Description du projet
Stratification des patients atteints d’hypertension d’origine endocrine
L’hypertension artérielle touche près de la moitié de la population générale. Malgré un arsenal thérapeutique important, le contrôle de la pression artérielle n’est pas efficace chez de nombreux patients. Même de faibles augmentations de la pression artérielle peuvent accroître le risque cardiovasculaire, ce qui souligne l’importance de détecter les formes secondaires d’hypertension pour prévenir les complications cardiovasculaires. Les formes endocriniennes d’hypertension comprennent un groupe de troubles surrénaliens caractérisés par une production accrue d’hormones qui affectent la régulation de la pression artérielle. Ces formes sont associées à un risque cardiovasculaire et métabolique accru. Le projet EVSAT-HT, financé par l’UE, développera et évaluera un programme de stratification des patients atteints de formes endocriniennes d’hypertension basé sur le profilage omique. Cette approche devrait permettre d’identifier les patients appartenant à des groupes endocriniens spécifiques qui pourraient bénéficier d’un traitement personnalisé.
Objectif
Arterial hypertension affects up to 45% of the general population and is responsible for 7.1 million deaths per year worldwide. Although a large therapeutic arsenal exists, blood pressure control is sub-optimal in up to two thirds of patients. Yet, even small increments in blood pressure are associated with increased cardiovascular risk, with 62% of cerebrovascular disease and 49% of ischemic heart disease being attributable to hypertension.
Detection of secondary forms of hypertension is key to targeted management of the underlying disease and prevention of cardiovascular complications. Endocrine forms of hypertension represent major targets for stratified approaches of health promotion. They include a group of adrenal disorders resulting in increased production of hormones affecting blood pressure regulation: primary aldosteronism (PA), pheochromocytoma/functional paraganglioma (PPGL) and Cushing’s syndrome (CS). These diseases are associated with increased cardiovascular and metabolic risk and with diminished quality of life.
This project will develop and evaluate an omics-based stratified health promotion program for patients with endocrine forms of hypertension. We will define specific omics profiles for patients with PA, PPGL and CS by integrating high throughput genetics, genomics and metabolomics data with phenome annotations through bioinformatics modelling. Established profiles will be validated as stratification biomarkers and applied to the screening of referred hypertensive patients for both stratifying primary forms of hypertension for effective and cost efficient therapy as well as improving identification of endocrine causes for curative treatment and prevention of cardiovascular and metabolic complications. Omics-based profiling should allow identification of patients with preclinical phenotypes along with those hypertensives that cluster into specific endocrine groups who may benefit from personalised treatment.
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RIA - Research and Innovation actionCoordinateur
75654 Paris
France