Exploring the combined role of genetic and non-genetic factors for developing Age-Related Macular Degeneration: A systems level analysis of disease subgroups, risk factors, and pathways

Livrables

Establishment and launch of the EYE-RISK website; creation of a website with two levels of accessibility, one for the public and one restricted to project members; regular updates after launch of the website.

Dissemination

EYE-RISK leaflets or leporellos developed, designed and sent to beneficiaries for further distribution/dissemination.

Workshops

EYE-RISK workshops organised.

Publications

Geographic distribution of rare variants associated with age-related macular degeneration

Auteurs: Geerlings, Maartje J.; Kersten, Eveline; Groenewoud, Joannes M.M.; Fritsche, Lars G.; Hoyng, Carel B.; de Jong, Eiko K.; den Hollander, Anneke I.
Publié dans: Molecular Vision, Numéro 24, 2018, Page(s) 75-82, ISSN 1090-0535
Éditeur: Molecular Vision

A new perspective on lipid research in age-related macular degeneration

Auteurs: Elisabeth M. van Leeuwen, Eszter Emri, Benedicte M.J. Merle, Johanna M. Colijn, Eveline Kersten, Audrey Cougnard-Gregoire, Sascha Dammeier, Magda Meester-Smoor, Frances M. Pool, Eiko K. de Jong, Cécile Delcourt, Eduardo Rodrigez-Bocanegra, Marc Biarnés, Philip J. Luthert, Marius Ueffing, Caroline C.W. Klaver, Everson Nogoceke, Anneke I. den Hollander, Imre Lengyel
Publié dans: Progress in Retinal and Eye Research, 2018, ISSN 1350-9462
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.preteyeres.2018.04.006

Whole-Exome Sequencing in Age-Related Macular Degeneration Identifies Rare Variants in COL8A1 , a Component of Bruch’s Membrane

Auteurs: Jordi Corominas, Johanna M. Colijn, Maartje J. Geerlings, Marc Pauper, Bjorn Bakker, Najaf Amin, Laura Lores Motta, Eveline Kersten, Alejandro Garanto, Joost A.M. Verlouw, Jeroen G.J. van Rooij, Robert Kraaij, Paulus T.V.M. de Jong, Albert Hofman, Johannes R. Vingerling, Tina Schick, Sascha Fauser, Eiko K. de Jong, Cornelia M. van Duijn, Carel B. Hoyng, Caroline C.W. Klaver, Anneke I. den Hollande
Publié dans: Ophthalmology, 2018, ISSN 0161-6420
Éditeur: Elsevier BV
DOI: 10.1016/j.ophtha.2018.03.040

Phenotype Characteristics of Patients With Age-Related Macular Degeneration Carrying a Rare Variant in the Complement Factor H Gene

Auteurs: Eveline Kersten, Maartje J. Geerlings, Anneke I. den Hollander, Eiko K. de Jong, Sascha Fauser, Tunde Peto, Carel B. Hoyng
Publié dans: JAMA Ophthalmology, Numéro 135/10, 2017, Page(s) 1037, ISSN 2168-6165
Éditeur: American Medical Association
DOI: 10.1001/jamaophthalmol.2017.3195

Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration

Auteurs: Swati Arya, Eszter Emri, Silvia A. Synowsky, Sally L. Shirran, Neda Barzegar-Befroei, Tunde Peto, Catherine H. Botting, Imre Lengyel, Alan J. Stewart
Publié dans: Experimental Eye Research, Numéro 172, 2018, Page(s) 21-29, ISSN 0014-4835
Éditeur: Academic Press
DOI: 10.1016/j.exer.2018.03.023

The effects of zinc supplementation on primary human retinal pigment epithelium

Auteurs: Po-Jung Pao, Eszter Emri, Safiya Bishar Abdirahman, Talha Soorma, Hui-Hui Zeng, Stefanie M. Hauck, Richard B. Thompson, Imre Lengyel
Publié dans: Journal of Trace Elements in Medicine and Biology, 2018, ISSN 0946-672X
Éditeur: Elsevier BV
DOI: 10.1016/j.jtemb.2018.02.028

The unconventional secretion of ARMS2

Auteurs: Elod Kortvely, Stefanie M. Hauck, Jennifer Behler, Nurulain Ho, Marius Ueffing
Publié dans: Human Molecular Genetics, 2016, Page(s) ddw162, ISSN 0964-6906
Éditeur: Oxford University Press
DOI: 10.1093/hmg/ddw162

Opportunities and Challenges of Whole-Cell and -Tissue Simulations of the Outer Retina in Health and Disease

Auteurs: Philip J. Luthert, Luis Serrano, Christina Kiel
Publié dans: Annual Review of Biomedical Data Science, Numéro 1/1, 2018, Page(s) 131-152, ISSN 2574-3414
Éditeur: Annual Reviews
DOI: 10.1146/annurev-biodatasci-080917-013356

Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration

Auteurs: Bénédicte M.J. Merle, Johanna M. Colijn, Audrey Cougnard-Grégoire, Alexandra P.M. de Koning-Backus, Marie-Noëlle Delyfer, Jessica C. Kiefte-de Jong, Magda Meester-Smoor, Catherine Féart, Timo Verzijden, Cécilia Samieri, Oscar H. Franco, Jean-François Korobelnik, Caroline C.W. Klaver, Cécile Delcourt, Soufiane Ajana, Blanca Arango-Gonzalez, Angela Armento, Verena Arndt, Vaibhav Bhatia, Shom
Publié dans: Ophthalmology, Numéro 126/3, 2019, Page(s) 381-390, ISSN 0161-6420
Éditeur: Elsevier BV
DOI: 10.1016/j.ophtha.2018.08.006

Metabolomics in serum of patients with non-advanced age-related macular degeneration reveals aberrations in the glutamine pathway

Auteurs: Eveline Kersten, Sascha Dammeier, Soufiane Ajana, Joannes M. M. Groenewoud, Marius Codrea, Franziska Klose, Yara T. Lechanteur, Sascha Fauser, Marius Ueffing, Cécile Delcourt, Carel B. Hoyng, Eiko K. de Jong, Anneke I. den Hollander
Publié dans: PLOS ONE, Numéro 14/6, 2019, Page(s) e0218457, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0218457

Genetic risk score has added value over initial clinical grading stage in predicting disease progression in age-related macular degeneration

Auteurs: Thomas J. Heesterbeek, Eiko K. de Jong, Ilhan E. Acar, Joannes M. M. Groenewoud, Bart Liefers, Clara I. Sánchez, Tunde Peto, Carel B. Hoyng, Daniel Pauleikhoff, Hans W. Hense, Anneke I. den Hollander
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-43144-3

Genetic screening for macular dystrophies in patients clinically diagnosed with dry age‐related macular degeneration

Auteurs: Eveline Kersten, Maartje J. Geerlings, Marc Pauper, Jordi Corominas, Bjorn Bakker, Lebriz Altay, Sascha Fauser, Eiko K. de Jong, Carel B. Hoyng, Anneke I. den Hollander
Publié dans: Clinical Genetics, Numéro 94/6, 2018, Page(s) 569-574, ISSN 0009-9163
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/cge.13447

The Rate of Progression of Geographic Atrophy Decreases With Increasing Baseline Lesion Size Even After the Square Root Transformation

Auteurs: Jordi Monés, Marc Biarnés
Publié dans: Translational Vision Science & Technology, Numéro 7/6, 2018, Page(s) 40, ISSN 2164-2591
Éditeur: Association for Research in Vision and Ophthalmology Inc.
DOI: 10.1167/tvst.7.6.40

Drusen Ooze: A Novel Hypothesis in Geographic Atrophy

Auteurs: Jordi Monés, Míriam Garcia, Marc Biarnés, Aparna Lakkaraju, Lucia Ferraro
Publié dans: Ophthalmology Retina, 2017, ISSN 2468-6530
Éditeur: Elsevier
DOI: 10.1016/j.oret.2017.02.006

Subretinal Pigment Epithelial Deposition of Drusen Components Including Hydroxyapatite in a Primary Cell Culture Model

Auteurs: Matthew G. Pilgrim, Imre Lengyel, Antonio Lanzirotti, Matt Newville, Sarah Fearn, Eszter Emri, Jonathan C. Knowles, Jeffrey D. Messinger, Russell W. Read, Clyde Guidry, Christine A. Curcio
Publié dans: Investigative Opthalmology & Visual Science, Numéro 58/2, 2017, Page(s) 708, ISSN 1552-5783
Éditeur: Cadmus
DOI: 10.1167/iovs.16-21060

Simple and complex retinal dystrophies are associated with profoundly different disease networks

Auteurs: Christina Kiel, Claire Lastrucci, Philip J. Luthert, Luis Serrano
Publié dans: Scientific Reports, Numéro 7, 2017, Page(s) 41835, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/srep41835

Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration

Auteurs: Eveline Kersten, Constantin C. Paun, Rosa L. Schellevis, Carel. B. Hoyng, Cécile Delcourt, Imre Lengyel, Tunde Peto, Marius Ueffing, Caroline C.W. Klaver, Sascha Dammeier, Anneke I. den Hollander, Eiko K. de Jong
Publié dans: Survey of Ophthalmology, 2017, ISSN 0039-6257
Éditeur: Elsevier BV
DOI: 10.1016/j.survophthal.2017.05.003

Prevalence of Age-Related Macular Degeneration in Europe

Auteurs: Johanna M. Colijn, Gabriëlle H.S. Buitendijk, Elena Prokofyeva, Dalila Alves, Maria L. Cachulo, Anthony P. Khawaja, Audrey Cougnard-Gregoire, Bénédicte M.J. Merle, Christina Korb, Maja G. Erke, Alain Bron, Eleftherios Anastasopoulos, Magda A. Meester-Smoor, Tatiana Segato, Stefano Piermarocchi, Paulus T.V.M. de Jong, Johannes R. Vingerling, Fotis Topouzis, Catherine Creuzot-Garcher, Geir Bertel
Publié dans: Ophthalmology, 2017, ISSN 0161-6420
Éditeur: Elsevier BV
DOI: 10.1016/j.ophtha.2017.05.035

Geographic atrophy phenotype identification by cluster analysis

Auteurs: Jordi Monés, Marc Biarnés
Publié dans: British Journal of Ophthalmology, 2017, Page(s) bjophthalmol-2017-310268, ISSN 0007-1161
Éditeur: BMJ Publishing Group
DOI: 10.1136/bjophthalmol-2017-310268

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