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Advanced nanophotonic point-of-care analysis device for fast and early diagnosis of cardiovascular diseases

Objectif

The PHOCNOSIS project aims at the development and the preclinical validation of a nanotechnology-based handheld point-of-care testing (POCT) analysis device for its application in the early diagnosis of cardiovascular diseases (CVD). The diagnosis will be carried out by means of the fast (<10 minutes), ultra-sensitive (<1 ng/L) and label-free detection of multiple cardiac biomarkers, using a small volume of whole blood (<100 μL). This POCT analysis device will significantly help in the implementation of mass screening programs, with the consequent impact on clinical management, reducing also costs of treatments, and increasing survival rates.
The PHOCNOSIS analysis device will be based on two state-of-the-art technological elements in order to obtain a compact and highly sensitive final device. First, an integrated micro-/nanofluidic system will be used for biomarkers separation, purification and concentration, targeting an effective concentration increase by a factor greater than 1000x for the targeted biomarkers. Then, the concentrated biomarkers will be detected using a novel nanophotonic-based sensing technique, envisaging a final combined detection limit below 1 ng/L. This novel sensing technique allows us to obtain systems which are low-cost, compact and with a lower complexity, thus making them suitable for the development of portable devices for POCT. The PHOCNOSIS project will target the deployment of disposable biochips with an envisaged cost below €3 to be used in a handheld analysis device with an envisaged cost below €3000.
Special attention will be paid within the PHOCNOSIS project to explore the potential deployment and commercialisation of the analysis device, by means of the involvement of relevant academic and industrial partners, as well as end users.

Appel à propositions

H2020-PHC-2014-two-stage
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Coordinateur

UNIVERSITAT POLITECNICA DE VALENCIA
Adresse
Camino De Vera Sn Edificio 3A
46022 Valencia
Espagne
Type d’activité
Higher or Secondary Education Establishments
Contribution de l’UE
€ 1 097 891

Participants (10)

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Allemagne
Contribution de l’UE
€ 409 050
Adresse
Hansastrasse 27C
80686 Munchen
Type d’activité
Research Organisations
UNIVERSITEIT TWENTE
Pays-Bas
Contribution de l’UE
€ 423 731
Adresse
Drienerlolaan 5
7522 NB Enschede
Type d’activité
Higher or Secondary Education Establishments
AALBORG UNIVERSITET
Danemark
Contribution de l’UE
€ 344 915
Adresse
Fredrik Bajers Vej 7K
9220 Aalborg
Type d’activité
Higher or Secondary Education Establishments
CDA GMBH
Allemagne
Contribution de l’UE
€ 336 537,50
Adresse
Am Mittelrain 11
98529 Suhl Ot Albrechts
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EV GROUP E. THALLNER GMBH
Autriche
Contribution de l’UE
€ 257 650
Adresse
Di Erich Thallner Strasse 1
4782 St Florian Am Inn
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIONOS BIOTECH SL
Espagne
Contribution de l’UE
€ 227 000
Adresse
Bulev Sur S/n - Biopolo La Fe Edificio Torre A Ho
46029 Valencia
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ART OF TECHNOLOGY AG
Suisse
Contribution de l’UE
€ 0
Adresse
Technoparkstrasse 1
8005 Zurich
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ST GEORGE'S HOSPITAL MEDICAL SCHOOL
United Kingdom
Contribution de l’UE
€ 315 937,50
Adresse
Cranmer Terrace
SW17 0RE London
Type d’activité
Higher or Secondary Education Establishments
GENERA BIOTECH SL

Participation terminée

Espagne
Contribution de l’UE
€ 49 734,44
Adresse
C/ Catedratico Agustin Escardino 9
46980 Paterna Valencia
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DB VENTURE BUILDER SL
Espagne
Contribution de l’UE
€ 131 515,56
Adresse
Calle Antonio Suarez 27 1 1
46021 Valencia
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)