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Elucidating Pathways of Steatohepatitis

Deliverables

Detailed dissemination plan

Detailed dissemination plan

Final reports summarising recruitment into the EPoS database, biobanked samples availability, and longitudinal outcome studies

Final reports summarising recruitment into the EPoS database, biobanked samples availability, and longitudinal outcome studies

Report on data management plan for the EPoS project

Report on data management plan for the EPoS project

Project Handbook

Project Handbook

Risk assessment procedure

Risk assessment procedure

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Publications

Relationship Among Fatty Liver, Specific and Multiple‐Site Atherosclerosis, and 10‐Year Framingham Score

Author(s): Raluca Pais, Alban Redheuil, Philippe Cluzel, Vlad Ratziu, Philippe Giral
Published in: Hepatology, 69/4, 2019, Page(s) 1453-1463, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.30223

Health-related Quality of Life in Nonalcoholic Fatty Liver Disease Associates With Hepatic Inflammation

Author(s): Yvonne Huber, Marie Boyle, Kate Hallsworth, Dina Tiniakos, Beate K. Straub, Christian Labenz, Christian Ruckes, Peter R. Galle, Manuel Romero-Gómez, Quentin M. Anstee, Jörn M. Schattenberg
Published in: Clinical Gastroenterology and Hepatology, 17/10, 2019, Page(s) 2085-2092.e1, ISSN 1542-3565
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.cgh.2018.12.016

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

Author(s): Judith Aron-Wisnewsky, Chloé Vigliotti, Julia Witjes, Phuong Le, Adriaan G. Holleboom, Joanne Verheij, Max Nieuwdorp, Karine Clément
Published in: Nature Reviews Gastroenterology & Hepatology, 17/5, 2020, Page(s) 279-297, ISSN 1759-5045
Publisher: Nature Publishing Group
DOI: 10.1038/s41575-020-0269-9

Usefulness of the index of NASH - ION for the diagnosis of steatohepatitis in patients with non-alcoholic fatty liver: An external validation study

Author(s): Ramy Younes, Chiara Rosso, Salvatore Petta, Monica Cucco, Milena Marietti, Gian Paolo Caviglia, Alessia Ciancio, Maria Lorena Abate, Carlo Cammà, Antonina Smedile, Antonio Craxì, Giorgio Maria Saracco, Elisabetta Bugianesi
Published in: Liver International, 38/4, 2018, Page(s) 715-723, ISSN 1478-3223
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/liv.13612

Predictors of advanced fibrosis in non-cirrhotic non-alcoholic fatty liver disease in Germany

Author(s): Christian Labenz, Yvonne Huber, Eva Kalliga, Michael Nagel, Christian Ruckes, Beate K. Straub, Peter R. Galle, Marcus-Alexander Wörns, Quentin M. Anstee, Detlef Schuppan, Jörn M. Schattenberg
Published in: Alimentary Pharmacology & Therapeutics, 48/10, 2018, Page(s) 1109-1116, ISSN 0269-2813
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/apt.14976

Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort☆

Author(s): Quentin M. Anstee, Rebecca Darlay, Simon Cockell, Marica Meroni, Olivier Govaere, Dina Tiniakos, Alastair D. Burt, Pierre Bedossa, Jeremy Palmer, Yang-Lin Liu, Guruprasad P. Aithal, Michael Allison, Hannele Yki-Järvinen, Michele Vacca, Jean-Francois Dufour, Pietro Invernizzi, Daniele Prati, Mattias Ekstedt, Stergios Kechagias, Sven Francque, Salvatore Petta, Elisabetta Bugianesi, Karine Clement,
Published in: Journal of Hepatology, 73/3, 2020, Page(s) 505-515, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2020.04.003

Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular Carcinoma

Author(s): Zoe Hall, Davide Chiarugi, Evelina Charidemou, Jack Leslie, Emma Scott, Luca Pellegrinet, Michael Allison, Gabriele Mocciaro, Quentin M. Anstee, Gerard I. Evan, Matthew Hoare, Antonio Vidal‐Puig, Fiona Oakley, Michele Vacca, Julian L. Griffin
Published in: Hepatology, 73/3, 2021, Page(s) 1028-1044, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.31391

Caucasian lean subjects with non-alcoholic fatty liver disease share long-term prognosis of non-lean: time for reappraisal of BMI-driven approach?

Author(s): Ramy Younes, Olivier Govaere, Salvatore Petta, Luca Miele, Dina Tiniakos, Alastair Burt, Ezio David, Fabio Maria Vecchio, Marco Maggioni, Daniela Cabibi, Duncan McLeod, Maria Jesus Pareja, Anna Ludovica Fracanzani, Rocio Aller, Chiara Rosso, Javier Ampuero, Rocío Gallego-Durán, Angelo Armandi, Gian Paolo Caviglia, Marco Y W Zaki, Antonio Liguori, Paolo Francione, Grazia Pennisi, Antonio Grieco,
Published in: Gut, 2021, Page(s) gutjnl-2020-322564, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-322564

Clinical implications of hepatic progenitor cell activation in non-alcoholic fatty liver disease

Author(s): Ramy Younes, Rachel Burgoyne, Dina Tiniakos, Olivier Govaere
Published in: Hepatoma Research, 2021, 2021, ISSN 2454-2520
Publisher: -
DOI: 10.20517/2394-5079.2020.119

Quantitative PCR provides a simple and accessible method for quantitative microbiota profiling

Author(s): Ching Jian, Panu Luukkonen, Hannele Yki-Järvinen, Anne Salonen, Katri Korpela
Published in: PLOS ONE, 15/1, 2020, Page(s) e0227285, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0227285

Elevated serum ceramides are linked with obesity-associated gut dysbiosis and impaired glucose metabolism

Author(s): Brandon D. Kayser, Edi Prifti, Marie Lhomme, Eugeni Belda, Maria-Carlota Dao, Judith Aron-Wisnewsky, Anatol Kontush, Jean-Daniel Zucker, Salwa W. Rizkalla, Isabelle Dugail, Karine Clément
Published in: Metabolomics, 15/11, 2019, ISSN 1573-3882
Publisher: Springer Verlag
DOI: 10.1007/s11306-019-1596-0

Interplay between metabolic derangement, hepatic fibrogenesis and macrophage activation in non-diabetic patients with non-alcoholic fatty liver disease

Author(s): C. Rosso, R. Younes, D.J. Leeming, R. Surabattula, G.P. Caviglia, M. Gaggini, A. Armandi, A. Olivero, M.L. Abate, A. Gastaldelli, D. Schuppan, E. Bugianesi
Published in: Digestive and Liver Disease, 52, 2020, Page(s) e10, ISSN 1590-8658
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.dld.2019.12.025

Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease

Author(s): Tuulia Hyötyläinen, Livnat Jerby, Elina M. Petäjä, Ismo Mattila, Sirkku Jäntti, Petri Auvinen, Amalia Gastaldelli, Hannele Yki-Järvinen, Eytan Ruppin, Matej Orešič
Published in: Nature Communications, 7, 2016, Page(s) 8994, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms9994

Nutritional Modulation of Non-Alcoholic Fatty Liver Disease and Insulin Resistance

Author(s): Hannele Yki-Järvinen
Published in: Nutrients, 7/11, 2015, Page(s) 9127-9138, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu7115454

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

Author(s): Zobair Younossi, Quentin M. Anstee, Milena Marietti, Timothy Hardy, Linda Henry, Mohammed Eslam, Jacob George, Elisabetta Bugianesi
Published in: Nature Reviews Gastroenterology & Hepatology, 15/1, 2017, Page(s) 11-20, ISSN 1759-5045
Publisher: Nature Publishing Group
DOI: 10.1038/nrgastro.2017.109

Phosphorylated IGFBP-1 as a non-invasive predictor of liver fat in NAFLD

Author(s): Elina M. Petäjä, You Zhou, Marika Havana, Antti Hakkarainen, Nina Lundbom, Jarkko Ihalainen, Hannele Yki-Järvinen
Published in: Scientific Reports, 6/1, 2016, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep24740

Fibrogenesis assessed by serological type III collagen formation identifies patients with progressive liver fibrosis and responders to a potential antifibrotic therapy

Author(s): Morten A. Karsdal, Kim Henriksen, Mette Juul Nielsen, Inger Byrjalsen, Diana J. Leeming, Stephen Gardner, Zachary Goodman, Keyur Patel, Aleksander Krag, Claus Christiansen, Detlef Schuppan
Published in: American Journal of Physiology-Gastrointestinal and Liver Physiology, 311/6, 2016, Page(s) G1009-G1017, ISSN 0193-1857
Publisher: American Physiological Society
DOI: 10.1152/ajpgi.00283.2016

MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals

Author(s): Benedetta Donati, Paola Dongiovanni, Stefano Romeo, Marica Meroni, Misti McCain, Luca Miele, Salvatore Petta, Silvia Maier, Chiara Rosso, Laura De Luca, Ester Vanni, Stefania Grimaudo, Renato Romagnoli, Fabio Colli, Flaminia Ferri, Rosellina Margherita Mancina, Paula Iruzubieta, Antonio Craxi, Anna Ludovica Fracanzani, Antonio Grieco, Stefano Ginanni Corradini, Alessio Aghemo, Massimo Colombo, Gio
Published in: Scientific Reports, 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-04991-0

NAFLD: PNPLA3 and obesity: a synergistic relationship in NAFLD

Author(s): Jake P. Mann, Quentin M. Anstee
Published in: Nature Reviews Gastroenterology & Hepatology, 14/9, 2017, Page(s) 506-507, ISSN 1759-5045
Publisher: Nature Publishing Group
DOI: 10.1038/nrgastro.2017.74

Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis

Author(s): Stuart McPherson, Tim Hardy, Jean-Francois Dufour, Salvatore Petta, Manuel Romero-Gomez, Mike Allison, Claudia P Oliveira, Sven Francque, Luc Van Gaal, Jörn M Schattenberg, Dina Tiniakos, Alastair Burt, Elisabetta Bugianesi, Vlad Ratziu, Christopher P Day, Quentin M Anstee
Published in: The American Journal of Gastroenterology, 112/5, 2016, Page(s) 740-751, ISSN 0002-9270
Publisher: Blackwell Publishing Inc.
DOI: 10.1038/ajg.2016.453

Serum lipidomics reveals early differential effects of gastric bypass compared with banding on phospholipids and sphingolipids independent of differences in weight loss

Author(s): B D Kayser, M Lhomme, M C Dao, F Ichou, J-L Bouillot, E Prifti, A Kontush, J-M Chevallier, J Aron-Wisnewsky, I Dugail, K Clément
Published in: International Journal of Obesity, 41/6, 2017, Page(s) 917-925, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/ijo.2017.63

Definitions of Normal Liver Fat and the Association of Insulin Sensitivity with Acquired and Genetic NAFLD—A Systematic Review

Author(s): Elina Petäjä, Hannele Yki-Järvinen
Published in: International Journal of Molecular Sciences, 17/5, 2016, Page(s) 633, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms17050633

Glucose kinetics

Author(s): Amalia Gastaldelli, Melania Gaggini, Ralph DeFronzo
Published in: Current Opinion in Clinical Nutrition and Metabolic Care, 20/4, 2017, Page(s) 300-309, ISSN 1363-1950
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MCO.0000000000000384

The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans

Author(s): Panu K. Luukkonen, You Zhou, Tuulia Hyötyläinen, Marja Leivonen, Johanna Arola, Marju Orho-Melander, Matej Orešič, Hannele Yki-Järvinen
Published in: Journal of Hepatology, 65/6, 2016, Page(s) 1263-1265, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2016.07.045

Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans

Author(s): Panu K. Luukkonen, You Zhou, Elina Isokuortti, Marja Leivonen, Anne Juuti, Antti Hakkarainen, Marju Orho-Melander, Nina Lundbom, Vesa M. Olkkonen, Riitta Lassila, Hannele Yki-Järvinen, Susanna Lallukka
Published in: Thrombosis and Haemostasis, 117/02, 2017, Page(s) 286-294, ISSN 0340-6245
Publisher: Schattauer
DOI: 10.1160/TH16-09-0716

Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases

Author(s): Leon A Adams, Quentin M Anstee, Herbert Tilg, Giovanni Targher
Published in: Gut, 66/6, 2017, Page(s) 1138-1153, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2017-313884

Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease

Author(s): Zoe Hall, Nicholas J. Bond, Tom Ashmore, Francis Sanders, Zsuzsanna Ament, Xinzhu Wang, Andrew J. Murray, Elena Bellafante, Sam Virtue, Antonio Vidal-Puig, Michael Allison, Susan E. Davies, Albert Koulman, Michele Vacca, Julian L. Griffin
Published in: Hepatology, 65/4, 2017, Page(s) 1165-1180, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.28953

Use of HOMA-IR to diagnose non-alcoholic fatty liver disease: a population-based and inter-laboratory study

Author(s): Elina Isokuortti, You Zhou, Markku Peltonen, Elisabetta Bugianesi, Karine Clement, Dominique Bonnefont-Rousselot, Jean-Marc Lacorte, Amalia Gastaldelli, Detlef Schuppan, Jörn M. Schattenberg, Antti Hakkarainen, Nina Lundbom, Pekka Jousilahti, Satu Männistö, Sirkka Keinänen-Kiukaanniemi, Juha Saltevo, Quentin M. Anstee, Hannele Yki-Järvinen
Published in: Diabetologia, 60/10, 2017, Page(s) 1873-1882, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-017-4340-1

Role of Adipose Tissue Insulin Resistance in the Natural History of Type 2 Diabetes: Results From the San Antonio Metabolism Study

Author(s): Amalia Gastaldelli, Melania Gaggini, Ralph A. DeFronzo
Published in: Diabetes, 66/4, 2017, Page(s) 815-822, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db16-1167

Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD

Author(s): Panu K. Luukkonen, You Zhou, P.A. Nidhina Haridas, Om P. Dwivedi, Tuulia Hyötyläinen, Ashfaq Ali, Anne Juuti, Marja Leivonen, Taru Tukiainen, Linda Ahonen, Emma Scott, Jeremy M. Palmer, Johanna Arola, Marju Orho-Melander, Petter Vikman, Quentin M. Anstee, Vesa M. Olkkonen, Matej Orešič, Leif Groop, Hannele Yki-Järvinen
Published in: Journal of Hepatology, 67/1, 2017, Page(s) 128-136, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2017.02.014

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

Author(s): Shabnam Shalapour, Xue-Jia Lin, Ingmar N. Bastian, John Brain, Alastair D. Burt, Alexander A. Aksenov, Alison F. Vrbanac, Weihua Li, Andres Perkins, Takaji Matsutani, Zhenyu Zhong, Debanjan Dhar, Jose A. Navas-Molina, Jun Xu, Rohit Loomba, Michael Downes, Ruth T. Yu, Ronald M. Evans, Pieter C. Dorrestein, Rob Knight, Christopher Benner, Quentin M. Anstee, Michael Karin
Published in: Nature, 551/7680, 2017, Page(s) 340-345, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature24302

Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance

Author(s): Melania Gaggini, Fabrizia Carli, Chiara Rosso, Emma Buzzigoli, Milena Marietti, Veronica Della Latta, Demetrio Ciociaro, Maria Lorena Abate, Roberto Gambino, Maurizio Cassader, Elisabetta Bugianesi, Amalia Gastaldelli
Published in: Hepatology, 67/1, 2018, Page(s) 145-158, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.29465

The good and the bad collagens of fibrosis – Their role in signaling and organ function

Author(s): M.A. Karsdal, S.H. Nielsen, D.J. Leeming, L.L. Langholm, M.J. Nielsen, T. Manon-Jensen, A. Siebuhr, N.S. Gudmann, S. Rønnow, J.M. Sand, S.J. Daniels, J.H. Mortensen, D. Schuppan
Published in: Advanced Drug Delivery Reviews, 121, 2017, Page(s) 43-56, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2017.07.014

Should we undertake surveillance for HCC in patients with NAFLD?

Author(s): Ramy Younes, Elisabetta Bugianesi
Published in: Journal of Hepatology, 68/2, 2018, Page(s) 326-334, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2017.10.006

The bidirectional impacts of alcohol consumption and the metabolic syndrome: Cofactors for progressive fatty liver disease

Author(s): Marie Boyle, Steven Masson, Quentin M. Anstee
Published in: Journal of Hepatology, 68/2, 2018, Page(s) 251-267, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2017.11.006

Hypoxia-inducible factor 2α drives nonalcoholic fatty liver progression by triggering hepatocyte release of histidine-rich glycoprotein

Author(s): Elisabetta Morello, Salvatore Sutti, Beatrice Foglia, Erica Novo, Stefania Cannito, Claudia Bocca, Martina Rajsky, Stefania Bruzzì, Maria Lorena Abate, Chiara Rosso, Cristina Bozzola, Ezio David, Elisabetta Bugianesi, Emanuele Albano, Maurizio Parola
Published in: Hepatology, 67/6, 2018, Page(s) 2196-2214, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.29754

Determinants of fibrosis progression and regression in NASH

Author(s): Detlef Schuppan, Rambabu Surabattula, Xiao Yu Wang
Published in: Journal of Hepatology, 68/2, 2018, Page(s) 238-250, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2017.11.012

Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) – an 11-Year Prospective Study

Author(s): Susanna Lallukka, Sanja Sädevirta, Markus T. Kallio, Panu K. Luukkonen, You Zhou, Antti Hakkarainen, Nina Lundbom, Marju Orho-Melander, Hannele Yki-Järvinen
Published in: Scientific Reports, 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-14706-0

Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD

Author(s): Michael Allison, Julian Griffin, Michele Vacca, Antonio Vidal-Puig
Published in: Seminars in Liver Disease, 35/03, 2015, Page(s) 250-261, ISSN 0272-8087
Publisher: Thieme Medical Publishers
DOI: 10.1055/s-0035-1562945

Genetic Factors That Affect Risk of Alcoholic and Nonalcoholic Fatty Liver Disease

Author(s): Quentin M. Anstee, Devanshi Seth, Christopher P. Day
Published in: Gastroenterology, 150/8, 2016, Page(s) 1728-1744.e7, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2016.01.037

Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease

Author(s): Timothy Hardy, Mujdat Zeybel, Christopher P Day, Christian Dipper, Steven Masson, Stuart McPherson, Elsbeth Henderson, Dina Tiniakos, Steve White, Jeremy French, Derek A Mann, Quentin M Anstee, Jelena Mann
Published in: Gut, 0, 1-8, 2016, Page(s) gutjnl-2016-311526, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2016-311526

Review article: emerging anti-fibrotic therapies in the treatment of non-alcoholic steatohepatitis

Author(s): M. Noureddin, Q. M. Anstee, R. Loomba
Published in: Alimentary Pharmacology & Therapeutics, 43/11, 2016, Page(s) 1109-1123, ISSN 0269-2813
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/apt.13620

The Genetics of Nonalcoholic Fatty Liver Disease: Spotlight on PNPLA3 and TM6SF2

Author(s): Christopher Day, Quentin Anstee
Published in: Seminars in Liver Disease, 35/03, 2015, Page(s) 270-290, ISSN 0272-8087
Publisher: Thieme Medical Publishers
DOI: 10.1055/s-0035-1562947

Serum endotrophin identifies optimal responders to PPARγ agonists in type 2 diabetes

Author(s): Morten A. Karsdal, Kim Henriksen, Federica Genovese, Diana J. Leeming, Mette J. Nielsen, Bente J. Riis, Claus Christiansen, Inger Byrjalsen, Detlef Schuppan
Published in: Diabetologia, 60/1, 2017, Page(s) 50-59, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-016-4094-1

Genetics of Alcoholic Liver Disease

Author(s): Ann Daly, Christopher Day, Quentin Anstee
Published in: Seminars in Liver Disease, 35/04, 2015, Page(s) 361-374, ISSN 0272-8087
Publisher: Thieme Medical Publishers
DOI: 10.1055/s-0035-1567832

Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum

Author(s): Timothy Hardy, Fiona Oakley, Quentin M. Anstee, Christopher P. Day
Published in: Annual Review of Pathology: Mechanisms of Disease, 11/1, 2016, Page(s) 451-496, ISSN 1553-4006
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-pathol-012615-044224

Peripheral insulin resistance predicts liver damage in nondiabetic subjects with nonalcoholic fatty liver disease

Author(s): Chiara Rosso, Lavinia Mezzabotta, Melania Gaggini, Federico Salomone, Roberto Gambino, Andrea Marengo, Francesca Saba, Ester Vanni, Rami I.K. Jouness, Chiara Saponaro, Emma Buzzigoli, Gian Paolo Caviglia, Maria Lorena Abate, Antonina Smedile, Mario Rizzetto, Maurizio Cassader, Amalia Gastaldelli, Elisabetta Bugianesi
Published in: Hepatology, 63/1, 2016, Page(s) 107-116, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.28287

Systematic review of bariatric surgery liver biopsies clarifies the natural history of liver disease in patients with severe obesity

Author(s): Pierre Bedossa, Joan Tordjman, Judith Aron-Wisnewsky, Christine Poitou, Jean-Michel Oppert, Adriana Torcivia, Jean-Luc Bouillot, Valerie Paradis, Vlad Ratziu, Karine Clément
Published in: Gut, 66/9, 2017, Page(s) 1688-1696, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2016-312238

Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars

Author(s): Panu K. Luukkonen, Sanja Sädevirta, You Zhou, Brandon Kayser, Ashfaq Ali, Linda Ahonen, Susanna Lallukka, Véronique Pelloux, Melania Gaggini, Ching Jian, Antti Hakkarainen, Nina Lundbom, Helena Gylling, Anne Salonen, Matej Orešič, Tuulia Hyötyläinen, Marju Orho-Melander, Aila Rissanen, Amalia Gastaldelli, Karine Clément, Leanne Hodson, Hannele Yki-Järvinen
Published in: Diabetes Care, 41/8, 2018, Page(s) 1732-1739, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dc18-0071

Genetics of alcoholic liver disease and non-alcoholic steatohepatitis

Author(s): Emma Scott, Quentin M Anstee
Published in: Clinical Medicine, 18/Suppl 2, 2018, Page(s) s54-s59, ISSN 1470-2118
Publisher: Royal College of Physicians
DOI: 10.7861/clinmedicine.18-2-s54

Liver fibrosis: Direct antifibrotic agents and targeted therapies

Author(s): Detlef Schuppan, Muhammad Ashfaq-Khan, Ai Ting Yang, Yong Ook Kim
Published in: Matrix Biology, 68-69, 2018, Page(s) 435-451, ISSN 0945-053X
Publisher: Elsevier BV
DOI: 10.1016/j.matbio.2018.04.006

Fibrosis and alcohol-related liver disease

Author(s): Carolin Lackner, Dina Tiniakos
Published in: Journal of Hepatology, 70/2, 2019, Page(s) 294-304, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2018.12.003

A spotlight on pathogenesis, interactions and novel therapeutic options in NAFLD

Author(s): Ramy Younes, Elisabetta Bugianesi
Published in: Nature Reviews Gastroenterology & Hepatology, 16/2, 2019, Page(s) 80-82, ISSN 1759-5045
Publisher: Nature Publishing Group
DOI: 10.1038/s41575-018-0094-6

P465L-PPARγ mutation confers partial resistance to the hypolipidaemic action of fibrates

Author(s): Sergio Rodriguez-Cuenca, Stefania Carobbio, Gwendolyn Barceló-Coblijn, Xavier Prieur, Joana Relat, Ramon Amat, Mark Campbell, Ana Rita Dias, Myriam Bahri, Sarah L. Gray, Antonio Vidal-Puig
Published in: Diabetes, Obesity and Metabolism, 20/10, 2018, Page(s) 2339-2350, ISSN 1462-8902
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/dom.13370

The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Author(s): Konstantin Kazankov, Simon Mark Dahl Jørgensen, Karen Louise Thomsen, Holger Jon Møller, Hendrik Vilstrup, Jacob George, Detlef Schuppan, Henning Grønbæk
Published in: Nature Reviews Gastroenterology & Hepatology, 16/3, 2019, Page(s) 145-159, ISSN 1759-5045
Publisher: Nature Publishing Group
DOI: 10.1038/s41575-018-0082-x

Assessment of liver fibrosis progression and regression by a serological collagen turnover profile

Author(s): Morten A. Karsdal, Sara T. Hjuler, Yi Luo, Daniel G. K. Rasmussen, Mette J. Nielsen, Signe Holm Nielsen, Diana J. Leeming, Zachary Goodman, Robert H. Arch, Keyur Patel, Detlef Schuppan
Published in: American Journal of Physiology-Gastrointestinal and Liver Physiology, 316/1, 2019, Page(s) G25-G31, ISSN 0193-1857
Publisher: American Physiological Society
DOI: 10.1152/ajpgi.00158.2018

From NASH to HCC: current concepts and future challenges

Author(s): Quentin M. Anstee, Helen L. Reeves, Elena Kotsiliti, Olivier Govaere, Mathias Heikenwalder
Published in: Nature Reviews Gastroenterology & Hepatology, 16/7, 2019, Page(s) 411-428, ISSN 1759-5045
Publisher: Nature Publishing Group
DOI: 10.1038/s41575-019-0145-7

Mouse Models of Nonalcoholic Steatohepatitis: Toward Optimization of Their Relevance to Human Nonalcoholic Steatohepatitis

Author(s): Geoff Farrell, Jörn M. Schattenberg, Isabelle Leclercq, Matthew M. Yeh, Robert Goldin, Narci Teoh, Detlef Schuppan
Published in: Hepatology, 69/5, 2019, Page(s) 2241-2257, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.30333

Phosphatidylglycerols are induced by gut dysbiosis and inflammation, and favorably modulate adipose tissue remodeling in obesity

Author(s): Brandon D. Kayser, Marie Lhomme, Edi Prifti, Carla Da Cunha, Florian Marquet, Florian Chain, Isabelle Naas, Véronique Pelloux, Maria-Carlota Dao, Anatol Kontush, Salwa W. Rizkalla, Judith Aron-Wisnewsky, Luis G. Bermúdez-Humarán, Fiona Oakley, Philippe Langella, Karine Clément, Isabelle Dugail
Published in: The FASEB Journal, 33/4, 2019, Page(s) 4741-4754, ISSN 0892-6638
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201801897r

Improvement of non-invasive markers of NAFLD from an individualised, web-based exercise program

Author(s): Yvonne Huber, Daniel Pfirrmann, Ines Gebhardt, Christian Labenz, Nadine Gehrke, Beate K. Straub, Christian Ruckes, Heike Bantel, Eugenio Belda, Karine Clément, Diana J. Leeming, Morten A. Karsdal, Peter R. Galle, Perikles Simon, Jörn M. Schattenberg
Published in: Alimentary Pharmacology & Therapeutics, 50/8, 2019, Page(s) 930-939, ISSN 0269-2813
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/apt.15427

qFIBS: A Novel Automated Technique for Quantitative Evaluation of Fibrosis, Inflammation, Ballooning, and Steatosis in Patients With Nonalcoholic Steatohepatitis

Author(s): Feng Liu, George Boon‐Bee Goh, Dina Tiniakos, Aileen Wee, Wei‐Qiang Leow, Jing‐Min Zhao, Hui‐Ying Rao, Xiao‐Xiao Wang, Qin Wang, Wei‐Keat Wan, Kiat‐Hon Lim, Manuel Romero‐Gomez, Salvatore Petta, Elisabetta Bugianesi, Chee‐Kiat Tan, Stephen A. Harrison, Quentin M. Anstee, Pik‐Eu Jason Chang, Lai Wei
Published in: Hepatology, 2019, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.30986

Lipidomes in health and disease: Analytical strategies and considerations

Author(s): Fang Wei, Santosh Lamichhane, Matej Orešič, Tuulia Hyötyläinen
Published in: TrAC Trends in Analytical Chemistry, 120, 2019, Page(s) 115664, ISSN 0165-9936
Publisher: Elsevier BV
DOI: 10.1016/j.trac.2019.115664

Performance of the PRO-C3 collagen neo-epitope biomarker in non-alcoholic fatty liver disease

Author(s): Marie Boyle, Dina Tiniakos, Jorn M. Schattenberg, Vlad Ratziu, Elisabetta Bugianessi, Salvatore Petta, Claudia P. Oliveira, Olivier Govaere, Ramy Younes, Stuart McPherson, Pierre Bedossa, Mette J Nielsen, Morten Karsdal, Diana Leeming, Stuart Kendrick, Quentin M. Anstee
Published in: JHEP Reports, 1/3, 2019, Page(s) 188-198, ISSN 2589-5559
Publisher: Elsevier B.V.
DOI: 10.1016/j.jhepr.2019.06.004

Voluntary exercise in mice fed an obesogenic diet alters the hepatic immune phenotype and improves metabolic parameters – an animal model of life style intervention in NAFLD

Author(s): Nadine Gehrke, Jana Biedenbach, Yvonne Huber, Beate K. Straub, Peter R. Galle, Perikles Simon, Jörn M. Schattenberg
Published in: Scientific Reports, 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-38321-9

Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites

Author(s): You Zhou, Matej Orešič, Marja Leivonen, Peddinti Gopalacharyulu, Jenni Hyysalo, Johanna Arola, An Verrijken, Sven Francque, Luc Van Gaal, Tuulia Hyötyläinen, Hannele Yki-Järvinen
Published in: Clinical Gastroenterology and Hepatology, 14/10, 2016, Page(s) 1463-1472.e6, ISSN 1542-3565
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.cgh.2016.05.046

Heterogeneity of non-alcoholic fatty liver disease

Author(s): Hannele Yki-Järvinen, Panu K. Luukkonen
Published in: Liver International, 35/12, 2015, Page(s) 2498-2500, ISSN 1478-3223
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/liv.12970

Metabolic syndrome and severity of fibrosis in nonalcoholic fatty liver disease: An age-dependent risk profiling study

Author(s): Salvatore Petta, Mohammed Eslam, Luca Valenti, Elisabetta Bugianesi, Marco Barbara, Calogero Cammà, Marianna Porzio, Chiara Rosso, Silvia Fargion, Jacob George, Antonio Craxì
Published in: Liver International, 37/9, 2017, Page(s) 1389-1396, ISSN 1478-3223
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/liv.13397

Non-pharmacological interventions in non-alcoholic fatty liver disease patients

Author(s): Vlad Ratziu
Published in: Liver International, 37, 2017, Page(s) 90-96, ISSN 1478-3223
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/liv.13311

The impact of human activities and lifestyles on the interlinked microbiota and health of humans and of ecosystems

Author(s): Lucette Flandroy, Theofilos Poutahidis, Gabriele Berg, Gerard Clarke, Maria-Carlota Dao, Ellen Decaestecker, Eeva Furman, Tari Haahtela, Sébastien Massart, Hubert Plovier, Yolanda Sanz, Graham Rook
Published in: Science of The Total Environment, 627, 2018, Page(s) 1018-1038, ISSN 0048-9697
Publisher: Elsevier BV
DOI: 10.1016/j.scitotenv.2018.01.288

Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants

Author(s): Gemma F. Codner, Joffrey Mianné, Adam Caulder, Jorik Loeffler, Rachel Fell, Ruairidh King, Alasdair J. Allan, Matthew Mackenzie, Fran J. Pike, Christopher V. McCabe, Skevoulla Christou, Sam Joynson, Marie Hutchison, Michelle E. Stewart, Saumya Kumar, Michelle M. Simon, Loranne Agius, Quentin M. Anstee, Kirill E. Volynski, Dimitri M. Kullmann, Sara Wells, Lydia Teboul
Published in: BMC Biology, 16/1, 2018, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-018-0530-7

NASH in Lean Individuals

Author(s): Ramy Younes, Elisabetta Bugianesi
Published in: Seminars in Liver Disease, 39/01, 2019, Page(s) 086-095, ISSN 0272-8087
Publisher: Thieme Medical Publishers
DOI: 10.1055/s-0038-1677517

Metabolic Modeling of Human Gut Microbiota on a Genome Scale: An Overview

Author(s): Partho Sen, Matej Orešič
Published in: Metabolites, 9/2, 2019, Page(s) 22, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo9020022

From NASH to diabetes and from diabetes to NASH: Mechanisms and treatment options

Author(s): Amalia Gastaldelli, Kenneth Cusi
Published in: JHEP Reports, 1/4, 2019, Page(s) 312-328, ISSN 2589-5559
Publisher: Elsevier
DOI: 10.1016/j.jhepr.2019.07.002

Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis

Author(s): Olivier Govaere, Simon Cockell, Dina Tiniakos, Rachel Queen, Ramy Younes, Michele Vacca, Leigh Alexander, Federico Ravaioli, Jeremy Palmer, Salvatore Petta, Jerome Boursier, Chiara Rosso, Katherine Johnson, Kristy Wonders, Christopher P. Day, Mattias Ekstedt, Matej Orešič, Rebecca Darlay, Heather J. Cordell, Fabio Marra, Antonio Vidal-Puig, Pierre Bedossa, Jörn M. Schattenberg, Karine Clément,
Published in: Science Translational Medicine, 12/572, 2020, Page(s) eaba4448, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aba4448

Editorial: hepatocellular carcinoma in non-cirrhotic NASH-a troubling reality

Author(s): Marie Boyle, Quentin M. Anstee
Published in: Alimentary Pharmacology & Therapeutics, 48/9, 2018, Page(s) 1021-1023, ISSN 0269-2813
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/apt.14982

Editorial: collagen proportionate area as a prognostic indicator in NAFLD

Author(s): Federico Ravaioli, Quentin M. Anstee
Published in: Alimentary Pharmacology & Therapeutics, 49/11, 2019, Page(s) 1452-1454, ISSN 0269-2813
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/apt.15249

Bile acids composition modulate insulin resistance in non-diabetic patients with NAFLD

Author(s): Rosso, C.; Younes, R.; Eslam, M.; Chen, Fw.; Cucco, M.; Gaggini, M.; Coulter, S.; Carli, F.; Barbieri, C.; della Latta, V.; Abate, M. L.; Saracco, Gm.; Gastaldelli, A.; George, J.; Bugianesi, E.
Published in: 21, 2018
Publisher: Elsevier Inc.

Predisposition to diabetes is related to insulin resistance in NAFLD patients and to decreased insulin secretion in HCV patients

Author(s): Pierantonelli, G. Svegliati-Baroni I.; Younes, R.; Rosso, C.; Rychlicki, C.; Bugianesi, E.; Gastaldelli, A.
Published in: 5, 2018
Publisher: Elsevier Inc.

In non obese NAFLD increased plasma saturated fatty acids and insulin resistance are metabolic signatures of severity of liver disease

Author(s): Carli, F.; Gaggini, M.; Rosso, C.; Saponaro, C.; Barbieri, C.; Latta, V. D.; Buzzigoli, E.; Ciociaro, D.; Abate, M. L.; Marietti, M.; Younes, R.; Bugianesi, E.; Gastaldelli, A.
Published in: 8, 2018
Publisher: Elsevier Inc.

Hepatic macrophage activation is associated with adipose tissue insulin resistance in non-diabetic patients with Non-Alcoholic Fatty Liver Disease

Author(s): Rosso, Chiara; Kazankov, K.; Marietti, Milena; Gaggini, M.; Buzzigoli, E.; Møller, H. J.; Caviglia, GIAN PAOLO; Abate, Maria Lorena; Smedile, Antonina; Saracco, Giorgio Maria; Vilstrup, H.; Gastaldelli, A.; George, J.; Grønbæk, H.; Bugianesi, Elisabetta
Published in: 12, 2016
Publisher: John Wiley & Sons, Inc.

Plasma Selenoprotein P levels are related to adipose tissue insulin resistance, composition of free fatty acids and liver fibrosis in non-diabetic patients with Non Alcoholic Fatty Liver Disease

Author(s): Rosso, Chiara; Younes, Ramy; Fabrizia, Carli; Melania, Gaggini; Lavinia, Mezzabotta; Marietti, Milena; Federico, Salomone; Gambino, Roberto; Saba, Francesca; Emma, Buzzigoli; Demetrio, Ciociaro; Caviglia, GIAN PAOLO; Morello, Elisabetta; Abate, Maria Lorena; Smedile, Antonina; Ciancio, Alessia; Cassader, Maurizio; Saracco, Giorgio Maria; Amalia, Gastaldelli; Bugianesi, Elisabetta
Published in: 9, 2017
Publisher: John Wiey & Sons, Inc.

Insulin secretion and decreased glucose clearance are associated with enhanced fibrogenesis and a high risk of disease progression in non-diabetic patients with Non Alcoholic Fatty Liver Disease

Author(s): Younes, Ramy; Rosso, Chiara; Melania, Gaggini; Lavinia, Mezzabotta; Marietti, Milena; Fabrizia, Carli; Federico, Salomone; Emma, Buzzigoli; Caviglia, GIAN PAOLO; Chiara, Barbieri; Abate, Maria Lorena; Smedile, Antonina; Saracco, Giorgio Maria; Anstee, Quentin M.; Leeming, Diana J.; Amalia, Gastaldelli; Detlef, Schuppan; Bugianesi, Elisabetta
Published in: 9, 2017
Publisher: John Wiley & Sons, Inc.

Hepatocellular carcinoma and metabolic risk factors in a main reference center in Italy

Author(s): Younes, R; Rosso, C; Marietti, M; Caviglia, Gp; Nascè, A; Campion, D; Cantamessa, A; Carucci, P; Bugianesi, E
Published in: 9, 2017
Publisher: Elsevier Inc.