Project description
From sensory input to decisions and motor output: neural substrates
Multicellular organisms routinely use sensory inputs to make cognitive decisions that ultimately result in motor outputs. The complexity of the brain and its circuits makes untangling the neural substrates involved in this process a challenging task. The European Research Council-funded EngineeringPercepts project will study this using the rodent’s ability to decide whether to cross a gap by detecting its far side with a single facial whisker. Combining in vivo electrophysiology, virus injections, custom imaging and reconstruction tools and Monte Carlo simulations, the team will investigate whether specific neurons in the sensory cortex receive both touch and motion information and if, when the two inputs coincide, the neural output triggers the decision to cross the gap.
Objective
Understanding how the brain is able to transform sensory input into decisions is one of the major challenges of systems neuroscience. While recording/imaging during sensory-motor tasks identified neural substrates of sensation and action in various cortical areas, the crucial questions of 1) how these correlates are implemented within the underlying neural networks and 2) how their output triggers decisions, will only be answered when the individual functional measurements are integrated into a coherent model of all task-related circuits.
The goal of my proposal is to use the rodent vibrissal system for building such a model in the context of how a tactile-mediated percept is encoded by the interplay between biophysical, cellular and network mechanisms. Specifically, rodents decide to cross a gap when detecting its far side with a single facial whisker. This suggests that whisker contact with the platform, if synchronized with an internal motor signal, triggers the decision. My key hypothesis is that in sensory cortex layer 5 thick-tufted (L5tt) neurons receive touch and motor information via specific pathways that target basal and apical tuft dendrites, respectively. When localizing the far side of the gap, the two inputs coincide and result in burst spiking output to (sub)cortical areas, triggering the gap cross.
To test this hypothesis, I will determine all sensory/motor-related local and long-range inputs/outputs to/from L5tt neurons, measure whisker-evoked responses of these populations and use the data to constrain network simulations of active whisker touch. Using a multidisciplinary approach, combining in vivo electrophysiology, virus injections, custom imaging/reconstruction tools and Monte Carlo simulations, my reverse engineering strategy will provide unmatched mechanistic insight to perceptual decision making and will function as a show case – generalizable across sensory modalities and species – of how to derive computations that underlie behavior.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences zoology mammalogy primatology
- natural sciences biological sciences neurobiology
- natural sciences biological sciences microbiology virology
- natural sciences mathematics applied mathematics statistics and probability bayesian statistics
- natural sciences computer and information sciences artificial intelligence computational intelligence
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Call for proposal
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(opens in new window) ERC-2014-STG
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80539 MUNCHEN
Germany
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