Point-of-care microfluidic device for quantification of chemotherapeutic drugs in small body fluid samples by highly selective nanoparticle extraction and liquid crystal detection

Project Information

DiaChemo

Grant agreement ID: 633635

DOI 10.3030/633635

Project closed

EC signature date 13 April 2015

Start date 1 May 2015

End date 31 October 2020

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 5 240 708,13

EU contribution € 4 654 333,00

Coordinated by

ENTE OSPEDALIERO SAVERIO DE BELLIS IRCCS
Italy

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Deliverables

Websites, patent fillings, videos etc. (1)

Project Website

Design and maintenance of the project website as an important dissemination tool.

Publications

Peer reviewed articles (9)

Microfluidics of binary liquid mixtures with temperature-dependent miscibility

Author(s): Maximiliano J. Fornerod, Esther Amstad, Stefan Guldin
Published in: Molecular Systems Design & Engineering, Issue 5/1, 2020, Page(s) 358-365, ISSN 2058-9689
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9me00127a

pH-Mediated molecular differentiation for fluorimetric quantification of chemotherapeutic drugs in human plasma

Author(s): Luis A. Serrano; Ye Yang; Elisa Salvati; Francesco Stellacci; Silke Krol; Stefan Guldin
Published in: Chemical Communications , 54 (12) pp. 1485-1488. (2018), Issue 1, 2017, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.26434/chemrxiv.5662462.v1

A new high-performance liquid chromatography-tandem mass spectrometry method for the determination of paclitaxel and 6α-hydroxy-paclitaxel in human plasma: Development, validation and application in a clinical pharmacokinetic study

Author(s): Bianca Posocco, Mauro Buzzo, Andrea Follegot, Luciana Giodini, Roberto Sorio, Elena Marangon, Giuseppe Toffoli
Published in: PLOS ONE, Issue 13/2, 2018, Page(s) e0193500, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0193500

pH-Mediated molecular differentiation for fluorimetric quantification of chemotherapeutic drugs in human plasma

Author(s): Luis A. Serrano, Ye Yang, Elisa Salvati, Francesco Stellacci, Silke Krol, Stefan Guldin
Published in: Chemical Communications, Issue 54/12, 2018, Page(s) 1485-1488, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7cc07668a

A Toolkit to Quantify Target Compounds in Thin-Layer-Chromatography Experiments

Author(s): Niamh Mac Fhionnlaoich, Stuart Ibsen, Luis A. Serrano, Alaric Taylor, Runzhang Qi, Stefan Guldin
Published in: Journal of Chemical Education, Issue 95/12, 2018, Page(s) 2191-2196, ISSN 0021-9584
Publisher: American Chemical Society
DOI: 10.1021/acs.jchemed.8b00144

A Versatile AuNP Synthetic Platform for Decoupled Control of Size and Surface Composition

Author(s): Ye Yang, Luis A. Serrano, Stefan Guldin
Published in: Langmuir, Issue 34/23, 2018, Page(s) 6820-6826, ISSN 0743-7463
Publisher: American Chemical Society
DOI: 10.1021/acs.langmuir.8b00353

Microfluidics of binary liquid mixtures with temperature-dependent miscibility

Author(s): Fornerod, Maximiliano J.; Amstad, Esther; Guldin, Stefan
Published in: Molecular Systems Design & Engineering (2019) (In press)., Issue 95/12, 2019, Page(s) N/A, ISSN 1908-8922
Publisher: Royal Society of Chemistry
DOI: 10.26434/chemrxiv.6970301.v2

Probing the interaction of nanoparticles with small molecules in real time via quartz crystal microbalance monitoring

Author(s): Ye Yang, Guillaume Poss, Yini Weng, Runzhang Qi, Hanrui Zheng, Nikolaos Nianias, Euan R. Kay, Stefan Guldin
Published in: Nanoscale, Issue 11/23, 2019, Page(s) 11107-11113, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9nr03162f

Phase behaviour and applications of a binary liquid mixture of methanol and a thermotropic liquid crystal

Author(s): Luis A. Serrano, Maximiliano J. Fornerod, Ye Yang, Simon Gaisford, Francesco Stellacci, Stefan Guldin
Published in: Soft Matter, Issue 14/22, 2018, Page(s) 4615-4620, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8sm00327k

Book chapters (1)

Noble metal nanoparticles with anisotropy in shape and surface functionality for biomedical applications

Author(s): Domenico Marson, Ye Yang, Stefan Guldin, Paola Posocco
Published in: Anisotropic Particle Assemblies, 2018, Page(s) 313-333, ISBN 9780-128040690
Publisher: Elsevier
DOI: 10.1016/b978-0-12-804069-0.00011-3

Non-peer reviewed articles (1)

Reversible microscale assembly of nanoparticles driven by the phase transition of a thermotropic liquid crystal

Author(s): Niamh Mac Fhionnlaoich Stephen Schrettl Nicholas B. Tito Ye Yang Malavika Nair Luis A. Serrano Kellen Harkness Paulo Jacob Silva Holger Frauenrath Francesco Stellacci Stefan Guldin
Published in: ChemRXIV, 2018, ISSN 0306-0012
Publisher: Royal Society of Chemistry