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Application of omics-based strategies for improved diagnosis and treatment of endocrine hypertension

Objectif

Arterial hypertension affects up to 45% of the general population and is responsible for 7.1 million deaths per year worldwide. Although a large therapeutic arsenal exists, blood pressure control is sub-optimal in up to two thirds of patients. Yet, even small increments in blood pressure are associated with increased cardiovascular risk, with 62% of cerebrovascular disease and 49% of ischemic heart disease being attributable to hypertension.
Detection of secondary forms of hypertension is key to targeted management of the underlying disease and prevention of cardiovascular complications. Endocrine forms of hypertension represent major targets for stratified approaches of health promotion. They include a group of adrenal disorders resulting in increased production of hormones affecting blood pressure regulation: primary aldosteronism (PA), pheochromocytoma/functional paraganglioma (PPGL) and Cushing’s syndrome (CS). These diseases are associated with increased cardiovascular and metabolic risk and with diminished quality of life.
This project will develop and evaluate an omics-based stratified health promotion program for patients with endocrine forms of hypertension. We will define specific omics profiles for patients with PA, PPGL and CS by integrating high throughput genetics, genomics and metabolomics data with phenome annotations through bioinformatics modelling. Established profiles will be validated as stratification biomarkers and applied to the screening of referred hypertensive patients for both stratifying primary forms of hypertension for effective and cost efficient therapy as well as improving identification of endocrine causes for curative treatment and prevention of cardiovascular and metabolic complications. Omics-based profiling should allow identification of patients with preclinical phenotypes along with those hypertensives that cluster into specific endocrine groups who may benefit from personalised treatment.

Champ scientifique

  • /sciences médicales et de la santé/médecine clinique/angiologie/maladies vasculaires/maladies cérébrovasculaires

Appel à propositions

H2020-PHC-2014-two-stage
Voir d’autres projets de cet appel

Régime de financement

RIA - Research and Innovation action

Coordinateur

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Adresse
Rue De Tolbiac 101
75654 Paris
France
Type d’activité
Research Organisations
Contribution de l’UE
€ 1 443 501

Participants (12)

ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
Contribution de l’UE
€ 988 500
Adresse
3 Avenue Victoria
75000 Paris
Type d’activité
Research Organisations
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Allemagne
Contribution de l’UE
€ 17 871,64
Adresse
Geschwister Scholl Platz 1
80539 Muenchen
Type d’activité
Higher or Secondary Education Establishments
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Allemagne
Contribution de l’UE
€ 534 048,36
Adresse
Ingolstadter Landstrasse 1
85764 Neuherberg
Type d’activité
Research Organisations
TECHNISCHE UNIVERSITAET DRESDEN
Allemagne
Contribution de l’UE
€ 446 459
Adresse
Helmholtzstrasse 10
01069 Dresden
Type d’activité
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI TORINO
Italie
Contribution de l’UE
€ 285 969
Adresse
Via Giuseppe Verdi 8
10124 Torino
Type d’activité
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI PADOVA
Italie
Contribution de l’UE
€ 734 500
Adresse
Via 8 Febbraio 2
35122 Padova
Type d’activité
Higher or Secondary Education Establishments
UNIVERSITY OF DUNDEE
United Kingdom
Contribution de l’UE
€ 1 011 755
Adresse
Nethergate
DD1 4HN Dundee
Type d’activité
Higher or Secondary Education Establishments
UNIVERSITY OF GLASGOW
United Kingdom
Contribution de l’UE
€ 766 380
Adresse
University Avenue
G12 8QQ Glasgow
Type d’activité
Higher or Secondary Education Establishments
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
Contribution de l’UE
€ 309 326
Adresse
Edgbaston
B15 2TT Birmingham
Type d’activité
Higher or Secondary Education Establishments
STICHTING KATHOLIEKE UNIVERSITEIT
Pays-Bas
Contribution de l’UE
€ 660 653
Adresse
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Type d’activité
Higher or Secondary Education Establishments
UNIVERSITY OF MELBOURNE
Australie
Contribution de l’UE
€ 0
Adresse
Parkvilleoffice Of The Vice Chancellor
3010 Melbourne
Type d’activité
Higher or Secondary Education Establishments
INSERM TRANSFERT SA
France
Contribution de l’UE
€ 408 374
Adresse
Rue Watt 7
75013 Paris
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)