author(s): Ahmad Al Khleifat, Alfredo Iacoangeli, Aleksey Shatunov, Ton Fang, William Sproviero, Ashley R. Jones, Sarah Opie-Martin, Karen E. Morrison, Pamela J. Shaw, Christopher E. Shaw, John F. Powell, Richard Dobson, Steven J. Newhouse, Ammar Al-Chalabi
Published in: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Issue 20/3-4, 2019, Page(s) 229-234, ISSN 2167-8421
DOI: 10.1080/21678421.2019.1586951

DNAscan: personal computer compatible NGS analysis, annotation and visualisation

Author(s): A. Iacoangeli, A. Al Khleifat, W. Sproviero, A. Shatunov, A. R. Jones, S. L. Morgan, A. Pittman, R. J. Dobson, S. J. Newhouse, A. Al-Chalabi
Published in: BMC Bioinformatics, Issue 20/1, 2019, ISSN 1471-2105
DOI: 10.1186/s12859-019-2791-8

C9orf72 intermediate expansions of 24–30 repeats are associated with ALS

Author(s): Alfredo Iacoangeli, Ahmad Al Khleifat, Ashley R. Jones, William Sproviero, Aleksey Shatunov, Sarah Opie-Martin, Karen E. Morrison, Pamela J. Shaw, Christopher E. Shaw, Isabella Fogh, Richard J. Dobson, Stephen J. Newhouse, Ammar Al-Chalabi
Published in: Acta Neuropathologica Communications, Issue 7/1, 2019, ISSN 2051-5960
DOI: 10.1186/s40478-019-0724-4