Deliverables Documents, reports (5) Detailed dissemination plan Detailed dissemination plan Final reports summarising recruitment into the EPoS database, biobanked samples availability, and longitudinal outcome studies Final reports summarising recruitment into the EPoS database, biobanked samples availability, and longitudinal outcome studies Report on data management plan for the EPoS project Report on data management plan for the EPoS project Project Handbook Project Handbook Risk assessment procedure Risk assessment procedure Publications Peer reviewed articles (74) Relationship Among Fatty Liver, Specific and Multiple‐Site Atherosclerosis, and 10‐Year Framingham Score Author(s): Raluca Pais, Alban Redheuil, Philippe Cluzel, Vlad Ratziu, Philippe Giral Published in: Hepatology, Issue 69/4, 2019, Page(s) 1453-1463, ISSN 0270-9139 Publisher: John Wiley & Sons Inc. DOI: 10.1002/hep.30223 Health-related Quality of Life in Nonalcoholic Fatty Liver Disease Associates With Hepatic Inflammation Author(s): Yvonne Huber, Marie Boyle, Kate Hallsworth, Dina Tiniakos, Beate K. Straub, Christian Labenz, Christian Ruckes, Peter R. Galle, Manuel Romero-Gómez, Quentin M. Anstee, Jörn M. Schattenberg Published in: Clinical Gastroenterology and Hepatology, Issue 17/10, 2019, Page(s) 2085-2092.e1, ISSN 1542-3565 Publisher: W. B. Saunders Co., Ltd. DOI: 10.1016/j.cgh.2018.12.016 Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders Author(s): Judith Aron-Wisnewsky, Chloé Vigliotti, Julia Witjes, Phuong Le, Adriaan G. Holleboom, Joanne Verheij, Max Nieuwdorp, Karine Clément Published in: Nature Reviews Gastroenterology & Hepatology, Issue 17/5, 2020, Page(s) 279-297, ISSN 1759-5045 Publisher: Nature Publishing Group DOI: 10.1038/s41575-020-0269-9 Usefulness of the index of NASH - ION for the diagnosis of steatohepatitis in patients with non-alcoholic fatty liver: An external validation study Author(s): Ramy Younes, Chiara Rosso, Salvatore Petta, Monica Cucco, Milena Marietti, Gian Paolo Caviglia, Alessia Ciancio, Maria Lorena Abate, Carlo Cammà, Antonina Smedile, Antonio Craxì, Giorgio Maria Saracco, Elisabetta Bugianesi Published in: Liver International, Issue 38/4, 2018, Page(s) 715-723, ISSN 1478-3223 Publisher: Blackwell Publishing Inc. DOI: 10.1111/liv.13612 Predictors of advanced fibrosis in non-cirrhotic non-alcoholic fatty liver disease in Germany Author(s): Christian Labenz, Yvonne Huber, Eva Kalliga, Michael Nagel, Christian Ruckes, Beate K. Straub, Peter R. Galle, Marcus-Alexander Wörns, Quentin M. Anstee, Detlef Schuppan, Jörn M. Schattenberg Published in: Alimentary Pharmacology & Therapeutics, Issue 48/10, 2018, Page(s) 1109-1116, ISSN 0269-2813 Publisher: Blackwell Publishing Inc. DOI: 10.1111/apt.14976 Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort☆ Author(s): Quentin M. Anstee, Rebecca Darlay, Simon Cockell, Marica Meroni, Olivier Govaere, Dina Tiniakos, Alastair D. Burt, Pierre Bedossa, Jeremy Palmer, Yang-Lin Liu, Guruprasad P. Aithal, Michael Allison, Hannele Yki-Järvinen, Michele Vacca, Jean-Francois Dufour, Pietro Invernizzi, Daniele Prati, Mattias Ekstedt, Stergios Kechagias, Sven Francque, Salvatore Petta, Elisabetta Bugianesi, Karine Clement, Published in: Journal of Hepatology, Issue 73/3, 2020, Page(s) 505-515, ISSN 0168-8278 Publisher: Elsevier BV DOI: 10.1016/j.jhep.2020.04.003 Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular Carcinoma Author(s): Zoe Hall, Davide Chiarugi, Evelina Charidemou, Jack Leslie, Emma Scott, Luca Pellegrinet, Michael Allison, Gabriele Mocciaro, Quentin M. Anstee, Gerard I. Evan, Matthew Hoare, Antonio Vidal‐Puig, Fiona Oakley, Michele Vacca, Julian L. Griffin Published in: Hepatology, Issue 73/3, 2021, Page(s) 1028-1044, ISSN 0270-9139 Publisher: John Wiley & Sons Inc. DOI: 10.1002/hep.31391 Caucasian lean subjects with non-alcoholic fatty liver disease share long-term prognosis of non-lean: time for reappraisal of BMI-driven approach? Author(s): Ramy Younes, Olivier Govaere, Salvatore Petta, Luca Miele, Dina Tiniakos, Alastair Burt, Ezio David, Fabio Maria Vecchio, Marco Maggioni, Daniela Cabibi, Duncan McLeod, Maria Jesus Pareja, Anna Ludovica Fracanzani, Rocio Aller, Chiara Rosso, Javier Ampuero, Rocío Gallego-Durán, Angelo Armandi, Gian Paolo Caviglia, Marco Y W Zaki, Antonio Liguori, Paolo Francione, Grazia Pennisi, Antonio Grieco, Published in: Gut, 2021, Page(s) gutjnl-2020-322564, ISSN 0017-5749 Publisher: BMJ Publishing Group DOI: 10.1136/gutjnl-2020-322564 Clinical implications of hepatic progenitor cell activation in non-alcoholic fatty liver disease Author(s): Ramy Younes, Rachel Burgoyne, Dina Tiniakos, Olivier Govaere Published in: Hepatoma Research, Issue 2021, 2021, ISSN 2454-2520 Publisher: - DOI: 10.20517/2394-5079.2020.119 Quantitative PCR provides a simple and accessible method for quantitative microbiota profiling Author(s): Ching Jian, Panu Luukkonen, Hannele Yki-Järvinen, Anne Salonen, Katri Korpela Published in: PLOS ONE, Issue 15/1, 2020, Page(s) e0227285, ISSN 1932-6203 Publisher: Public Library of Science DOI: 10.1371/journal.pone.0227285 Elevated serum ceramides are linked with obesity-associated gut dysbiosis and impaired glucose metabolism Author(s): Brandon D. Kayser, Edi Prifti, Marie Lhomme, Eugeni Belda, Maria-Carlota Dao, Judith Aron-Wisnewsky, Anatol Kontush, Jean-Daniel Zucker, Salwa W. Rizkalla, Isabelle Dugail, Karine Clément Published in: Metabolomics, Issue 15/11, 2019, ISSN 1573-3882 Publisher: Springer Verlag DOI: 10.1007/s11306-019-1596-0 Interplay between metabolic derangement, hepatic fibrogenesis and macrophage activation in non-diabetic patients with non-alcoholic fatty liver disease Author(s): C. Rosso, R. Younes, D.J. Leeming, R. Surabattula, G.P. Caviglia, M. Gaggini, A. Armandi, A. Olivero, M.L. Abate, A. Gastaldelli, D. Schuppan, E. Bugianesi Published in: Digestive and Liver Disease, Issue 52, 2020, Page(s) e10, ISSN 1590-8658 Publisher: W. B. Saunders Co., Ltd. DOI: 10.1016/j.dld.2019.12.025 Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease Author(s): Tuulia Hyötyläinen, Livnat Jerby, Elina M. Petäjä, Ismo Mattila, Sirkku Jäntti, Petri Auvinen, Amalia Gastaldelli, Hannele Yki-Järvinen, Eytan Ruppin, Matej Orešič Published in: Nature Communications, Issue 7, 2016, Page(s) 8994, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/ncomms9994 Nutritional Modulation of Non-Alcoholic Fatty Liver Disease and Insulin Resistance Author(s): Hannele Yki-Järvinen Published in: Nutrients, Issue 7/11, 2015, Page(s) 9127-9138, ISSN 2072-6643 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/nu7115454 Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention Author(s): Zobair Younossi, Quentin M. Anstee, Milena Marietti, Timothy Hardy, Linda Henry, Mohammed Eslam, Jacob George, Elisabetta Bugianesi Published in: Nature Reviews Gastroenterology & Hepatology, Issue 15/1, 2017, Page(s) 11-20, ISSN 1759-5045 Publisher: Nature Publishing Group DOI: 10.1038/nrgastro.2017.109 Phosphorylated IGFBP-1 as a non-invasive predictor of liver fat in NAFLD Author(s): Elina M. Petäjä, You Zhou, Marika Havana, Antti Hakkarainen, Nina Lundbom, Jarkko Ihalainen, Hannele Yki-Järvinen Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/srep24740 Fibrogenesis assessed by serological type III collagen formation identifies patients with progressive liver fibrosis and responders to a potential antifibrotic therapy Author(s): Morten A. Karsdal, Kim Henriksen, Mette Juul Nielsen, Inger Byrjalsen, Diana J. Leeming, Stephen Gardner, Zachary Goodman, Keyur Patel, Aleksander Krag, Claus Christiansen, Detlef Schuppan Published in: American Journal of Physiology-Gastrointestinal and Liver Physiology, Issue 311/6, 2016, Page(s) G1009-G1017, ISSN 0193-1857 Publisher: American Physiological Society DOI: 10.1152/ajpgi.00283.2016 MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals Author(s): Benedetta Donati, Paola Dongiovanni, Stefano Romeo, Marica Meroni, Misti McCain, Luca Miele, Salvatore Petta, Silvia Maier, Chiara Rosso, Laura De Luca, Ester Vanni, Stefania Grimaudo, Renato Romagnoli, Fabio Colli, Flaminia Ferri, Rosellina Margherita Mancina, Paula Iruzubieta, Antonio Craxi, Anna Ludovica Fracanzani, Antonio Grieco, Stefano Ginanni Corradini, Alessio Aghemo, Massimo Colombo, Gio Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-017-04991-0 NAFLD: PNPLA3 and obesity: a synergistic relationship in NAFLD Author(s): Jake P. Mann, Quentin M. Anstee Published in: Nature Reviews Gastroenterology & Hepatology, Issue 14/9, 2017, Page(s) 506-507, ISSN 1759-5045 Publisher: Nature Publishing Group DOI: 10.1038/nrgastro.2017.74 Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis Author(s): Stuart McPherson, Tim Hardy, Jean-Francois Dufour, Salvatore Petta, Manuel Romero-Gomez, Mike Allison, Claudia P Oliveira, Sven Francque, Luc Van Gaal, Jörn M Schattenberg, Dina Tiniakos, Alastair Burt, Elisabetta Bugianesi, Vlad Ratziu, Christopher P Day, Quentin M Anstee Published in: The American Journal of Gastroenterology, Issue 112/5, 2016, Page(s) 740-751, ISSN 0002-9270 Publisher: Blackwell Publishing Inc. DOI: 10.1038/ajg.2016.453 Serum lipidomics reveals early differential effects of gastric bypass compared with banding on phospholipids and sphingolipids independent of differences in weight loss Author(s): B D Kayser, M Lhomme, M C Dao, F Ichou, J-L Bouillot, E Prifti, A Kontush, J-M Chevallier, J Aron-Wisnewsky, I Dugail, K Clément Published in: International Journal of Obesity, Issue 41/6, 2017, Page(s) 917-925, ISSN 0307-0565 Publisher: Nature Publishing Group DOI: 10.1038/ijo.2017.63 Definitions of Normal Liver Fat and the Association of Insulin Sensitivity with Acquired and Genetic NAFLD—A Systematic Review Author(s): Elina Petäjä, Hannele Yki-Järvinen Published in: International Journal of Molecular Sciences, Issue 17/5, 2016, Page(s) 633, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms17050633 Glucose kinetics Author(s): Amalia Gastaldelli, Melania Gaggini, Ralph DeFronzo Published in: Current Opinion in Clinical Nutrition and Metabolic Care, Issue 20/4, 2017, Page(s) 300-309, ISSN 1363-1950 Publisher: Lippincott Williams & Wilkins Ltd. DOI: 10.1097/MCO.0000000000000384 The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans Author(s): Panu K. Luukkonen, You Zhou, Tuulia Hyötyläinen, Marja Leivonen, Johanna Arola, Marju Orho-Melander, Matej Orešič, Hannele Yki-Järvinen Published in: Journal of Hepatology, Issue 65/6, 2016, Page(s) 1263-1265, ISSN 0168-8278 Publisher: Elsevier BV DOI: 10.1016/j.jhep.2016.07.045 Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans Author(s): Panu K. Luukkonen, You Zhou, Elina Isokuortti, Marja Leivonen, Anne Juuti, Antti Hakkarainen, Marju Orho-Melander, Nina Lundbom, Vesa M. Olkkonen, Riitta Lassila, Hannele Yki-Järvinen, Susanna Lallukka Published in: Thrombosis and Haemostasis, Issue 117/02, 2017, Page(s) 286-294, ISSN 0340-6245 Publisher: Schattauer DOI: 10.1160/TH16-09-0716 Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases Author(s): Leon A Adams, Quentin M Anstee, Herbert Tilg, Giovanni Targher Published in: Gut, Issue 66/6, 2017, Page(s) 1138-1153, ISSN 0017-5749 Publisher: BMJ Publishing Group DOI: 10.1136/gutjnl-2017-313884 Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease Author(s): Zoe Hall, Nicholas J. Bond, Tom Ashmore, Francis Sanders, Zsuzsanna Ament, Xinzhu Wang, Andrew J. Murray, Elena Bellafante, Sam Virtue, Antonio Vidal-Puig, Michael Allison, Susan E. Davies, Albert Koulman, Michele Vacca, Julian L. Griffin Published in: Hepatology, Issue 65/4, 2017, Page(s) 1165-1180, ISSN 0270-9139 Publisher: John Wiley & Sons Inc. DOI: 10.1002/hep.28953 Use of HOMA-IR to diagnose non-alcoholic fatty liver disease: a population-based and inter-laboratory study Author(s): Elina Isokuortti, You Zhou, Markku Peltonen, Elisabetta Bugianesi, Karine Clement, Dominique Bonnefont-Rousselot, Jean-Marc Lacorte, Amalia Gastaldelli, Detlef Schuppan, Jörn M. Schattenberg, Antti Hakkarainen, Nina Lundbom, Pekka Jousilahti, Satu Männistö, Sirkka Keinänen-Kiukaanniemi, Juha Saltevo, Quentin M. Anstee, Hannele Yki-Järvinen Published in: Diabetologia, Issue 60/10, 2017, Page(s) 1873-1882, ISSN 0012-186X Publisher: Springer Verlag DOI: 10.1007/s00125-017-4340-1 Role of Adipose Tissue Insulin Resistance in the Natural History of Type 2 Diabetes: Results From the San Antonio Metabolism Study Author(s): Amalia Gastaldelli, Melania Gaggini, Ralph A. DeFronzo Published in: Diabetes, Issue 66/4, 2017, Page(s) 815-822, ISSN 0012-1797 Publisher: American Diabetes Association DOI: 10.2337/db16-1167 Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD Author(s): Panu K. Luukkonen, You Zhou, P.A. Nidhina Haridas, Om P. Dwivedi, Tuulia Hyötyläinen, Ashfaq Ali, Anne Juuti, Marja Leivonen, Taru Tukiainen, Linda Ahonen, Emma Scott, Jeremy M. Palmer, Johanna Arola, Marju Orho-Melander, Petter Vikman, Quentin M. Anstee, Vesa M. Olkkonen, Matej Orešič, Leif Groop, Hannele Yki-Järvinen Published in: Journal of Hepatology, Issue 67/1, 2017, Page(s) 128-136, ISSN 0168-8278 Publisher: Elsevier BV DOI: 10.1016/j.jhep.2017.02.014 Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity Author(s): Shabnam Shalapour, Xue-Jia Lin, Ingmar N. Bastian, John Brain, Alastair D. Burt, Alexander A. Aksenov, Alison F. Vrbanac, Weihua Li, Andres Perkins, Takaji Matsutani, Zhenyu Zhong, Debanjan Dhar, Jose A. Navas-Molina, Jun Xu, Rohit Loomba, Michael Downes, Ruth T. Yu, Ronald M. Evans, Pieter C. Dorrestein, Rob Knight, Christopher Benner, Quentin M. Anstee, Michael Karin Published in: Nature, Issue 551/7680, 2017, Page(s) 340-345, ISSN 0028-0836 Publisher: Nature Publishing Group DOI: 10.1038/nature24302 Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance Author(s): Melania Gaggini, Fabrizia Carli, Chiara Rosso, Emma Buzzigoli, Milena Marietti, Veronica Della Latta, Demetrio Ciociaro, Maria Lorena Abate, Roberto Gambino, Maurizio Cassader, Elisabetta Bugianesi, Amalia Gastaldelli Published in: Hepatology, Issue 67/1, 2018, Page(s) 145-158, ISSN 0270-9139 Publisher: John Wiley & Sons Inc. DOI: 10.1002/hep.29465 The good and the bad collagens of fibrosis – Their role in signaling and organ function Author(s): M.A. Karsdal, S.H. Nielsen, D.J. Leeming, L.L. Langholm, M.J. Nielsen, T. Manon-Jensen, A. Siebuhr, N.S. Gudmann, S. Rønnow, J.M. Sand, S.J. Daniels, J.H. Mortensen, D. Schuppan Published in: Advanced Drug Delivery Reviews, Issue 121, 2017, Page(s) 43-56, ISSN 0169-409X Publisher: Elsevier BV DOI: 10.1016/j.addr.2017.07.014 Should we undertake surveillance for HCC in patients with NAFLD? Author(s): Ramy Younes, Elisabetta Bugianesi Published in: Journal of Hepatology, Issue 68/2, 2018, Page(s) 326-334, ISSN 0168-8278 Publisher: Elsevier BV DOI: 10.1016/j.jhep.2017.10.006 The bidirectional impacts of alcohol consumption and the metabolic syndrome: Cofactors for progressive fatty liver disease Author(s): Marie Boyle, Steven Masson, Quentin M. Anstee Published in: Journal of Hepatology, Issue 68/2, 2018, Page(s) 251-267, ISSN 0168-8278 Publisher: Elsevier BV DOI: 10.1016/j.jhep.2017.11.006 Hypoxia-inducible factor 2α drives nonalcoholic fatty liver progression by triggering hepatocyte release of histidine-rich glycoprotein Author(s): Elisabetta Morello, Salvatore Sutti, Beatrice Foglia, Erica Novo, Stefania Cannito, Claudia Bocca, Martina Rajsky, Stefania Bruzzì, Maria Lorena Abate, Chiara Rosso, Cristina Bozzola, Ezio David, Elisabetta Bugianesi, Emanuele Albano, Maurizio Parola Published in: Hepatology, Issue 67/6, 2018, Page(s) 2196-2214, ISSN 0270-9139 Publisher: John Wiley & Sons Inc. DOI: 10.1002/hep.29754 Determinants of fibrosis progression and regression in NASH Author(s): Detlef Schuppan, Rambabu Surabattula, Xiao Yu Wang Published in: Journal of Hepatology, Issue 68/2, 2018, Page(s) 238-250, ISSN 0168-8278 Publisher: Elsevier BV DOI: 10.1016/j.jhep.2017.11.012 Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) – an 11-Year Prospective Study Author(s): Susanna Lallukka, Sanja Sädevirta, Markus T. Kallio, Panu K. Luukkonen, You Zhou, Antti Hakkarainen, Nina Lundbom, Marju Orho-Melander, Hannele Yki-Järvinen Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-017-14706-0 Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD Author(s): Michael Allison, Julian Griffin, Michele Vacca, Antonio Vidal-Puig Published in: Seminars in Liver Disease, Issue 35/03, 2015, Page(s) 250-261, ISSN 0272-8087 Publisher: Thieme Medical Publishers DOI: 10.1055/s-0035-1562945 Genetic Factors That Affect Risk of Alcoholic and Nonalcoholic Fatty Liver Disease Author(s): Quentin M. Anstee, Devanshi Seth, Christopher P. Day Published in: Gastroenterology, Issue 150/8, 2016, Page(s) 1728-1744.e7, ISSN 0016-5085 Publisher: W. B. Saunders Co., Ltd. DOI: 10.1053/j.gastro.2016.01.037 Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease Author(s): Timothy Hardy, Mujdat Zeybel, Christopher P Day, Christian Dipper, Steven Masson, Stuart McPherson, Elsbeth Henderson, Dina Tiniakos, Steve White, Jeremy French, Derek A Mann, Quentin M Anstee, Jelena Mann Published in: Gut, Issue 0, 1-8, 2016, Page(s) gutjnl-2016-311526, ISSN 0017-5749 Publisher: BMJ Publishing Group DOI: 10.1136/gutjnl-2016-311526 Review article: emerging anti-fibrotic therapies in the treatment of non-alcoholic steatohepatitis Author(s): M. Noureddin, Q. M. Anstee, R. Loomba Published in: Alimentary Pharmacology & Therapeutics, Issue 43/11, 2016, Page(s) 1109-1123, ISSN 0269-2813 Publisher: Blackwell Publishing Inc. DOI: 10.1111/apt.13620 The Genetics of Nonalcoholic Fatty Liver Disease: Spotlight on PNPLA3 and TM6SF2 Author(s): Christopher Day, Quentin Anstee Published in: Seminars in Liver Disease, Issue 35/03, 2015, Page(s) 270-290, ISSN 0272-8087 Publisher: Thieme Medical Publishers DOI: 10.1055/s-0035-1562947 Serum endotrophin identifies optimal responders to PPARγ agonists in type 2 diabetes Author(s): Morten A. Karsdal, Kim Henriksen, Federica Genovese, Diana J. Leeming, Mette J. Nielsen, Bente J. Riis, Claus Christiansen, Inger Byrjalsen, Detlef Schuppan Published in: Diabetologia, Issue 60/1, 2017, Page(s) 50-59, ISSN 0012-186X Publisher: Springer Verlag DOI: 10.1007/s00125-016-4094-1 Genetics of Alcoholic Liver Disease Author(s): Ann Daly, Christopher Day, Quentin Anstee Published in: Seminars in Liver Disease, Issue 35/04, 2015, Page(s) 361-374, ISSN 0272-8087 Publisher: Thieme Medical Publishers DOI: 10.1055/s-0035-1567832 Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum Author(s): Timothy Hardy, Fiona Oakley, Quentin M. Anstee, Christopher P. Day Published in: Annual Review of Pathology: Mechanisms of Disease, Issue 11/1, 2016, Page(s) 451-496, ISSN 1553-4006 Publisher: Annual Reviews, Inc. DOI: 10.1146/annurev-pathol-012615-044224 Peripheral insulin resistance predicts liver damage in nondiabetic subjects with nonalcoholic fatty liver disease Author(s): Chiara Rosso, Lavinia Mezzabotta, Melania Gaggini, Federico Salomone, Roberto Gambino, Andrea Marengo, Francesca Saba, Ester Vanni, Rami I.K. Jouness, Chiara Saponaro, Emma Buzzigoli, Gian Paolo Caviglia, Maria Lorena Abate, Antonina Smedile, Mario Rizzetto, Maurizio Cassader, Amalia Gastaldelli, Elisabetta Bugianesi Published in: Hepatology, Issue 63/1, 2016, Page(s) 107-116, ISSN 0270-9139 Publisher: John Wiley & Sons Inc. DOI: 10.1002/hep.28287 Systematic review of bariatric surgery liver biopsies clarifies the natural history of liver disease in patients with severe obesity Author(s): Pierre Bedossa, Joan Tordjman, Judith Aron-Wisnewsky, Christine Poitou, Jean-Michel Oppert, Adriana Torcivia, Jean-Luc Bouillot, Valerie Paradis, Vlad Ratziu, Karine Clément Published in: Gut, Issue 66/9, 2017, Page(s) 1688-1696, ISSN 0017-5749 Publisher: BMJ Publishing Group DOI: 10.1136/gutjnl-2016-312238 Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars Author(s): Panu K. Luukkonen, Sanja Sädevirta, You Zhou, Brandon Kayser, Ashfaq Ali, Linda Ahonen, Susanna Lallukka, Véronique Pelloux, Melania Gaggini, Ching Jian, Antti Hakkarainen, Nina Lundbom, Helena Gylling, Anne Salonen, Matej Orešič, Tuulia Hyötyläinen, Marju Orho-Melander, Aila Rissanen, Amalia Gastaldelli, Karine Clément, Leanne Hodson, Hannele Yki-Järvinen Published in: Diabetes Care, Issue 41/8, 2018, Page(s) 1732-1739, ISSN 0149-5992 Publisher: American Diabetes Association DOI: 10.2337/dc18-0071 Genetics of alcoholic liver disease and non-alcoholic steatohepatitis Author(s): Emma Scott, Quentin M Anstee Published in: Clinical Medicine, Issue 18/Suppl 2, 2018, Page(s) s54-s59, ISSN 1470-2118 Publisher: Royal College of Physicians DOI: 10.7861/clinmedicine.18-2-s54 Liver fibrosis: Direct antifibrotic agents and targeted therapies Author(s): Detlef Schuppan, Muhammad Ashfaq-Khan, Ai Ting Yang, Yong Ook Kim Published in: Matrix Biology, Issue 68-69, 2018, Page(s) 435-451, ISSN 0945-053X Publisher: Elsevier BV DOI: 10.1016/j.matbio.2018.04.006 Fibrosis and alcohol-related liver disease Author(s): Carolin Lackner, Dina Tiniakos Published in: Journal of Hepatology, Issue 70/2, 2019, Page(s) 294-304, ISSN 0168-8278 Publisher: Elsevier BV DOI: 10.1016/j.jhep.2018.12.003 A spotlight on pathogenesis, interactions and novel therapeutic options in NAFLD Author(s): Ramy Younes, Elisabetta Bugianesi Published in: Nature Reviews Gastroenterology & Hepatology, Issue 16/2, 2019, Page(s) 80-82, ISSN 1759-5045 Publisher: Nature Publishing Group DOI: 10.1038/s41575-018-0094-6 P465L-PPARγ mutation confers partial resistance to the hypolipidaemic action of fibrates Author(s): Sergio Rodriguez-Cuenca, Stefania Carobbio, Gwendolyn Barceló-Coblijn, Xavier Prieur, Joana Relat, Ramon Amat, Mark Campbell, Ana Rita Dias, Myriam Bahri, Sarah L. Gray, Antonio Vidal-Puig Published in: Diabetes, Obesity and Metabolism, Issue 20/10, 2018, Page(s) 2339-2350, ISSN 1462-8902 Publisher: Blackwell Publishing Inc. DOI: 10.1111/dom.13370 The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis Author(s): Konstantin Kazankov, Simon Mark Dahl Jørgensen, Karen Louise Thomsen, Holger Jon Møller, Hendrik Vilstrup, Jacob George, Detlef Schuppan, Henning Grønbæk Published in: Nature Reviews Gastroenterology & Hepatology, Issue 16/3, 2019, Page(s) 145-159, ISSN 1759-5045 Publisher: Nature Publishing Group DOI: 10.1038/s41575-018-0082-x Assessment of liver fibrosis progression and regression by a serological collagen turnover profile Author(s): Morten A. Karsdal, Sara T. Hjuler, Yi Luo, Daniel G. K. Rasmussen, Mette J. Nielsen, Signe Holm Nielsen, Diana J. Leeming, Zachary Goodman, Robert H. Arch, Keyur Patel, Detlef Schuppan Published in: American Journal of Physiology-Gastrointestinal and Liver Physiology, Issue 316/1, 2019, Page(s) G25-G31, ISSN 0193-1857 Publisher: American Physiological Society DOI: 10.1152/ajpgi.00158.2018 From NASH to HCC: current concepts and future challenges Author(s): Quentin M. Anstee, Helen L. Reeves, Elena Kotsiliti, Olivier Govaere, Mathias Heikenwalder Published in: Nature Reviews Gastroenterology & Hepatology, Issue 16/7, 2019, Page(s) 411-428, ISSN 1759-5045 Publisher: Nature Publishing Group DOI: 10.1038/s41575-019-0145-7 Mouse Models of Nonalcoholic Steatohepatitis: Toward Optimization of Their Relevance to Human Nonalcoholic Steatohepatitis Author(s): Geoff Farrell, Jörn M. Schattenberg, Isabelle Leclercq, Matthew M. Yeh, Robert Goldin, Narci Teoh, Detlef Schuppan Published in: Hepatology, Issue 69/5, 2019, Page(s) 2241-2257, ISSN 0270-9139 Publisher: John Wiley & Sons Inc. DOI: 10.1002/hep.30333 Phosphatidylglycerols are induced by gut dysbiosis and inflammation, and favorably modulate adipose tissue remodeling in obesity Author(s): Brandon D. Kayser, Marie Lhomme, Edi Prifti, Carla Da Cunha, Florian Marquet, Florian Chain, Isabelle Naas, Véronique Pelloux, Maria-Carlota Dao, Anatol Kontush, Salwa W. Rizkalla, Judith Aron-Wisnewsky, Luis G. Bermúdez-Humarán, Fiona Oakley, Philippe Langella, Karine Clément, Isabelle Dugail Published in: The FASEB Journal, Issue 33/4, 2019, Page(s) 4741-4754, ISSN 0892-6638 Publisher: Federation of American Societies for Experimental Biology DOI: 10.1096/fj.201801897r Improvement of non-invasive markers of NAFLD from an individualised, web-based exercise program Author(s): Yvonne Huber, Daniel Pfirrmann, Ines Gebhardt, Christian Labenz, Nadine Gehrke, Beate K. Straub, Christian Ruckes, Heike Bantel, Eugenio Belda, Karine Clément, Diana J. Leeming, Morten A. Karsdal, Peter R. Galle, Perikles Simon, Jörn M. Schattenberg Published in: Alimentary Pharmacology & Therapeutics, Issue 50/8, 2019, Page(s) 930-939, ISSN 0269-2813 Publisher: Blackwell Publishing Inc. DOI: 10.1111/apt.15427 qFIBS: A Novel Automated Technique for Quantitative Evaluation of Fibrosis, Inflammation, Ballooning, and Steatosis in Patients With Nonalcoholic Steatohepatitis Author(s): Feng Liu, George Boon‐Bee Goh, Dina Tiniakos, Aileen Wee, Wei‐Qiang Leow, Jing‐Min Zhao, Hui‐Ying Rao, Xiao‐Xiao Wang, Qin Wang, Wei‐Keat Wan, Kiat‐Hon Lim, Manuel Romero‐Gomez, Salvatore Petta, Elisabetta Bugianesi, Chee‐Kiat Tan, Stephen A. Harrison, Quentin M. Anstee, Pik‐Eu Jason Chang, Lai Wei Published in: Hepatology, 2019, ISSN 0270-9139 Publisher: John Wiley & Sons Inc. DOI: 10.1002/hep.30986 Lipidomes in health and disease: Analytical strategies and considerations Author(s): Fang Wei, Santosh Lamichhane, Matej Orešič, Tuulia Hyötyläinen Published in: TrAC Trends in Analytical Chemistry, Issue 120, 2019, Page(s) 115664, ISSN 0165-9936 Publisher: Elsevier BV DOI: 10.1016/j.trac.2019.115664 Performance of the PRO-C3 collagen neo-epitope biomarker in non-alcoholic fatty liver disease Author(s): Marie Boyle, Dina Tiniakos, Jorn M. Schattenberg, Vlad Ratziu, Elisabetta Bugianessi, Salvatore Petta, Claudia P. Oliveira, Olivier Govaere, Ramy Younes, Stuart McPherson, Pierre Bedossa, Mette J Nielsen, Morten Karsdal, Diana Leeming, Stuart Kendrick, Quentin M. Anstee Published in: JHEP Reports, Issue 1/3, 2019, Page(s) 188-198, ISSN 2589-5559 Publisher: Elsevier B.V. DOI: 10.1016/j.jhepr.2019.06.004 Voluntary exercise in mice fed an obesogenic diet alters the hepatic immune phenotype and improves metabolic parameters – an animal model of life style intervention in NAFLD Author(s): Nadine Gehrke, Jana Biedenbach, Yvonne Huber, Beate K. Straub, Peter R. Galle, Perikles Simon, Jörn M. Schattenberg Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-018-38321-9 Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites Author(s): You Zhou, Matej Orešič, Marja Leivonen, Peddinti Gopalacharyulu, Jenni Hyysalo, Johanna Arola, An Verrijken, Sven Francque, Luc Van Gaal, Tuulia Hyötyläinen, Hannele Yki-Järvinen Published in: Clinical Gastroenterology and Hepatology, Issue 14/10, 2016, Page(s) 1463-1472.e6, ISSN 1542-3565 Publisher: W. B. Saunders Co., Ltd. DOI: 10.1016/j.cgh.2016.05.046 Heterogeneity of non-alcoholic fatty liver disease Author(s): Hannele Yki-Järvinen, Panu K. Luukkonen Published in: Liver International, Issue 35/12, 2015, Page(s) 2498-2500, ISSN 1478-3223 Publisher: Blackwell Publishing Inc. DOI: 10.1111/liv.12970 Metabolic syndrome and severity of fibrosis in nonalcoholic fatty liver disease: An age-dependent risk profiling study Author(s): Salvatore Petta, Mohammed Eslam, Luca Valenti, Elisabetta Bugianesi, Marco Barbara, Calogero Cammà, Marianna Porzio, Chiara Rosso, Silvia Fargion, Jacob George, Antonio Craxì Published in: Liver International, Issue 37/9, 2017, Page(s) 1389-1396, ISSN 1478-3223 Publisher: Blackwell Publishing Inc. DOI: 10.1111/liv.13397 Non-pharmacological interventions in non-alcoholic fatty liver disease patients Author(s): Vlad Ratziu Published in: Liver International, Issue 37, 2017, Page(s) 90-96, ISSN 1478-3223 Publisher: Blackwell Publishing Inc. DOI: 10.1111/liv.13311 The impact of human activities and lifestyles on the interlinked microbiota and health of humans and of ecosystems Author(s): Lucette Flandroy, Theofilos Poutahidis, Gabriele Berg, Gerard Clarke, Maria-Carlota Dao, Ellen Decaestecker, Eeva Furman, Tari Haahtela, Sébastien Massart, Hubert Plovier, Yolanda Sanz, Graham Rook Published in: Science of The Total Environment, Issue 627, 2018, Page(s) 1018-1038, ISSN 0048-9697 Publisher: Elsevier BV DOI: 10.1016/j.scitotenv.2018.01.288 Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants Author(s): Gemma F. Codner, Joffrey Mianné, Adam Caulder, Jorik Loeffler, Rachel Fell, Ruairidh King, Alasdair J. Allan, Matthew Mackenzie, Fran J. Pike, Christopher V. McCabe, Skevoulla Christou, Sam Joynson, Marie Hutchison, Michelle E. Stewart, Saumya Kumar, Michelle M. Simon, Loranne Agius, Quentin M. Anstee, Kirill E. Volynski, Dimitri M. Kullmann, Sara Wells, Lydia Teboul Published in: BMC Biology, Issue 16/1, 2018, ISSN 1741-7007 Publisher: BioMed Central DOI: 10.1186/s12915-018-0530-7 NASH in Lean Individuals Author(s): Ramy Younes, Elisabetta Bugianesi Published in: Seminars in Liver Disease, Issue 39/01, 2019, Page(s) 086-095, ISSN 0272-8087 Publisher: Thieme Medical Publishers DOI: 10.1055/s-0038-1677517 Metabolic Modeling of Human Gut Microbiota on a Genome Scale: An Overview Author(s): Partho Sen, Matej Orešič Published in: Metabolites, Issue 9/2, 2019, Page(s) 22, ISSN 2218-1989 Publisher: MDPI DOI: 10.3390/metabo9020022 From NASH to diabetes and from diabetes to NASH: Mechanisms and treatment options Author(s): Amalia Gastaldelli, Kenneth Cusi Published in: JHEP Reports, Issue 1/4, 2019, Page(s) 312-328, ISSN 2589-5559 Publisher: Elsevier DOI: 10.1016/j.jhepr.2019.07.002 Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis Author(s): Olivier Govaere, Simon Cockell, Dina Tiniakos, Rachel Queen, Ramy Younes, Michele Vacca, Leigh Alexander, Federico Ravaioli, Jeremy Palmer, Salvatore Petta, Jerome Boursier, Chiara Rosso, Katherine Johnson, Kristy Wonders, Christopher P. Day, Mattias Ekstedt, Matej Orešič, Rebecca Darlay, Heather J. Cordell, Fabio Marra, Antonio Vidal-Puig, Pierre Bedossa, Jörn M. Schattenberg, Karine Clément, Published in: Science Translational Medicine, Issue 12/572, 2020, Page(s) eaba4448, ISSN 1946-6234 Publisher: American Association for the Advancement of Science DOI: 10.1126/scitranslmed.aba4448 Non-peer reviewed articles (2) Editorial: hepatocellular carcinoma in non-cirrhotic NASH-a troubling reality Author(s): Marie Boyle, Quentin M. Anstee Published in: Alimentary Pharmacology & Therapeutics, Issue 48/9, 2018, Page(s) 1021-1023, ISSN 0269-2813 Publisher: Blackwell Publishing Inc. DOI: 10.1111/apt.14982 Editorial: collagen proportionate area as a prognostic indicator in NAFLD Author(s): Federico Ravaioli, Quentin M. Anstee Published in: Alimentary Pharmacology & Therapeutics, Issue 49/11, 2019, Page(s) 1452-1454, ISSN 0269-2813 Publisher: Blackwell Publishing Inc. DOI: 10.1111/apt.15249 Conference proceedings (7) Bile acids composition modulate insulin resistance in non-diabetic patients with NAFLD Author(s): Rosso, C.; Younes, R.; Eslam, M.; Chen, Fw.; Cucco, M.; Gaggini, M.; Coulter, S.; Carli, F.; Barbieri, C.; della Latta, V.; Abate, M. L.; Saracco, Gm.; Gastaldelli, A.; George, J.; Bugianesi, E. Published in: Issue 21, 2018 Publisher: Elsevier Inc. Predisposition to diabetes is related to insulin resistance in NAFLD patients and to decreased insulin secretion in HCV patients Author(s): Pierantonelli, G. Svegliati-Baroni I.; Younes, R.; Rosso, C.; Rychlicki, C.; Bugianesi, E.; Gastaldelli, A. Published in: Issue 5, 2018 Publisher: Elsevier Inc. In non obese NAFLD increased plasma saturated fatty acids and insulin resistance are metabolic signatures of severity of liver disease Author(s): Carli, F.; Gaggini, M.; Rosso, C.; Saponaro, C.; Barbieri, C.; Latta, V. D.; Buzzigoli, E.; Ciociaro, D.; Abate, M. L.; Marietti, M.; Younes, R.; Bugianesi, E.; Gastaldelli, A. Published in: Issue 8, 2018 Publisher: Elsevier Inc. Hepatic macrophage activation is associated with adipose tissue insulin resistance in non-diabetic patients with Non-Alcoholic Fatty Liver Disease Author(s): Rosso, Chiara; Kazankov, K.; Marietti, Milena; Gaggini, M.; Buzzigoli, E.; Møller, H. J.; Caviglia, GIAN PAOLO; Abate, Maria Lorena; Smedile, Antonina; Saracco, Giorgio Maria; Vilstrup, H.; Gastaldelli, A.; George, J.; Grønbæk, H.; Bugianesi, Elisabetta Published in: Issue 12, 2016 Publisher: John Wiley & Sons, Inc. Plasma Selenoprotein P levels are related to adipose tissue insulin resistance, composition of free fatty acids and liver fibrosis in non-diabetic patients with Non Alcoholic Fatty Liver Disease Author(s): Rosso, Chiara; Younes, Ramy; Fabrizia, Carli; Melania, Gaggini; Lavinia, Mezzabotta; Marietti, Milena; Federico, Salomone; Gambino, Roberto; Saba, Francesca; Emma, Buzzigoli; Demetrio, Ciociaro; Caviglia, GIAN PAOLO; Morello, Elisabetta; Abate, Maria Lorena; Smedile, Antonina; Ciancio, Alessia; Cassader, Maurizio; Saracco, Giorgio Maria; Amalia, Gastaldelli; Bugianesi, Elisabetta Published in: Issue 9, 2017 Publisher: John Wiey & Sons, Inc. Insulin secretion and decreased glucose clearance are associated with enhanced fibrogenesis and a high risk of disease progression in non-diabetic patients with Non Alcoholic Fatty Liver Disease Author(s): Younes, Ramy; Rosso, Chiara; Melania, Gaggini; Lavinia, Mezzabotta; Marietti, Milena; Fabrizia, Carli; Federico, Salomone; Emma, Buzzigoli; Caviglia, GIAN PAOLO; Chiara, Barbieri; Abate, Maria Lorena; Smedile, Antonina; Saracco, Giorgio Maria; Anstee, Quentin M.; Leeming, Diana J.; Amalia, Gastaldelli; Detlef, Schuppan; Bugianesi, Elisabetta Published in: Issue 9, 2017 Publisher: John Wiley & Sons, Inc. Hepatocellular carcinoma and metabolic risk factors in a main reference center in Italy Author(s): Younes, R; Rosso, C; Marietti, M; Caviglia, Gp; Nascè, A; Campion, D; Cantamessa, A; Carucci, P; Bugianesi, E Published in: Issue 9, 2017 Publisher: Elsevier Inc. Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
