Efficacy and safety of low-dose IL-2 (ld-IL-2) as a Treg enhancer for anti-neuroinflammatory therapy in newly diagnosed Amyotrophic Lateral Sclerosis (ALS) patients

Información del proyecto

MIROCALS

Identificador del acuerdo de subvención: 633413

DOI

10.3030/633413

Proyecto cerrado

Fecha de la firma de la CE 7 Abril 2015

Fecha de inicio 1 Septiembre 2015

Fecha de finalización 30 Septiembre 2021

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 6 510 741,95

Aportación de la UE

€ 5 980 435,00

Coordinado por

CENTRE HOSPITALIER UNIVERSITAIRE
France

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (2)

Approval from IRBs and Regulatory Agencies

All approval documents to start patient recruitment.

International workshops

Prospect and impact of IL2 in ALS management and New design for clinical trials in neurodegenerative diseases

Demonstrators, pilots, prototypes (1)

Corporate communication tools provided

Logo, brochure, public website

Publicaciones

Peer reviewed articles (26)

The involvement of regulatory T cells in amyotrophic lateral sclerosis and their therapeutic potential

Autores: I. Giovannelli, P. Heath, P. J. Shaw, J. Kirby
Publicado en: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Edición 21/5-6, 2020, Página(s) 435-444, ISSN 2167-8421
Editor: Informa Healthcare
DOI: 10.1080/21678421.2020.1752246

A Knowledge-Based Machine Learning Approach to Gene Prioritisation in Amyotrophic Lateral Sclerosis

Autores: Daniel Bean; Daniel Bean; Ammar Al-Chalabi; Ammar Al-Chalabi; Richard Dobson; Richard Dobson; Alfredo Iacoangeli
Publicado en: Genes, Vol 11, Iss 668, p 668 (2020), Edición 20734425, 2020, ISSN 2073-4425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes11060668

Neurofilaments can differentiate ALS subgroups and ALS from common diagnostic mimics

Autores: Arvin Behzadi; Fani Pujol-Calderón; Anton Tjust; Anna Wuolikainen; Kina Höglund; Kina Höglund; Karin Forsberg; Erik Portelius; Erik Portelius; Kaj Blennow; Kaj Blennow; Henrik Zetterberg; Peter M. Andersen
Publicado en: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021), Edición 3, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-01499-6

ALS-specific cognitive and behavior changes associated with advancing disease stage in ALS

Autores: Crockford, Christopher; Newton, Judith; Lonergan, Katie; Chiwera, Theresa; Booth, Tom; Chandran, Siddharthan; Colville, Shuna; Heverin, Mark; Mays, Iain; Pal, Suvankar; Pender, Niall; Pinto-Grau, Marta; Radakovic, Ratko; Shaw, Christopher E.; Stephenson, Laura; Swingler, Robert; Vajda, Alice; Al-Chalabi, Ammar; Hardiman, Orla; Abrahams, Sharon
Publicado en: Crockford , C , Newton , J , Lonergan , K , Chiwera , T , Booth , T , Chandran , S , Colville , S , Heverin , M , Mays , I , Pal , S , Pender , N , Pinto-Grau , M , Radakovic , R , Shaw , C E , Stephenson , L , Swingler , R , Vajda , A , Al-Chalabi , A , Hardiman , O & Abrahams , S 2018 , ' ALS-specific cognitive and behavior changes associated with advancing disease stage in ALS ' , Neurology , v, Edición 1, 2018, ISSN 0028-3878
Editor: Lippincott Williams & Wilkins Ltd.

A survey of current practices

Autores: Vajda, Alice; McLaughlin, Russell L.; Heverin, Mark; Thorpe, Owen; Abrahams, Sharon; Al-Chalabi, Ammar; Hardiman, Orla
Publicado en: Neurology, Edición 6, 2017, ISSN 0028-3878
Editor: Lippincott Williams & Wilkins Ltd.

Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis

Autores: Ahmad Al Khleifat; Alfredo Iacoangeli; Joke J. F. A. van Vugt; Harry Bowles; Matthieu Moisse; Ramona A. J. Zwamborn; Rick A. A. van der Spek; Aleksey Shatunov; Johnathan Cooper-Knock; Simon Topp; Ross Byrne; Cinzia Gellera; Victoria López; Ashley R. Jones; Sarah Opie-Martin; Atay Vural; Yolanda Campos; Wouter van Rheenen; Brendan Kenna; Kristel R. Van Eijk; Kevin Kenna; Markus Weber; Bradley Smit
Publicado en: NPJ Genomic Medicine, Edición 1, 2022, ISSN 2056-7944
Editor: Springer Nature
DOI: 10.1038/s41525-021-00267-9

DGLinker: flexible knowledge-graph prediction of disease–gene associations

Autores: Jiajing Hu; Rosalba Lepore; Richard Dobson; Richard Dobson; Ammar Al-Chalabi; Ammar Al-Chalabi; Daniel Bean; Daniel Bean; Alfredo Iacoangeli; Alfredo Iacoangeli
Publicado en: Nucleic Acids Research, Edición 3, 2021, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkab449

Repeated 5-day cycles of low dose aldesleukin in amyotrophic lateral sclerosis (IMODALS): A phase 2a randomised, double-blind, placebo-controlled trial

Autores: William Camu, Marius Mickunas, Jean-Luc Veyrune, Christine Payan, Cecilia Garlanda, Massimo Locati, Raul Juntas-Morales, Nicolas Pageot, Andrea Malaspina, Ulf Andreasson, Janine Kirby, Carey Suehs, Safa Saker, Christophe Masseguin, John De Vos, Henrik Zetterberg, Pamela J Shaw, Ammar Al-Chalabi, P Nigel Leigh, Timothy Tree, Gilbert Bensimon
Publicado en: EBioMedicine, Edición 59, 2020, Página(s) 102844, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2020.102844

The genetics of amyotrophic lateral sclerosis: current insights

Autores: Janine Kirby, Afnan Al Sultan, Rachel Waller, Paul Heath
Publicado en: Degenerative Neurological and Neuromuscular Disease, 2016, Página(s) 49, ISSN 1179-9900
Editor: Dove Press
DOI: 10.2147/dnnd.s84956

A comprehensive analysis of rare genetic variation in amyotrophic lateral sclerosis in the UK

Autores: Sarah Morgan, Aleksey Shatunov, William Sproviero, Ashley R. Jones, Maryam Shoai, Deborah Hughes, Ahmad Al Khleifat, Andrea Malaspina, Karen E. Morrison, Pamela J. Shaw, Christopher E. Shaw, Katie Sidle, Richard W. Orrell, Pietro Fratta, John Hardy, Alan Pittman, Ammar Al-Chalabi
Publicado en: Brain, Edición 140/6, 2017, Página(s) 1611-1618, ISSN 0006-8950
Editor: Oxford University Press
DOI: 10.1093/brain/awx082

Genetic testing in ALS

Autores: Alice Vajda, Russell L. McLaughlin, Mark Heverin, Owen Thorpe, Sharon Abrahams, Ammar Al-Chalabi, Orla Hardiman
Publicado en: Neurology, Edición 88/10, 2017, Página(s) 991-999, ISSN 0028-3878
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/WNL.0000000000003686

Detection of long repeat expansions from PCR-free whole-genome sequence data

Autores: Egor Dolzhenko, Joke J.F.A. van Vugt, Richard J. Shaw, Mitchell A. Bekritsky, Marka van Blitterswijk, Giuseppe Narzisi, Subramanian S. Ajay, Vani Rajan, Bryan R. Lajoie, Nathan H. Johnson, Zoya Kingsbury, Sean J. Humphray, Raymond D. Schellevis, William J. Brands, Matt Baker, Rosa Rademakers, Maarten Kooyman, Gijs H.P. Tazelaar, Michael A. van Es, Russell McLaughlin, William Sproviero, Aleksey Sha
Publicado en: Genome Research, Edición 27/11, 2017, Página(s) 1895-1903, ISSN 1088-9051
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.225672.117

Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging study

Autores: Ton Fang, Ahmad Al Khleifat, Jacques-Henri Meurgey, Ashley Jones, P Nigel Leigh, Gilbert Bensimon, Ammar Al-Chalabi
Publicado en: The Lancet Neurology, Edición 17/5, 2018, Página(s) 416-422, ISSN 1474-4422
Editor: The Lancet Publishing Group
DOI: 10.1016/S1474-4422(18)30054-1

Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases

Autores: Jason A. Chen, Zhongbo Chen, Hyejung Won, Alden Y. Huang, Jennifer K. Lowe, Kevin Wojta, Jennifer S. Yokoyama, Gilbert Bensimon, P. Nigel Leigh, Christine Payan, Aleksey Shatunov, Ashley R. Jones, Cathryn M. Lewis, Panagiotis Deloukas, Philippe Amouyel, Christophe Tzourio, Jean-Francois Dartigues, Albert Ludolph, Adam L. Boxer, Jeff M. Bronstein, Ammar Al-Chalabi, Daniel H. Geschwind, Giovanni Cop
Publicado en: Molecular Neurodegeneration, Edición 13/1, 2018, ISSN 1750-1326
Editor: BioMed Central
DOI: 10.1186/s13024-018-0270-8

The benefit of evolving multidisciplinary care in ALS: a diagnostic cohort survival comparison

Autores: Sarah Martin, Emma Trevor-Jones, Sabyha Khan, Keelan Shaw, Deepti Marchment, Anna Kulka, Catherine E Ellis, Rachel Burman, Martin R. Turner, Liam Carroll, Leah Mursaleen, P. Nigel Leigh, Christopher E. Shaw, Neil Pearce, Daniel Stahl, Ammar Al-Chalabi
Publicado en: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Edición 18/7-8, 2017, Página(s) 569-575, ISSN 2167-8421
Editor: Informa Healthcare
DOI: 10.1080/21678421.2017.1349151

Proposed association between the hexanucleotide repeat of C9orf72 and opposability index of the thumb

Autores: Zhongbo Chen, Kuang Lin, Jeffrey D. Macklis, Ammar Al-Chalabi
Publicado en: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Edición 18/3-4, 2017, Página(s) 175-181, ISSN 2167-8421
Editor: Informa Healthcare
DOI: 10.1080/21678421.2016.1257024

ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function

Autores: Martina de Majo, Simon D. Topp, Bradley N. Smith, Agnes L. Nishimura, Han-Jou Chen, Athina Soragia Gkazi, Jack Miller, Chun Hao Wong, Caroline Vance, Frank Baas, Anneloor L.M.A. ten Asbroek, Kevin P. Kenna, Nicola Ticozzi, Alberto Garcia Redondo, Jesús Esteban-Pérez, Cinzia Tiloca, Federico Verde, Stefano Duga, Karen E. Morrison, Pamela J. Shaw, Janine Kirby, Martin R. Turner, Kevin Talbot, Orla
Publicado en: Neurobiology of Aging, Edición 71, 2018, Página(s) 266.e1-266.e10, ISSN 0197-4580
Editor: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2018.06.015

Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis

Autores: Jeremy A. Garson, Louise Usher, Ammar Al-Chalabi, Jim Huggett, Edmund F. Day, Adele L. McCormick
Publicado en: Acta Neuropathologica Communications, Edición 7/1, 2019, ISSN 2051-5960
Editor: BioMed Central
DOI: 10.1186/s40478-019-0698-2

Telomere length is greater in ALS than in controls: a whole genome sequencing study

Autores: Ahmad Al Khleifat, Alfredo Iacoangeli, Aleksey Shatunov, Ton Fang, William Sproviero, Ashley R. Jones, Sarah Opie-Martin, Karen E. Morrison, Pamela J. Shaw, Christopher E. Shaw, John F. Powell, Richard Dobson, Steven J. Newhouse, Ammar Al-Chalabi
Publicado en: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Edición 20/3-4, 2019, Página(s) 229-234, ISSN 2167-8421
Editor: Informa Healthcare
DOI: 10.1080/21678421.2019.1586951

DNAscan: personal computer compatible NGS analysis, annotation and visualisation

Autores: A. Iacoangeli, A. Al Khleifat, W. Sproviero, A. Shatunov, A. R. Jones, S. L. Morgan, A. Pittman, R. J. Dobson, S. J. Newhouse, A. Al-Chalabi
Publicado en: BMC Bioinformatics, Edición 20/1, 2019, ISSN 1471-2105
Editor: BioMed Central
DOI: 10.1186/s12859-019-2791-8

C9orf72 intermediate expansions of 24–30 repeats are associated with ALS

Autores: Alfredo Iacoangeli, Ahmad Al Khleifat, Ashley R. Jones, William Sproviero, Aleksey Shatunov, Sarah Opie-Martin, Karen E. Morrison, Pamela J. Shaw, Christopher E. Shaw, Isabella Fogh, Richard J. Dobson, Stephen J. Newhouse, Ammar Al-Chalabi
Publicado en: Acta Neuropathologica Communications, Edición 7/1, 2019, ISSN 2051-5960
Editor: BioMed Central
DOI: 10.1186/s40478-019-0724-4

Younger age of onset in familial amyotrophic lateral sclerosis is a result of pathogenic gene variants, rather than ascertainment bias.

Autores: Mehta, P.R.; Jones, A.R.; Opie-Martin, S.; Shatunov, A.; Iacoangeli, A.; Al Khleifat, A.; Smith, B.N.; Topp, S.; Morrison, K.E.; Shaw, P.J.; Shaw, C.E.; Morgan, S.; Pittman, A.; Al-Chalabi, A.
Publicado en: 0022-3050, Edición 1, 2018, ISSN 0022-3050
Editor: BMJ Publishing Group

Predicting the future of ALS: the impact of demographic change and potential new treatments on the prevalence of ALS in the United Kingdom, 2020–2116

Autores: Alison Gowland; Sarah Opie-Martin; Kirsten M. Scott; Ashley R. Jones; Puja Mehta; Christine J. Batts; C M Ellis; P. Nigel Leigh; Christopher Shaw; Jemeen Sreedharan; Ammar Al-Chalabi
Publicado en: 2167-9223, Edición 5, 2019, ISSN 2167-8421
Editor: Informa Healthcare
DOI: 10.6084/m9.figshare.7969733.v1

Elongator subunit 3 (ELP3) modifies ALS through tRNA modification

Autores: André Bento-Abreu; Gunilla Jäger; Bart Swinnen; Laura Rué; Stijn Hendrickx; Ashley R. Jones; Kim A. Staats; Ines Taes; Caroline Eykens; Annelies Nonneman; Rik Nuyts; Mieke Timmers; Lara Silva; Alain Chariot; Laurent Nguyen; John Ravits; Robin Lemmens; Deirdre Cabooter; Ludo Van Den Bosch; Philip Van Damme; Ammar Al-Chalabi; Anders S. Byström; Wim Robberecht
Publicado en: Bento-Abreu , A , Jager , G , Swinnen , B , Rué , L , Hendrickx , S , Jones , A , Staats , K A , Taes , I , Eykens , C , Nonneman , A , Nuyts , R , Timmers , M , Silva , L , Chariot , A , Nguyen , L , Ravits , J , Lemmens , R , Cabooter , D , Van Den Bosch , L , Van Damme , P , Al-Chalabi , A , Bystrom , A & Robberecht , W 2018 , ' Elongator subunit 3 (ELP3) modifies ALS through tRNA modification, Edición 1, 2018, ISSN 0964-6906
Editor: Oxford University Press
DOI: 10.1093/hmg/ddy043

Relative preservation of triceps over biceps strength in upper limb-onset ALS: the ‘split elbow’

Autores: Roaya Khalaf; Sarah Martin; C M Ellis; Rachel Burman; Jemeen Sreedharan; Christopher Shaw; P. Nigel Leigh; Martin R Turner; Ammar Al-Chalabi
Publicado en: 0022-3050, Edición 1, 2019, ISSN 0022-3050
Editor: BMJ Publishing Group
DOI: 10.1136/jnnp-2018-319894

Amyotrophic lateral sclerosis transcriptomics reveals immunological effects of low-dose interleukin-2

Autores: Ilaria Giovannelli, Nadhim Bayatti, Abigail Brown, Dennis Wang, Marius Mickunas, William Camu, Jean-Luc Veyrune, Christine Payan, Cecilia Garlanda, Massimo Locati, Raul Juntas-Morales, Nicolas Pageot, Andrea Malaspina, Ulf Andreasson, Carey Suehs, Safa Saker, Christophe Masseguin, John de Vos, Henrik Zetterberg, Ammar Al-Chalabi, P Nigel Leigh, Timothy Tree, Gilbert Bensimon, Paul R Heath, Pamela
Publicado en: Brain Communications, 2021, ISSN 2632-1297
Editor: Oxford University Press
DOI: 10.1093/braincomms/fcab141

Other (2)

Occasional essay: Upper motor neuron syndrome in amyotrophic lateral sclerosis.

Autores: Michael Swash; Michael Swash; David Burke; Martin R Turner; Julian Grosskreutz; P. Nigel Leigh; Mamede deCarvalho; Matthew C. Kiernan; Matthew C. Kiernan
Publicado en: 0022-3050, 2019
Editor: BMJ
DOI: 10.1136/jnnp-2019-321938

Retrotransposons in the development and progression of amyotrophic lateral sclerosis

Autores: Savage, Abigail L; Schumann, Gerald G; Breen, Gerome; Bubb, Vivien J; Al-Chalabi, Ammar; Quinn, John P
Publicado en: Journal of Neurology, Neurosurgery, and Psychiatry, 2018
Editor: BMJ

Derechos de propiedad intelectual

Patent (6)

LOW DOSE HUMAN INTERLEUKIN-2 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

Número de solicitud/publicación: 20 21055570
Fecha: 2021-03-05
Solicitante(s): CENTRE HOSPITALIER UNIVERSITAIRE

LOW DOSE HUMAN INTERLEUKIN-2 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

Número de solicitud/publicación: 20 21055570
Fecha: 2021-03-05
Solicitante(s): THE UNIVERSITY OF SHEFFIELD

LOW DOSE HUMAN INTERLEUKIN-2 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

Número de solicitud/publicación: 20 21055570
Fecha: 2021-03-05
Solicitante(s): KING'S COLLEGE LONDON

LOW DOSE HUMAN INTERLEUKIN-2 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

Número de solicitud/publicación: 20 21055570
Fecha: 2021-03-05
Solicitante(s): THE UNIVERSITY OF SUSSEX

LOW DOSE HUMAN INTERLEUKIN-2 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

Número de solicitud/publicación: 20 21055570
Fecha: 2021-03-05
Solicitante(s): HUMANITAS MIRASOLE SPA

LOW DOSE HUMAN INTERLEUKIN-2 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

Número de solicitud/publicación: 20 21055570
Fecha: 2021-03-05
Solicitante(s): QUEEN MARY UNIVERSITY OF LONDON