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Elucidating Pathways of Steatohepatitis

Objective

Strongly associated with the epidemics of obesity and type 2 diabetes mellitus (T2DM) that are testing healthcare systems worldwide, Non-Alcoholic Fatty Liver Disease (NAFLD) is an increasingly common cause of advanced liver disease in the aging population of Europe. NAFLD is a spectrum of hepatic fat accumulation (steatosis); steatosis plus inflammation (non-alcoholic steatohepatitis, NASH); fibrosis/cirrhosis; and hepatocellular carcinoma in the absence of high alcohol consumption.
Up to 30% of the EU population have NAFLD, which will be the main aetiology underlying liver transplants by 2020. However, NAFLD is characterized by substantial inter-patient variability in severity and rate of progression. What determines this is unknown. A large population is at risk, but only some experience morbidity. NAFLD severity is currently best assessed by liver biopsy, an invasive, costly and risky procedure - factors that hinder treatment. There is a need to understand the biological and environmental factors that drive inter-patient variability and to develop robust and more acceptable methods for diagnosis, risk stratification and therapy so that effective medical care may be targeted to those that will benefit most.
The overall EPoS concept is that improved understanding of pathogenic processes and drivers of disease progression will best be achieved when multiple ‘omics’ approaches are applied to a single cohort of patients to build a multi-dimensional record of how systems are perturbed across the entire spectrum of disease. NAFLD sits at the intersection of key biological processes: carbohydrate/lipid homeostasis, immune/inflammatory activation, wound healing/fibrosis and cancer biology. Once completed, EPoS promises to deliver a substantial and definitive atlas of pathophysiological variation across a spectrum of progressive liver disease. Translation of these findings will therefore impact on closely related pathologies including T2DM and cardiovascular disease.

Call for proposal

H2020-PHC-2014-two-stage
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Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITY OF NEWCASTLE UPON TYNE
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 629 948,50

Participants (10)

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 517 990
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
INST CARDIOMETABOLISME NUTRITION ICAN
France
EU contribution
€ 1 012 317,50
Address
Boulevard De L'hopital 47-83
75013 Paris
Activity type
Research Organisations
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 130 000
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
NOVO NORDISK INVEST 4 A/S

Participation ended

Denmark
EU contribution
€ 184 256
Address
Novo Alle 1
2880 Bagsvaerd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITA DEGLI STUDI DI TORINO
Italy
EU contribution
€ 662 635
Address
Via Giuseppe Verdi 8
10124 Torino
Activity type
Higher or Secondary Education Establishments
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 533 065
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Germany
EU contribution
€ 261 000
Address
Langenbeckstrasse 1
55131 Mainz
Activity type
Higher or Secondary Education Establishments
NORDIC BIOSCIENCE A/S
Denmark
EU contribution
€ 187 500
Address
Herlev Hovedgade 205-207
2730 Herlev
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
IXSCIENT LIMITED
United Kingdom
EU contribution
€ 298 750
Address
Popes Grove 76
TW1 4JX Twickenham Middlesex
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
OREBRO UNIVERSITY
Sweden
EU contribution
€ 568 059
Address
Fakultetsgatan 1
70182 Orebro
Activity type
Higher or Secondary Education Establishments