Exploring the combined role of genetic and non-genetic factors for developing Age-Related Macular Degeneration: A systems level analysis of disease subgroups, risk factors, and pathways

Rezultaty

Establishment and launch of the EYE-RISK website; creation of a website with two levels of accessibility, one for the public and one restricted to project members; regular updates after launch of the website.

Dissemination

EYE-RISK leaflets or leporellos developed, designed and sent to beneficiaries for further distribution/dissemination.

Workshops

EYE-RISK workshops organised.

Publikacje

Geographic distribution of rare variants associated with age-related macular degeneration

Autorzy: Geerlings, Maartje J.; Kersten, Eveline; Groenewoud, Joannes M.M.; Fritsche, Lars G.; Hoyng, Carel B.; de Jong, Eiko K.; den Hollander, Anneke I.
Opublikowane w: Molecular Vision, Numer 24, 2018, Strona(/y) 75-82, ISSN 1090-0535
Wydawca: Molecular Vision

A new perspective on lipid research in age-related macular degeneration

Autorzy: Elisabeth M. van Leeuwen, Eszter Emri, Benedicte M.J. Merle, Johanna M. Colijn, Eveline Kersten, Audrey Cougnard-Gregoire, Sascha Dammeier, Magda Meester-Smoor, Frances M. Pool, Eiko K. de Jong, Cécile Delcourt, Eduardo Rodrigez-Bocanegra, Marc Biarnés, Philip J. Luthert, Marius Ueffing, Caroline C.W. Klaver, Everson Nogoceke, Anneke I. den Hollander, Imre Lengyel
Opublikowane w: Progress in Retinal and Eye Research, 2018, ISSN 1350-9462
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.preteyeres.2018.04.006

Whole-Exome Sequencing in Age-Related Macular Degeneration Identifies Rare Variants in COL8A1 , a Component of Bruch’s Membrane

Autorzy: Jordi Corominas, Johanna M. Colijn, Maartje J. Geerlings, Marc Pauper, Bjorn Bakker, Najaf Amin, Laura Lores Motta, Eveline Kersten, Alejandro Garanto, Joost A.M. Verlouw, Jeroen G.J. van Rooij, Robert Kraaij, Paulus T.V.M. de Jong, Albert Hofman, Johannes R. Vingerling, Tina Schick, Sascha Fauser, Eiko K. de Jong, Cornelia M. van Duijn, Carel B. Hoyng, Caroline C.W. Klaver, Anneke I. den Hollande
Opublikowane w: Ophthalmology, 2018, ISSN 0161-6420
Wydawca: Elsevier BV
DOI: 10.1016/j.ophtha.2018.03.040

Phenotype Characteristics of Patients With Age-Related Macular Degeneration Carrying a Rare Variant in the Complement Factor H Gene

Autorzy: Eveline Kersten, Maartje J. Geerlings, Anneke I. den Hollander, Eiko K. de Jong, Sascha Fauser, Tunde Peto, Carel B. Hoyng
Opublikowane w: JAMA Ophthalmology, Numer 135/10, 2017, Strona(/y) 1037, ISSN 2168-6165
Wydawca: American Medical Association
DOI: 10.1001/jamaophthalmol.2017.3195

Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration

Autorzy: Swati Arya, Eszter Emri, Silvia A. Synowsky, Sally L. Shirran, Neda Barzegar-Befroei, Tunde Peto, Catherine H. Botting, Imre Lengyel, Alan J. Stewart
Opublikowane w: Experimental Eye Research, Numer 172, 2018, Strona(/y) 21-29, ISSN 0014-4835
Wydawca: Academic Press
DOI: 10.1016/j.exer.2018.03.023

The effects of zinc supplementation on primary human retinal pigment epithelium

Autorzy: Po-Jung Pao, Eszter Emri, Safiya Bishar Abdirahman, Talha Soorma, Hui-Hui Zeng, Stefanie M. Hauck, Richard B. Thompson, Imre Lengyel
Opublikowane w: Journal of Trace Elements in Medicine and Biology, 2018, ISSN 0946-672X
Wydawca: Elsevier BV
DOI: 10.1016/j.jtemb.2018.02.028

The unconventional secretion of ARMS2

Autorzy: Elod Kortvely, Stefanie M. Hauck, Jennifer Behler, Nurulain Ho, Marius Ueffing
Opublikowane w: Human Molecular Genetics, 2016, Strona(/y) ddw162, ISSN 0964-6906
Wydawca: Oxford University Press
DOI: 10.1093/hmg/ddw162

Opportunities and Challenges of Whole-Cell and -Tissue Simulations of the Outer Retina in Health and Disease

Autorzy: Philip J. Luthert, Luis Serrano, Christina Kiel
Opublikowane w: Annual Review of Biomedical Data Science, Numer 1/1, 2018, Strona(/y) 131-152, ISSN 2574-3414
Wydawca: Annual Reviews
DOI: 10.1146/annurev-biodatasci-080917-013356

Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration

Autorzy: Bénédicte M.J. Merle, Johanna M. Colijn, Audrey Cougnard-Grégoire, Alexandra P.M. de Koning-Backus, Marie-Noëlle Delyfer, Jessica C. Kiefte-de Jong, Magda Meester-Smoor, Catherine Féart, Timo Verzijden, Cécilia Samieri, Oscar H. Franco, Jean-François Korobelnik, Caroline C.W. Klaver, Cécile Delcourt, Soufiane Ajana, Blanca Arango-Gonzalez, Angela Armento, Verena Arndt, Vaibhav Bhatia, Shom
Opublikowane w: Ophthalmology, Numer 126/3, 2019, Strona(/y) 381-390, ISSN 0161-6420
Wydawca: Elsevier BV
DOI: 10.1016/j.ophtha.2018.08.006

Metabolomics in serum of patients with non-advanced age-related macular degeneration reveals aberrations in the glutamine pathway

Autorzy: Eveline Kersten, Sascha Dammeier, Soufiane Ajana, Joannes M. M. Groenewoud, Marius Codrea, Franziska Klose, Yara T. Lechanteur, Sascha Fauser, Marius Ueffing, Cécile Delcourt, Carel B. Hoyng, Eiko K. de Jong, Anneke I. den Hollander
Opublikowane w: PLOS ONE, Numer 14/6, 2019, Strona(/y) e0218457, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0218457

Genetic risk score has added value over initial clinical grading stage in predicting disease progression in age-related macular degeneration

Autorzy: Thomas J. Heesterbeek, Eiko K. de Jong, Ilhan E. Acar, Joannes M. M. Groenewoud, Bart Liefers, Clara I. Sánchez, Tunde Peto, Carel B. Hoyng, Daniel Pauleikhoff, Hans W. Hense, Anneke I. den Hollander
Opublikowane w: Scientific Reports, Numer 9/1, 2019, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-019-43144-3

Genetic screening for macular dystrophies in patients clinically diagnosed with dry age‐related macular degeneration

Autorzy: Eveline Kersten, Maartje J. Geerlings, Marc Pauper, Jordi Corominas, Bjorn Bakker, Lebriz Altay, Sascha Fauser, Eiko K. de Jong, Carel B. Hoyng, Anneke I. den Hollander
Opublikowane w: Clinical Genetics, Numer 94/6, 2018, Strona(/y) 569-574, ISSN 0009-9163
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/cge.13447

The Rate of Progression of Geographic Atrophy Decreases With Increasing Baseline Lesion Size Even After the Square Root Transformation

Autorzy: Jordi Monés, Marc Biarnés
Opublikowane w: Translational Vision Science & Technology, Numer 7/6, 2018, Strona(/y) 40, ISSN 2164-2591
Wydawca: Association for Research in Vision and Ophthalmology Inc.
DOI: 10.1167/tvst.7.6.40

Drusen Ooze: A Novel Hypothesis in Geographic Atrophy

Autorzy: Jordi Monés, Míriam Garcia, Marc Biarnés, Aparna Lakkaraju, Lucia Ferraro
Opublikowane w: Ophthalmology Retina, 2017, ISSN 2468-6530
Wydawca: Elsevier
DOI: 10.1016/j.oret.2017.02.006

Subretinal Pigment Epithelial Deposition of Drusen Components Including Hydroxyapatite in a Primary Cell Culture Model

Autorzy: Matthew G. Pilgrim, Imre Lengyel, Antonio Lanzirotti, Matt Newville, Sarah Fearn, Eszter Emri, Jonathan C. Knowles, Jeffrey D. Messinger, Russell W. Read, Clyde Guidry, Christine A. Curcio
Opublikowane w: Investigative Opthalmology & Visual Science, Numer 58/2, 2017, Strona(/y) 708, ISSN 1552-5783
Wydawca: Cadmus
DOI: 10.1167/iovs.16-21060

Simple and complex retinal dystrophies are associated with profoundly different disease networks

Autorzy: Christina Kiel, Claire Lastrucci, Philip J. Luthert, Luis Serrano
Opublikowane w: Scientific Reports, Numer 7, 2017, Strona(/y) 41835, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/srep41835

Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration

Autorzy: Eveline Kersten, Constantin C. Paun, Rosa L. Schellevis, Carel. B. Hoyng, Cécile Delcourt, Imre Lengyel, Tunde Peto, Marius Ueffing, Caroline C.W. Klaver, Sascha Dammeier, Anneke I. den Hollander, Eiko K. de Jong
Opublikowane w: Survey of Ophthalmology, 2017, ISSN 0039-6257
Wydawca: Elsevier BV
DOI: 10.1016/j.survophthal.2017.05.003

Prevalence of Age-Related Macular Degeneration in Europe

Autorzy: Johanna M. Colijn, Gabriëlle H.S. Buitendijk, Elena Prokofyeva, Dalila Alves, Maria L. Cachulo, Anthony P. Khawaja, Audrey Cougnard-Gregoire, Bénédicte M.J. Merle, Christina Korb, Maja G. Erke, Alain Bron, Eleftherios Anastasopoulos, Magda A. Meester-Smoor, Tatiana Segato, Stefano Piermarocchi, Paulus T.V.M. de Jong, Johannes R. Vingerling, Fotis Topouzis, Catherine Creuzot-Garcher, Geir Bertel
Opublikowane w: Ophthalmology, 2017, ISSN 0161-6420
Wydawca: Elsevier BV
DOI: 10.1016/j.ophtha.2017.05.035

Geographic atrophy phenotype identification by cluster analysis

Autorzy: Jordi Monés, Marc Biarnés
Opublikowane w: British Journal of Ophthalmology, 2017, Strona(/y) bjophthalmol-2017-310268, ISSN 0007-1161
Wydawca: BMJ Publishing Group
DOI: 10.1136/bjophthalmol-2017-310268

Rezultaty

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