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Point-of-care microfluidic device for quantification of chemotherapeutic drugs in small body fluid samples by highly selective nanoparticle extraction and liquid crystal detection

Objective

The decision-making in chemotherapy nowadays depends on standard methods that are liquid chromatography (LC-MS/MS) followed by mass spectrometry or capillary electrophoresis; both are labour- and cost-intensive and can be performed only in dedicated hospitals and laboratories. This lead to a minimal therapeutic drug monitoring in patients and hence that 30-60% of drugs are administered without clinical benefits.

We propose to develop a point-of-care device for quantification of chemotherapeutic drugs in small body fluid samples by highly selective nanoparticle extraction and liquid crystal detection incorporated in microfluidic lab-on-chip device (optofluidics based) allowing the real-time drug monitoring. This will improve the therapeutic outcome and reduced health care costs.

Call for proposal

H2020-PHC-2014-2015

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Sub call

H2020-PHC-2014-two-stage

Coordinator

ENTE OSPEDALIERO SAVERIO DE BELLIS IRCCS
Net EU contribution
€ 293 636,40
Address
Via Turi 27
70013 Castellana Grotte Ba
Italy

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Region
Sud Puglia Bari
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (10)

EUROPEAN RESEARCH SERVICES GMBH
Germany
Net EU contribution
€ 137 600,00
Address
Roentgenstrasse 19
48149 Muenster

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Region
Nordrhein-Westfalen Münster Münster, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
LIONIX INTERNATIONAL BV
Netherlands
Net EU contribution
€ 587 000,00
Address
Hengelosestraat 500
7521 AN Enschede

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Oost-Nederland Overijssel Twente
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
CENTRO DI RIFERIMENTO ONCOLOGICO DI AVIANO
Italy
Net EU contribution
€ 716 375,00
Address
Via Franco Gallini 2
33081 Aviano Pn

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Region
Nord-Est Friuli-Venezia Giulia Pordenone
Activity type
Research Organisations
Non-EU contribution
€ 0,00
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Germany
Net EU contribution
€ 984 208,00
Address
Schlossplatz 2
48149 Muenster

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Region
Nordrhein-Westfalen Münster Münster, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,13
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
Net EU contribution
€ 0,00
Address
Batiment Ce 3316 Station 1
1015 Lausanne

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Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 586 375,00
UNIVERSITY COLLEGE LONDON
United Kingdom
Net EU contribution
€ 849 400,00
Address
Gower Street
WC1E 6BT London

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Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
PROVENION GMBH

Participation ended

Germany
Net EU contribution
€ 186 249,74
Address
Georg-wimmer-ring 25
85604 Zorneding

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bayern Oberbayern Ebersberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA

Participation ended

Italy
Net EU contribution
€ 2 900,90
Address
Via Giovanni Celoria 11
20133 Milano

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Region
Nord-Ovest Lombardia Milano
Activity type
Research Organisations
Non-EU contribution
€ 0,00
"INSTITUTO TUMORI ""GIOVANNI PAOLO II"""

Participation ended

Italy
Net EU contribution
€ 129 712,70
Address
Via Orazio Flacco 65
70126 Bari

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Region
Sud Puglia Bari
Activity type
Research Organisations
Non-EU contribution
€ 0,00
VERMES MICRODISPENSING GMBH
Germany
Net EU contribution
€ 767 250,26
Address
Rudolf-diesel-ring 2
83607 Holzkirchen

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Region
Bayern Oberbayern Miesbach
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00