Efficacy and safety of low-dose IL-2 (ld-IL-2) as a Treg enhancer for anti-neuroinflammatory therapy in newly diagnosed Amyotrophic Lateral Sclerosis (ALS) patients

Informacje na temat projektu

MIROCALS

Identyfikator umowy o grant: 633413

DOI

10.3030/633413

Projekt został zamknięty

Data podpisania przez KE 7 Kwietnia 2015

Data rozpoczęcia 1 Września 2015

Data zakończenia 30 Września 2021

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 6 510 741,95

Wkład UE

€ 5 980 435,00

Koordynowany przez

CENTRE HOSPITALIER UNIVERSITAIRE
France

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (2)

Approval from IRBs and Regulatory Agencies

All approval documents to start patient recruitment.

International workshops

Prospect and impact of IL2 in ALS management and New design for clinical trials in neurodegenerative diseases

Demonstrators, pilots, prototypes (1)

Corporate communication tools provided

Logo, brochure, public website

Publikacje

Peer reviewed articles (26)

The involvement of regulatory T cells in amyotrophic lateral sclerosis and their therapeutic potential

Autorzy: I. Giovannelli, P. Heath, P. J. Shaw, J. Kirby
Opublikowane w: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Numer 21/5-6, 2020, Strona(/y) 435-444, ISSN 2167-8421
Wydawca: Informa Healthcare
DOI: 10.1080/21678421.2020.1752246

A Knowledge-Based Machine Learning Approach to Gene Prioritisation in Amyotrophic Lateral Sclerosis

Autorzy: Daniel Bean; Daniel Bean; Ammar Al-Chalabi; Ammar Al-Chalabi; Richard Dobson; Richard Dobson; Alfredo Iacoangeli
Opublikowane w: Genes, Vol 11, Iss 668, p 668 (2020), Numer 20734425, 2020, ISSN 2073-4425
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes11060668

Neurofilaments can differentiate ALS subgroups and ALS from common diagnostic mimics

Autorzy: Arvin Behzadi; Fani Pujol-Calderón; Anton Tjust; Anna Wuolikainen; Kina Höglund; Kina Höglund; Karin Forsberg; Erik Portelius; Erik Portelius; Kaj Blennow; Kaj Blennow; Henrik Zetterberg; Peter M. Andersen
Opublikowane w: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021), Numer 3, 2021, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-021-01499-6

ALS-specific cognitive and behavior changes associated with advancing disease stage in ALS

Autorzy: Crockford, Christopher; Newton, Judith; Lonergan, Katie; Chiwera, Theresa; Booth, Tom; Chandran, Siddharthan; Colville, Shuna; Heverin, Mark; Mays, Iain; Pal, Suvankar; Pender, Niall; Pinto-Grau, Marta; Radakovic, Ratko; Shaw, Christopher E.; Stephenson, Laura; Swingler, Robert; Vajda, Alice; Al-Chalabi, Ammar; Hardiman, Orla; Abrahams, Sharon
Opublikowane w: Crockford , C , Newton , J , Lonergan , K , Chiwera , T , Booth , T , Chandran , S , Colville , S , Heverin , M , Mays , I , Pal , S , Pender , N , Pinto-Grau , M , Radakovic , R , Shaw , C E , Stephenson , L , Swingler , R , Vajda , A , Al-Chalabi , A , Hardiman , O & Abrahams , S 2018 , ' ALS-specific cognitive and behavior changes associated with advancing disease stage in ALS ' , Neurology , v, Numer 1, 2018, ISSN 0028-3878
Wydawca: Lippincott Williams & Wilkins Ltd.

A survey of current practices

Autorzy: Vajda, Alice; McLaughlin, Russell L.; Heverin, Mark; Thorpe, Owen; Abrahams, Sharon; Al-Chalabi, Ammar; Hardiman, Orla
Opublikowane w: Neurology, Numer 6, 2017, ISSN 0028-3878
Wydawca: Lippincott Williams & Wilkins Ltd.

Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis

Autorzy: Ahmad Al Khleifat; Alfredo Iacoangeli; Joke J. F. A. van Vugt; Harry Bowles; Matthieu Moisse; Ramona A. J. Zwamborn; Rick A. A. van der Spek; Aleksey Shatunov; Johnathan Cooper-Knock; Simon Topp; Ross Byrne; Cinzia Gellera; Victoria López; Ashley R. Jones; Sarah Opie-Martin; Atay Vural; Yolanda Campos; Wouter van Rheenen; Brendan Kenna; Kristel R. Van Eijk; Kevin Kenna; Markus Weber; Bradley Smit
Opublikowane w: NPJ Genomic Medicine, Numer 1, 2022, ISSN 2056-7944
Wydawca: Springer Nature
DOI: 10.1038/s41525-021-00267-9

DGLinker: flexible knowledge-graph prediction of disease–gene associations

Autorzy: Jiajing Hu; Rosalba Lepore; Richard Dobson; Richard Dobson; Ammar Al-Chalabi; Ammar Al-Chalabi; Daniel Bean; Daniel Bean; Alfredo Iacoangeli; Alfredo Iacoangeli
Opublikowane w: Nucleic Acids Research, Numer 3, 2021, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkab449

Repeated 5-day cycles of low dose aldesleukin in amyotrophic lateral sclerosis (IMODALS): A phase 2a randomised, double-blind, placebo-controlled trial

Autorzy: William Camu, Marius Mickunas, Jean-Luc Veyrune, Christine Payan, Cecilia Garlanda, Massimo Locati, Raul Juntas-Morales, Nicolas Pageot, Andrea Malaspina, Ulf Andreasson, Janine Kirby, Carey Suehs, Safa Saker, Christophe Masseguin, John De Vos, Henrik Zetterberg, Pamela J Shaw, Ammar Al-Chalabi, P Nigel Leigh, Timothy Tree, Gilbert Bensimon
Opublikowane w: EBioMedicine, Numer 59, 2020, Strona(/y) 102844, ISSN 2352-3964
Wydawca: Elsevier BV
DOI: 10.1016/j.ebiom.2020.102844

The genetics of amyotrophic lateral sclerosis: current insights

Autorzy: Janine Kirby, Afnan Al Sultan, Rachel Waller, Paul Heath
Opublikowane w: Degenerative Neurological and Neuromuscular Disease, 2016, Strona(/y) 49, ISSN 1179-9900
Wydawca: Dove Press
DOI: 10.2147/dnnd.s84956

A comprehensive analysis of rare genetic variation in amyotrophic lateral sclerosis in the UK

Autorzy: Sarah Morgan, Aleksey Shatunov, William Sproviero, Ashley R. Jones, Maryam Shoai, Deborah Hughes, Ahmad Al Khleifat, Andrea Malaspina, Karen E. Morrison, Pamela J. Shaw, Christopher E. Shaw, Katie Sidle, Richard W. Orrell, Pietro Fratta, John Hardy, Alan Pittman, Ammar Al-Chalabi
Opublikowane w: Brain, Numer 140/6, 2017, Strona(/y) 1611-1618, ISSN 0006-8950
Wydawca: Oxford University Press
DOI: 10.1093/brain/awx082

Genetic testing in ALS

Autorzy: Alice Vajda, Russell L. McLaughlin, Mark Heverin, Owen Thorpe, Sharon Abrahams, Ammar Al-Chalabi, Orla Hardiman
Opublikowane w: Neurology, Numer 88/10, 2017, Strona(/y) 991-999, ISSN 0028-3878
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/WNL.0000000000003686

Detection of long repeat expansions from PCR-free whole-genome sequence data

Autorzy: Egor Dolzhenko, Joke J.F.A. van Vugt, Richard J. Shaw, Mitchell A. Bekritsky, Marka van Blitterswijk, Giuseppe Narzisi, Subramanian S. Ajay, Vani Rajan, Bryan R. Lajoie, Nathan H. Johnson, Zoya Kingsbury, Sean J. Humphray, Raymond D. Schellevis, William J. Brands, Matt Baker, Rosa Rademakers, Maarten Kooyman, Gijs H.P. Tazelaar, Michael A. van Es, Russell McLaughlin, William Sproviero, Aleksey Sha
Opublikowane w: Genome Research, Numer 27/11, 2017, Strona(/y) 1895-1903, ISSN 1088-9051
Wydawca: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.225672.117

Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging study

Autorzy: Ton Fang, Ahmad Al Khleifat, Jacques-Henri Meurgey, Ashley Jones, P Nigel Leigh, Gilbert Bensimon, Ammar Al-Chalabi
Opublikowane w: The Lancet Neurology, Numer 17/5, 2018, Strona(/y) 416-422, ISSN 1474-4422
Wydawca: The Lancet Publishing Group
DOI: 10.1016/S1474-4422(18)30054-1

Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases

Autorzy: Jason A. Chen, Zhongbo Chen, Hyejung Won, Alden Y. Huang, Jennifer K. Lowe, Kevin Wojta, Jennifer S. Yokoyama, Gilbert Bensimon, P. Nigel Leigh, Christine Payan, Aleksey Shatunov, Ashley R. Jones, Cathryn M. Lewis, Panagiotis Deloukas, Philippe Amouyel, Christophe Tzourio, Jean-Francois Dartigues, Albert Ludolph, Adam L. Boxer, Jeff M. Bronstein, Ammar Al-Chalabi, Daniel H. Geschwind, Giovanni Cop
Opublikowane w: Molecular Neurodegeneration, Numer 13/1, 2018, ISSN 1750-1326
Wydawca: BioMed Central
DOI: 10.1186/s13024-018-0270-8

The benefit of evolving multidisciplinary care in ALS: a diagnostic cohort survival comparison

Autorzy: Sarah Martin, Emma Trevor-Jones, Sabyha Khan, Keelan Shaw, Deepti Marchment, Anna Kulka, Catherine E Ellis, Rachel Burman, Martin R. Turner, Liam Carroll, Leah Mursaleen, P. Nigel Leigh, Christopher E. Shaw, Neil Pearce, Daniel Stahl, Ammar Al-Chalabi
Opublikowane w: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Numer 18/7-8, 2017, Strona(/y) 569-575, ISSN 2167-8421
Wydawca: Informa Healthcare
DOI: 10.1080/21678421.2017.1349151

Proposed association between the hexanucleotide repeat of C9orf72 and opposability index of the thumb

Autorzy: Zhongbo Chen, Kuang Lin, Jeffrey D. Macklis, Ammar Al-Chalabi
Opublikowane w: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Numer 18/3-4, 2017, Strona(/y) 175-181, ISSN 2167-8421
Wydawca: Informa Healthcare
DOI: 10.1080/21678421.2016.1257024

ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function

Autorzy: Martina de Majo, Simon D. Topp, Bradley N. Smith, Agnes L. Nishimura, Han-Jou Chen, Athina Soragia Gkazi, Jack Miller, Chun Hao Wong, Caroline Vance, Frank Baas, Anneloor L.M.A. ten Asbroek, Kevin P. Kenna, Nicola Ticozzi, Alberto Garcia Redondo, Jesús Esteban-Pérez, Cinzia Tiloca, Federico Verde, Stefano Duga, Karen E. Morrison, Pamela J. Shaw, Janine Kirby, Martin R. Turner, Kevin Talbot, Orla
Opublikowane w: Neurobiology of Aging, Numer 71, 2018, Strona(/y) 266.e1-266.e10, ISSN 0197-4580
Wydawca: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2018.06.015

Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis

Autorzy: Jeremy A. Garson, Louise Usher, Ammar Al-Chalabi, Jim Huggett, Edmund F. Day, Adele L. McCormick
Opublikowane w: Acta Neuropathologica Communications, Numer 7/1, 2019, ISSN 2051-5960
Wydawca: BioMed Central
DOI: 10.1186/s40478-019-0698-2

Telomere length is greater in ALS than in controls: a whole genome sequencing study

Autorzy: Ahmad Al Khleifat, Alfredo Iacoangeli, Aleksey Shatunov, Ton Fang, William Sproviero, Ashley R. Jones, Sarah Opie-Martin, Karen E. Morrison, Pamela J. Shaw, Christopher E. Shaw, John F. Powell, Richard Dobson, Steven J. Newhouse, Ammar Al-Chalabi
Opublikowane w: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Numer 20/3-4, 2019, Strona(/y) 229-234, ISSN 2167-8421
Wydawca: Informa Healthcare
DOI: 10.1080/21678421.2019.1586951

DNAscan: personal computer compatible NGS analysis, annotation and visualisation

Autorzy: A. Iacoangeli, A. Al Khleifat, W. Sproviero, A. Shatunov, A. R. Jones, S. L. Morgan, A. Pittman, R. J. Dobson, S. J. Newhouse, A. Al-Chalabi
Opublikowane w: BMC Bioinformatics, Numer 20/1, 2019, ISSN 1471-2105
Wydawca: BioMed Central
DOI: 10.1186/s12859-019-2791-8

C9orf72 intermediate expansions of 24–30 repeats are associated with ALS

Autorzy: Alfredo Iacoangeli, Ahmad Al Khleifat, Ashley R. Jones, William Sproviero, Aleksey Shatunov, Sarah Opie-Martin, Karen E. Morrison, Pamela J. Shaw, Christopher E. Shaw, Isabella Fogh, Richard J. Dobson, Stephen J. Newhouse, Ammar Al-Chalabi
Opublikowane w: Acta Neuropathologica Communications, Numer 7/1, 2019, ISSN 2051-5960
Wydawca: BioMed Central
DOI: 10.1186/s40478-019-0724-4

Younger age of onset in familial amyotrophic lateral sclerosis is a result of pathogenic gene variants, rather than ascertainment bias.

Autorzy: Mehta, P.R.; Jones, A.R.; Opie-Martin, S.; Shatunov, A.; Iacoangeli, A.; Al Khleifat, A.; Smith, B.N.; Topp, S.; Morrison, K.E.; Shaw, P.J.; Shaw, C.E.; Morgan, S.; Pittman, A.; Al-Chalabi, A.
Opublikowane w: 0022-3050, Numer 1, 2018, ISSN 0022-3050
Wydawca: BMJ Publishing Group

Predicting the future of ALS: the impact of demographic change and potential new treatments on the prevalence of ALS in the United Kingdom, 2020–2116

Autorzy: Alison Gowland; Sarah Opie-Martin; Kirsten M. Scott; Ashley R. Jones; Puja Mehta; Christine J. Batts; C M Ellis; P. Nigel Leigh; Christopher Shaw; Jemeen Sreedharan; Ammar Al-Chalabi
Opublikowane w: 2167-9223, Numer 5, 2019, ISSN 2167-8421
Wydawca: Informa Healthcare
DOI: 10.6084/m9.figshare.7969733.v1

Elongator subunit 3 (ELP3) modifies ALS through tRNA modification

Autorzy: André Bento-Abreu; Gunilla Jäger; Bart Swinnen; Laura Rué; Stijn Hendrickx; Ashley R. Jones; Kim A. Staats; Ines Taes; Caroline Eykens; Annelies Nonneman; Rik Nuyts; Mieke Timmers; Lara Silva; Alain Chariot; Laurent Nguyen; John Ravits; Robin Lemmens; Deirdre Cabooter; Ludo Van Den Bosch; Philip Van Damme; Ammar Al-Chalabi; Anders S. Byström; Wim Robberecht
Opublikowane w: Bento-Abreu , A , Jager , G , Swinnen , B , Rué , L , Hendrickx , S , Jones , A , Staats , K A , Taes , I , Eykens , C , Nonneman , A , Nuyts , R , Timmers , M , Silva , L , Chariot , A , Nguyen , L , Ravits , J , Lemmens , R , Cabooter , D , Van Den Bosch , L , Van Damme , P , Al-Chalabi , A , Bystrom , A & Robberecht , W 2018 , ' Elongator subunit 3 (ELP3) modifies ALS through tRNA modification, Numer 1, 2018, ISSN 0964-6906
Wydawca: Oxford University Press
DOI: 10.1093/hmg/ddy043

Relative preservation of triceps over biceps strength in upper limb-onset ALS: the ‘split elbow’

Autorzy: Roaya Khalaf; Sarah Martin; C M Ellis; Rachel Burman; Jemeen Sreedharan; Christopher Shaw; P. Nigel Leigh; Martin R Turner; Ammar Al-Chalabi
Opublikowane w: 0022-3050, Numer 1, 2019, ISSN 0022-3050
Wydawca: BMJ Publishing Group
DOI: 10.1136/jnnp-2018-319894

Amyotrophic lateral sclerosis transcriptomics reveals immunological effects of low-dose interleukin-2

Autorzy: Ilaria Giovannelli, Nadhim Bayatti, Abigail Brown, Dennis Wang, Marius Mickunas, William Camu, Jean-Luc Veyrune, Christine Payan, Cecilia Garlanda, Massimo Locati, Raul Juntas-Morales, Nicolas Pageot, Andrea Malaspina, Ulf Andreasson, Carey Suehs, Safa Saker, Christophe Masseguin, John de Vos, Henrik Zetterberg, Ammar Al-Chalabi, P Nigel Leigh, Timothy Tree, Gilbert Bensimon, Paul R Heath, Pamela
Opublikowane w: Brain Communications, 2021, ISSN 2632-1297
Wydawca: Oxford University Press
DOI: 10.1093/braincomms/fcab141

Other (2)

Occasional essay: Upper motor neuron syndrome in amyotrophic lateral sclerosis.

Autorzy: Michael Swash; Michael Swash; David Burke; Martin R Turner; Julian Grosskreutz; P. Nigel Leigh; Mamede deCarvalho; Matthew C. Kiernan; Matthew C. Kiernan
Opublikowane w: 0022-3050, 2019
Wydawca: BMJ
DOI: 10.1136/jnnp-2019-321938

Retrotransposons in the development and progression of amyotrophic lateral sclerosis

Autorzy: Savage, Abigail L; Schumann, Gerald G; Breen, Gerome; Bubb, Vivien J; Al-Chalabi, Ammar; Quinn, John P
Opublikowane w: Journal of Neurology, Neurosurgery, and Psychiatry, 2018
Wydawca: BMJ

Prawa własności intelektualnej

Patent (6)

LOW DOSE HUMAN INTERLEUKIN-2 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

Numer wniosku/publikacji: 20 21055570
Data: 2021-03-05
Wnioskodawca/wnioskodawcy: CENTRE HOSPITALIER UNIVERSITAIRE

LOW DOSE HUMAN INTERLEUKIN-2 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

Numer wniosku/publikacji: 20 21055570
Data: 2021-03-05
Wnioskodawca/wnioskodawcy: THE UNIVERSITY OF SHEFFIELD

LOW DOSE HUMAN INTERLEUKIN-2 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

Numer wniosku/publikacji: 20 21055570
Data: 2021-03-05
Wnioskodawca/wnioskodawcy: KING'S COLLEGE LONDON

LOW DOSE HUMAN INTERLEUKIN-2 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

Numer wniosku/publikacji: 20 21055570
Data: 2021-03-05
Wnioskodawca/wnioskodawcy: THE UNIVERSITY OF SUSSEX

LOW DOSE HUMAN INTERLEUKIN-2 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

Numer wniosku/publikacji: 20 21055570
Data: 2021-03-05
Wnioskodawca/wnioskodawcy: HUMANITAS MIRASOLE SPA

LOW DOSE HUMAN INTERLEUKIN-2 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

Numer wniosku/publikacji: 20 21055570
Data: 2021-03-05
Wnioskodawca/wnioskodawcy: QUEEN MARY UNIVERSITY OF LONDON