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Novel marine biomolecules against biofilm. Application to medical devices.

Objective

Microalgae are a source of secondary metabolites useful as new bioactive compounds. Activity of these compounds against bacterial pathogens and biofilm formation has not been determined yet. Biofilm formation is especially important in infections and tissue inflammation related to implants and catheters. These problems finally cause a release of the implant, which must be removed and replaced by a new one, entailing an increase in antibiotic consumption, together with a health costs of about 50,000-90,000 € per infection episode.
Taking both problems in account, the search of new antimicrobial agents that will be effective against the bacteria in their two ways of life, planktonic and biofilm stage, is a priority need in the clinical practice.
For this reason, the overall objective of NOMORFILM project is to search for antibiofilm compounds isolated from microalgae that will be useful in the treatment of this kind of infections and could be incorporated in the manufacturing of medical prosthetic devices. For this purpose, 4,000 microalgae species will be deeply screened specifically for new antibacterial and antibiofilm molecules. Structural elucidation of bioactive compounds from these extracts will assure that only new chemical entities, therefore with anticipated new mechanisms of action, will arise to further project stages, those including toxicity tests and animal models.
This project also addresses the biosynthesis of the targeted bioactive compounds in sustainable microalgae co-cultures, diminishing cultivation costs by mimicking natural aquatic ecosystems.
Most industrially interesting antibiofilm molecules will be incorporated into nanoparticles in order to develop manufacturing methodologies able to incorporate these compounds into real prosthetic devices matrixes. Marketing of results are assured by the presence of diverse SMEs along the manufacture and distribution of prosthetic devices, and the corresponding consortium agreements with respect to IPRs

Call for proposal

H2020-BG-2014-2
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Coordinator

FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA
Address
C Rossello 132 Planta 05
08036 Barcelona

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Activity type
Research Organisations
EU contribution
€ 997 085,03

Participants (14)

UNIVERSIDADE DE COIMBRA
EU contribution
€ 505 821
Address
Paco Das Escolas
3004-531 Coimbra

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Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD DE OVIEDO
EU contribution
€ 575 288
Address
Calle San Francisco 3
33003 Oviedo

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Activity type
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
EU contribution
€ 475 000
Address
Nobels Vag 5
17177 Stockholm

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Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI FIRENZE
EU contribution
€ 645 975
Address
Piazza San Marco 4
50121 Florence

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Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD DE ALMERIA
EU contribution
€ 358 031
Address
Carretera Sacramento Canada
04120 Almeria

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Activity type
Higher or Secondary Education Establishments
KOBENHAVNS UNIVERSITET
EU contribution
€ 622 285
Address
Norregade 10
1165 Kobenhavn

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Activity type
Higher or Secondary Education Establishments
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
EU contribution
€ 358 759
Address
College Green Trinity College
D02 CX56 Dublin 2

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Activity type
Higher or Secondary Education Establishments
Fotosintetica & Microbiologica S.r.l.
EU contribution
€ 458 075
Address
Via Dei Della Robbia 54
50132 Firenze

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NANOMEDPHARMA LTD

Participation ended

EU contribution
€ 246 770,97
Address
Hope Business Gateway Eden Building Hope Park
L16 9JD Liverpool

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KTEDOGEN SRL
EU contribution
€ 633 925
Address
Via Monte Morone Snc
21046 Malnate

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MBA INCORPORADO SL
EU contribution
€ 295 000
Address
Avda Jardin Botanico 1345 Edificio Silos Del Intra
33203 Gijon

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PYROGENESIS SA
EU contribution
€ 729 625
Address
Athens-lavrion Ave, Technological Park 1
19500 Lavrion

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CENTRO INTERDISCIPLINAR DE INVESTIGACAO MARINHA E AMBIENTAL
EU contribution
€ 337 300
Address
Av General Norton De Matos S/n
4450 208 Matosinhos

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Activity type
Research Organisations
SORBONNE UNIVERSITE
EU contribution
€ 412 375
Address
21 Rue De L'ecole De Medecine
75006 Paris

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Activity type
Higher or Secondary Education Establishments