Skip to main content

Point-of-care microfluidic device for quantification of chemotherapeutic drugs in small body fluid samples by highly selective nanoparticle extraction and liquid crystal detection

Objective

The decision-making in chemotherapy nowadays depends on standard methods that are liquid chromatography (LC-MS/MS) followed by mass spectrometry or capillary electrophoresis; both are labour- and cost-intensive and can be performed only in dedicated hospitals and laboratories. This lead to a minimal therapeutic drug monitoring in patients and hence that 30-60% of drugs are administered without clinical benefits.

We propose to develop a point-of-care device for quantification of chemotherapeutic drugs in small body fluid samples by highly selective nanoparticle extraction and liquid crystal detection incorporated in microfluidic lab-on-chip device (optofluidics based) allowing the real-time drug monitoring. This will improve the therapeutic outcome and reduced health care costs.

Field of science

  • /engineering and technology/materials engineering/liquid crystal

Call for proposal

H2020-PHC-2014-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

ENTE OSPEDALIERO SAVERIO DE BELLIS IRCCS
Address
Via Turi 27
70013 Castellana Grotte Ba
Italy
Activity type
Research Organisations
EU contribution
€ 293 636,40

Participants (10)

EUROPEAN RESEARCH SERVICES GMBH
Germany
EU contribution
€ 137 600
Address
Roentgenstrasse 19
48149 Muenster
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LIONIX INTERNATIONAL BV
Netherlands
EU contribution
€ 587 000
Address
Hengelosestraat 500
7521 AN Enschede
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CENTRO DI RIFERIMENTO ONCOLOGICO DI AVIANO
Italy
EU contribution
€ 716 375
Address
Via Franco Gallini 2
33081 Aviano Pn
Activity type
Research Organisations
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Germany
EU contribution
€ 984 208
Address
Schlossplatz 2
48149 Muenster
Activity type
Higher or Secondary Education Establishments
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
EU contribution
€ 0
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 849 400
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
PROVENION GMBH

Participation ended

Germany
EU contribution
€ 186 249,74
Address
Georg-wimmer-ring 25
85604 Zorneding
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA

Participation ended

Italy
EU contribution
€ 2 900,90
Address
Via Giovanni Celoria 11
20133 Milano
Activity type
Research Organisations
"INSTITUTO TUMORI ""GIOVANNI PAOLO II"""

Participation ended

Italy
EU contribution
€ 129 712,70
Address
Via Orazio Flacco 65
70126 Bari
Activity type
Research Organisations
VERMES MICRODISPENSING GMBH
Germany
EU contribution
€ 767 250,26
Address
Rudolf-diesel-ring 2
83607 Holzkirchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)