ULTRAsensitive PLAsmonic devices for early CAncer Diagnosis

Objective

Cancer biomarkers circulating in body fluids have been shown to reflect the pathological process and for this reason can be used for cancer diagnosis, prognosis and choice for therapeutic interventions. It is proven that their detection is a key to new minimal-invasive detection approaches. However, barriers to wide spread use of similar approaches are lack of test sensitivity, specificity and limited availability of low cost detection platforms. This project is focused at developing a compact plasmonic-based device with integrated microfluidic circuit and functionalized nanostructures for the detection of DNA, microRNA and tumor autoantibodies cancer biomarkers.

The aim is to detect cancer biomarkers circulating in blood with improvement in sensitivity of factor up to 1000, reduction in cost of platform of factor ranging from 2 to 4 compared to today’s available techniques and analysis time less than 60 minutes. The proposed detection approache will provide ultrasensitive detection of biomolecular systems with no need for complex sample chemical modifications thus allowing direct and simple assays to be performed. Within the project a bimodal industrial prototype will be developed integrating novel surface plasmon resonance imaging and plasmon-enhanced fluorescence sensing technologies, respectively. Automated fabrication processes suitable for low cost mass production will be developed and applied to produce disposable integrated chips. Prototype will be specifically fabricated for early diagnosis and prognosis of colorectal cancer. The team includes partners holding cross-disciplinary competencies needed to achieve the proposed results, including two of the first five plasmon resonance groups in the world, the inventor of surface plasmon microscopy – also known as surface plasmon resonance imaging- and plasmon-enhanced fluorescence spectroscopy, and full European value chain including disposable chip and readout platforms design, development and manufacturing.

Field of science

• /medical and health sciences/clinical medicine/cancer/colorectal cancer
• /natural sciences/biological sciences/genetics and heredity/dna
• /natural sciences/biological sciences/biochemistry/biomolecules/proteins
• /social sciences/sociology/demography/mortality
• /medical and health sciences/clinical medicine/cancer/breast cancer
• /natural sciences/biological sciences/genetics and heredity/mutation
• /natural sciences/physical sciences/classical mechanics/fluid mechanics/microfluidics
• /natural sciences/biological sciences/biochemistry/biomolecules/nucleic acid

Programme(s)

• H2020-EU.3.1.3. - Treating and managing disease

Topic(s)

• PHC-10-2014 - Development of new diagnostic tools and technologies: in vitro devices, assays and platforms

Call for proposal

H2020-PHC-2014-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS

Address

Viale Medaglie D'oro 305
00136 Rome
Italy

Activity type

Research Organisations

EU contribution

€ 833 487,50

Participants (12)

AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH

Austria

EU contribution

€ 972 708,75

Address

Giefinggasse 4
1210 Wien

Activity type

Research Organisations

USTAV FOTONIKY A ELEKTRONIKY AV CR V.V.I.

Czechia

EU contribution

€ 313 125

Address

Kobylisy Chaberska 57
182 51 Praha 8

Activity type

Research Organisations

ISTITUTI FISIOTERAPICI OSPITALIERI

Italy

EU contribution

€ 407 375

Address

Via Chianesi 53
00144 Roma

Activity type

Other

UNIVERSITEIT TWENTE

Netherlands

EU contribution

€ 343 750

Address

Drienerlolaan 5
7522 NB Enschede

Activity type

Higher or Secondary Education Establishments

UNIVERSITAET SIEGEN

Germany

EU contribution

€ 307 300

Address

Adolf Reichwein Strasse 2A
57076 Siegen

Activity type

Higher or Secondary Education Establishments

UNIVERSITA DEGLI STUDI DI FERRARA

Italy

EU contribution

€ 213 750

Address

Via Ariosto 35
44121 Ferrara

Activity type

Higher or Secondary Education Establishments

TEKNOLOGIAN TUTKIMUSKESKUS VTT OY

Finland

EU contribution

€ 630 536,25

Address

Tekniikantie 21
02150 Espoo

Activity type

Research Organisations

SCRIBA NANOTECNOLOGIE SRL

Italy

EU contribution

€ 270 250

Address

Via Di Corticella 183/8
40128 Bologna

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

GINOLIS OY

Finland

EU contribution

€ 403 125

Address

Automaatiotie 1
90460 Oulunsalo

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

FUTURE DIAGNOSTICS SOLUTIONS BV

Netherlands

EU contribution

€ 524 375

Address

Nieuweweg 279
6603 BN Wijchen

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

HORIBA FRANCE SAS

France

EU contribution

€ 646 922,50

Address

14 Boulevard Thomas Gobert Passage Jobin Yvon Cs 4
91120 Palaiseau

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

AMIRES SRO

Czechia

EU contribution

€ 159 750

Address

Stavitelska 1099/6
160 00 Praha 6

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)